[PDF] Top 20 Genetic association analysis for common variants in the Genetic Analysis Workshop 18 data: a Dirichlet regression approach
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Genetic association analysis for common variants in the Genetic Analysis Workshop 18 data: a Dirichlet regression approach
... Genetic association analyses have had tremendous suc- cesses in recent years; however, most of these analyses were based on binary or continuous responses. Thus we propose a multivariate response vector ... See full document
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Rare variant analysis of blood pressure phenotypes in the Genetic Analysis Workshop 18 whole genome sequencing data using sequence kernel association test
... and common variants when collapsing them in a genomic ...the Genetic Analysis Workshop 18 data, we investigated whether performance of SKAT also depends on the weighting ... See full document
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Addition of multiple rare SNPs to known common variants improves the association between disease and gene in the Genetic Analysis Workshop 17 data
... real data, investigators will not be able to use the replications to calculate ...each common variant in each gene from a logistic regression model; (2) shuffle the common SNPs across the ... See full document
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Pathway based joint effects analysis of rare genetic variants using Genetic Analysis Workshop 17 exon sequence data
... This data- base includes 888 gene sets collected from 186 pathways from the Kyoto Encyclopedia of Genes and Genomes (KEGG) ...our data set, which left 472 pathways for fol- low-up ...three data- ... See full document
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Comparison of multilevel modeling and the family based association test for identifying genetic variants associated with systolic and diastolic blood pressure using Genetic Analysis Workshop 18 simulated data
... empirical data exhibit a hierarchical ...family-based genetic association studies ...model analysis in family-based genetic association studies, especially for longitudinal ... See full document
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Evaluation of gene based association tests for analyzing rare variants using Genetic Analysis Workshop 18 data
... gene-based approach using three strategies to group/bin the variants within each ...grouped variants that belong to the same gene and are of the same annotation type, that is, (a) coding ... See full document
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A LASSO penalized regression approach for genome wide association analyses using related individuals: application to the Genetic Analysis Workshop 19 simulated data
... new association method that combines LMM and LASSO to capitalize on the bene- fits of both ...(potential) common genetic back- ground among individuals through the use of a random polygenic ...family ... See full document
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Identifying rare variants using a Bayesian regression approach
... sequence data with rare variants in a cost-effective ...test variants individually are underpowered to detect rare variants, so it is desirable to perform association analysis of ... See full document
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Digging into the extremes: a useful approach for the analysis of rare variants with continuous traits?
... The common disease/rare variant hypothesis predicts that rare variants with large effects will have a strong impact on corresponding ...functional variants are enriched in the extremes of the ... See full document
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Enrichment analysis of genetic association in genes and pathways by aggregating signals from both rare and common variants
... genomic variants in genome-wide association studies of complex ...rare variants with appreciable effect sizes at the population level, existing methods mostly aggregate effects of multiple markers by ... See full document
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Collapsing ROC approach for risk prediction research on both common and rare variants
... emerging genetic findings holds great promise for improving public health and clinical ...existing common genetic loci, including those from genome-wide association studies, have lacked ... See full document
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Higher criticism approach to detect rare variants using whole genome sequencing data
... (WGS) data, the association test for variant groups is a key approach for genetic ...weak genetic effects to be detected, the higher criticism (HC) approach has been proposed and ... See full document
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Testing optimally weighted combination of variants for hypertension
... rare variants directly is possible with next-generation sequencing ...optimal-weighted approach to test for the effects of both rare and common variants across the whole ...the genetic ... See full document
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Analysis of Genetic Analysis Workshop 18 data with gene based penalized regression
... Genome-wide association studies have identified many common variants associated with complex diseases, yet these variants explain only a small proportion of the her- ...rare variants ... See full document
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Evaluation of logistic Bayesian LASSO for identifying association with rare haplotypes
... rare variants may hold the key to unraveling the genetic transmission mechanism of many common complex ...detect association with rare ...control data. By penalizing the ... See full document
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Challenges and directions: an analysis of Genetic Analysis Workshop 17 data by collapsing rare variants within family data
... risk variants. Two different methods — collapsing and family data — are suggested as alternatives for discovering these rare ...with common variants, rare variants have unique ...rare ... See full document
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Evaluation of association tests for rare variants using simulated data sets in the Genetic Analysis Workshop 17 data
... It is natural to ask why the average powers of these four methods are low for the analysis of the GAW17 data sets. There are three possible reasons. First, the phenotypes Q1 and Q2 do not completely depend ... See full document
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Entropy based method for assessing the influence of genetic markers and covariates on hypertension: application to Genetic Analysis Workshop 18 data
... the association between single-nucleotide polymorphisms (SNPs) and disease ...The association of genetics with outcome can be modified by covariates such as age, sex, smoking status, and membership to the ... See full document
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Using a Bayesian latent variable approach to detect pleiotropy in the Genetic Analysis Workshop 18 data
... for genetic stu- dies. For example, Ohara et al [10] proposed a LV approach for the analysis of multivariate quantitative trait loci; Tayo et al [11] applied a factor analysis (a subtype of ... See full document
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Pathway based analysis of rare and common variants to test for association with blood pressure
... genome-wide association study by Adeyemo et al [3] based on a population of African Americans (n = 1017) identified significant loci for SBP in or near the genes PMS1, SLC24A4, YWHA7, IPO7 , and CACANA1H , while ... See full document
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