[PDF] Top 20 Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... of latency is not yet ...LAT gene might prevent apoptosis in ...of virus production and immediate-early gene expression at the level of mRNA pro- duction ...the virus to replicate in ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... The assessment of cell cycle genes after transfection of LAT and cont-vect was carried out by Real-Time PCR. Based on the manufacture’s protocol 6.25µl of master mix SYBR ® Premix Ex Taq™ II (TAKARA), 0.8µM sense and ... See full document
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The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.
... In both experiments, the decreased spontaneous reactivation rate of the LAT deletion mutant compared with the parental or rescued virus was statistically significant McKrae versus dLAT29[r] ... See full document
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Regions of the Herpes Simplex Virus Type 1 Latency-Associated Transcript That Protect Cells from Apoptosis In Vitro and Protect Neuronal Cells In Vivo
... the latency-associated transcript (LAT) region of herpes simplex virus type 1 (HSV-1) is effective at blocking virus-induced apoptosis both in vitro ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... tion transcript termination signal inserted at various sites along the primary transcript, we present evidence that the epineph- rine-induced reactivation phenotype resides primarily within the 5 9 region ... See full document
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In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... The ribozyme used in this study targets the 5= exon region of the LAT primary transcript for cleavage. Cleaving the RNA in this region would be predicted to decrease levels of the primary LAT, spliced LAT, and the ... See full document
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Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... ICP0 transcript, an antisense mechanism of LAT function was also hypothesized (13, ...simian virus 40 RNA artificially ex- pressed in Xenopus laevis oocytes ... See full document
6
In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... during latency among all of the more than 70 HSV type 1 (HSV-1) ...-galactosidase gene as a ...both neuronal and nonneuronal ... See full document
7
The Latency-Associated Transcript Inhibits Apoptosis via Downregulation of Components of the Type I Interferon Pathway during Latent Herpes Simplex Virus 1 Ocular Infection
... (IE) gene expression-dependent downregulation of these factors during an acute infection ...the type I IFN pathway during ...limiting virus replication (55, 56), it is tempting to speculate that ... See full document
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Detection of herpes simplex virus type 1 latency-associated transcript expression in trigeminal ganglia by in situ reverse transcriptase PCR.
... of herpes simplex virus type 1 (HSV-1) infection is the ability of the virus to establish a lifelong latent state in ...HSV latency-associated tran- scripts ... See full document
5
Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1.
... By using various fragments and deletion constructs, this promoter activity 3269 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest To identify promoter regions which contr[r] ... See full document
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The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... Herpes simplex virus type 1 (HSV-1) is neurotropic virus capable of forming latent infections for the lifetime of an ...During latency, transcription is restricted ... See full document
10
Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... HSV latency is less ...antigen associated with major histocompatibility complex class I, thereby allowing infected cells to evade cell-mediated immu- nity ... See full document
7
The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency.
... during latency. Similarly, KOS-62, which has the lacZ gene inserted at the LAT locus, is not transcriptionally active during latency, as we had to delete the LTE from the PstI site to the HpaI in ... See full document
6
Expression of Herpes Simplex Virus 1-Encoded MicroRNAs in Human Trigeminal Ganglia and Their Relation to Local T-Cell Infiltrates
... Herpes simplex type 1 (HSV-1) is a neurotropic virus which establishes lifelong latency in human trigeminal ganglia ...HSV-1 latency are discussed: antiviral ... See full document
6
The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... this type of comparison, however, is that it requires comparing separate ChIP experiments for DRG from mice infected with two different virus ...histones associated with the LAT promoter, the 5 ⬘ ... See full document
11
Transcription of the Herpes Simplex Virus Latency-Associated Transcript Promotes the Formation of Facultative Heterochromatin on Lytic Promoters
... ICP8 gene promoters and the glyceraldehyde-3-phosphate dehydrogenase (GAPDH) gene (55), as well as LAT 5 ⬘ exon and mouse centromeres (26), have been described ...ICP27 gene promoter forward, ... See full document
9
The nucleotide sequence, 5' end, promoter domain, and kinetics of expression of the gene encoding the herpes simplex virus type 2 latency-associated transcript.
... The 5619 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The sequence of the herpes simplex virus type 2 HSV-2 latency-associated transcript LAT region resembles that o[r] ... See full document
5
A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... marker-rescued virus dLAT2903R, dLAT371 and its marker-rescued virus dLAT371R, and ...LAT transcript(s) made by each virus are detailed in ...LAT transcript in the wild- type and ... See full document
10
Structural and kinetic analyses of herpes simplex virus type 1 latency associated transcripts in human trigeminal ganglia and in cell culture
... demonstrate that in human trigeminal ganglia, the smaller (1.35 kb) HSV-1 transcript differs from the larger (1.85 kb) LAT by excision of an intron near its 5' end; they are otherwise colinear, and 5' ... See full document
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