[PDF] Top 20 Interaction with the Epstein-Barr Virus Helicase Targets Zta to DNA Replication Compartments
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Interaction with the Epstein-Barr Virus Helicase Targets Zta to DNA Replication Compartments
... the interaction domain for BBLF4-GFP using GST affinity ...that Zta binds to BBLF4 and that the aa 22 to 86 region of Zta was required for the ...construction, Zta(1–133) (Fig. 2B, upper ... See full document
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Pin1 Interacts with the Epstein-Barr Virus DNA Polymerase Catalytic Subunit and Regulates Viral DNA Replication
... cellular DNA replication ...viral replication, the EBV genome is amplified 100- to 1,000-fold by viral replication machinery composed of BALF5 DNA polymerase (Pol), BMRF1 polymerase ... See full document
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A Redox-Sensitive Cysteine in Zta Is Required for Epstein-Barr Virus Lytic Cycle DNA Replication
... compromise Zta-mediated cell cycle arrest (59). The bZIP domain of Zta is capable of rec- ognizing methylated DNA sequences with higher affinity than unmethylated DNA (10), and S186 ... See full document
12
Epstein-Barr Virus Protein Kinase BGLF4 Targets the Nucleus through Interaction with Nucleoporins
... pstein-Barr virus (EBV) is a ubiquitous gammaherpesvirus that infects most of the human population worldwide ...latent virus may be reacti- vated through expression of the viral immediate-early ... See full document
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Replication of Epstein-Barr virus oriLyt: lack of a dedicated virally encoded origin-binding protein and dependence on Zta in cotransfection assays.
... origin DNA and localized melting, and in addition T antigen, E1, and UL9 have intrinsic helicase activities that produce an initial unwinding of origin sequences prior to entrance of the remainder of the ... See full document
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Architecture of Replication Compartments Formed during Epstein-Barr Virus Lytic Replication
... Epstein-Barr virus (EBV) productive DNA replication occurs at discrete sites, called replication compart- ments, in ...the replication compartments during lytic ... See full document
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Identification of Acidic and Aromatic Residues in the Zta Activation Domain Essential for Epstein-Barr Virus Reactivation
... Epstein-Barr virus (EBV) lytic cycle transcription and DNA replication require the transcriptional activa- tion function of the viral immediate-early protein ...the Zta ... See full document
14
Epstein-Barr Virus Immediate-Early Protein Zta Co-Opts Mitochondrial Single-Stranded DNA Binding Protein To Promote Viral and Inhibit Mitochondrial DNA Replication
... infection. Epstein-Barr virus (EBV) lytic replication is initiated by the immediate-early protein ...Zta. Zta is a multifunctional DNA binding protein that stimulates ... See full document
9
Homologous Recombinational Repair Factors Are Recruited and Loaded onto the Viral DNA Genome in Epstein-Barr Virus Replication Compartments
... to DNA damage, RPA32 can be hyperphosphorylated by members of the phosphatidylinositol 3-kinase family, including DNA-dependent protein kinase, ATM, and ...to replication centers while having no ... See full document
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Different Distributions of Epstein-Barr Virus Early and Late Gene Transcripts within Viral Replication Compartments
... he Epstein-Barr virus (EBV), a human lymphotropic herpes- virus that infects more than 95% of the human adult popula- tion (1), is the causative agent of infectious mononucleosis and is also ... See full document
7
Critical Role of p53 in Histone Deacetylase Inhibitor-Induced Epstein-Barr Virus Zta Expression
... viral replication. For some DNA viruses, such as polyomaviruses and papillomaviruses, activation of p53 would lead to cell cycle arrest and thus impede viral replica- tion, because viral replication ... See full document
7
Uracil DNA Glycosylase BKRF3 Contributes to Epstein-Barr Virus DNA Replication through Physical Interactions with Proteins in Viral DNA Replication Complex
... that interaction of BKRF3 with other viral factors is required for BKRF3 nuclear tar- ...EBV DNA polymerase, ...the replication compartments ...viral DNA replication ma- ... See full document
17
Maribavir Inhibits Epstein-Barr Virus Transcription in Addition to Viral DNA Replication
... cellular targets including elongation factor 1 ␦ (24), condensin, topoisomerase II (33), replication origin-binding protein MCM4 (30), lamin A (34), histone protein H2AX (59), and interferon regulatory ... See full document
10
The Epstein-Barr Virus Lytic Transactivator Zta Interacts with the Helicase-Primase Replication Proteins
... for replication, while the enhancer ZREs are dispens- able ...oriLyt replication but has a significant effect on replication efficiency ...to Zta and Rta, oriLyt replication requires ... See full document
9
Functional Interaction between Epstein-Barr Virus Replication Protein Zta and Host DNA Damage Response Protein 53BP1
... of Zta, in vivo protein association assays were carried out in two cell systems containing EBV that were permissive to lytic re- ...of Zta, pCDNA3HisZta, to induce lytic cycle reactiva- ...isolate ... See full document
7
Identification of EBNA1 amino acid sequences required for the interaction of the functional elements of the Epstein-Barr virus latent origin of DNA replication.
... Unlike the interaction of bEBNA1 with onP, in which one element FR is bound prior to interaction Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest a bEBNAl proteins 1.4 pm[r] ... See full document
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Interaction of Epstein-Barr Virus BZLF1 C-Terminal Tail Structure and Core Zipper Is Required for DNA Replication but Not for Promoter Transactivation
... and DNA binding ...and DNA binding domains bound to DNA (8) confirmed this prediction and additionally revealed that BZLF1 residues in the C-terminal direction from Pro223 fold back against the ... See full document
5
Plasmid-like replicative intermediates of the Epstein-Barr virus lytic origin of DNA replication.
... oriLyt-mediated DNA replication, we analyzed newly replicated p526 DNA by Southern blot ...cellular DNA was extracted from D98HR1 cells cotransfected with pCMV-BZLF1 and the ...The DNA ... See full document
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Identification of cellular factors that bind specifically to the Epstein-Barr virus origin of DNA replication.
... To identify cellular proteins possibly involved in EBV plasmid maintenance, protein-DNA gel retardation experiments and DNase I footprinting were performed, * using HeLa cell nuclear ext[r] ... See full document
6
Effect of acyclovir [9-(2-hydroxyethoxymethyl)guanine] on Epstein-Barr virus DNA replication.
... Our studies were designed to determine the effects of ACV on EBV DNA replication in the virus-producing cell line P3HR-1, in the non- virus-producing line Raji, and in latently infected [r] ... See full document
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