[PDF] Top 20 The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
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The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... the virus (TRL, terminal repeat long; IRL, internal repeat long; IRS, internal repeat short; TRS, terminal repeat short) that bound the unique long (UL) and unique short (US) ...EGFP gene [including a 3⬘ ... See full document
7
Three Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutants with Distinct and Asymmetric Effects on Virulence in Mice Compared with Rabbits
... surviving rabbits harbor a bilateral latent HSV infection in both TG, resulting in a high group rate of spontaneous reactivation with the McKrae strain of ...reactivated virus was identical to the input ... See full document
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A Gene Capable of Blocking Apoptosis Can Substitute for the Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene and Restore Wild-Type Reactivation Levels
... LR gene of BHV-1 is clearly the homologue of the HSV-1 LAT gene, there are some important ...LAT transcript is 8.3 kb (45), whereas the primary LR transcript is only ...the ... See full document
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A Herpes Simplex Virus Type 1 Latency-Associated Transcript Mutant with Increased Virulence and Reduced Spontaneous Reactivation
... experiment 1 were greatly handicapped by the fact that only three of the ...Table 1), both of which contained more surviving rabbits in most ...in rabbits latently infected with ...from ... See full document
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Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... percentage of (-actin) mRNA was now detected in the nu- cleus (35% in uninfected cells to 55% in infected cells, as shown in Fig. 2). This decrease in cellular mRNA levels and the nuclear restriction of cellular mRNAs ... See full document
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Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latency.
... the establishment of latency (17), these experi- ments did not fully exclude a role for the LAT in the estab- lishment of latency because the mutation did not totally elim- inate acute LAT ... See full document
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Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... ate-early gene critical for reactivation from ...the virus in establishing latency. Once latency is estab- lished, LAP1 expresses LAT in order to maintain the latent state by inhibiting ICP0 ... See full document
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During Herpes Simplex Virus Type 1 Infection of Rabbits, the Ability To Express the Latency-Associated Transcript Increases Latent-Phase Transcription of Lytic Genes
... wild-type virus, the HSV-1 genome’s lytic gene promot- ers become associated with dimethyl histone H3 K9, a marker of transcriptional repression, during establishment of ... See full document
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Detection of herpes simplex virus type 1 latency-associated transcript expression in trigeminal ganglia by in situ reverse transcriptase PCR.
... with 1% HCl in PBS for 5 min, and then acetylated with acetic anhydride in triethanolamine for 20 ...then 1 3 SSC at room temperature, the digoxigenin-labeled probe was localized with an alkaline ... See full document
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Influence of Herpes Simplex Virus 1 Latency-Associated Transcripts on the Establishment and Maintenance of Latency in the ROSA26R Reporter Mouse Model
... possessed 1 to 10 or 10 to 100 HSV-1 genome copies at a range of inoculum ...lytic gene expression and replication in mouse neurons and neuronal cell lines (10, 22) and to encode microRNAs (miRNAs) ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... tion transcript termination signal inserted at various sites along the primary transcript, we present evidence that the epineph- rine-induced reactivation phenotype resides primarily within the 5 9 region ... See full document
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In vivo and in vitro reactivation impairment of a herpes simplex virus type 1 latency-associated transcript variant in a rabbit eye model.
... From studies of HSV-1 LAT+ and LAT- viruses in the rabbit model using both in vitro and in vivo reactivation techniques, the data support and extend previous conclusions that i LAT expre[r] ... See full document
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A deletion mutant of the latency-associated transcript of herpes simplex virus type 1 reactivates from the latent state with reduced frequency.
... American Society for Microbiology A Deletion Mutant of the Latency-Associated Transcript of Herpes Simplex Virus Type 1 Reactivates from the Latent State with Reduced Frequency Received [r] ... See full document
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Two open reading frames (ORF1 and ORF2) within the 2.0-kilobase latency-associated transcript of herpes simplex virus type 1 are not essential for reactivation from latency.
... None of the variants reported thus far contain a deletion that starts precisely at the 5' end of the 2.0-kb LAT or a deletion and/or insertion disrupting the putative ORF2 of 8071 Downlo[r] ... See full document
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The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... To verify this hypothesis, we demonstrated by RT-PCR and sequencing that these exons are spliced together and identified the splice donor and acceptor sites of the 2.0-kb LAT. Total RNA from COS-1 cells ... See full document
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Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... Transgenic mice are a useful tool to isolate the effects of individual viral proteins on viral pathogenesis in the initial absence of other viral functions (25). Two HSV transgenic mouse lines containing portions of the ... See full document
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Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... The latency-associated transcripts (LATs) of herpes simplex virus type 1 (HSV-1) are the only viral gene products that accumulate to abundant levels in ... See full document
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A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
... Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.. Expression of her[r] ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... HSV latency is less ...antigen associated with major histocompatibility complex class I, thereby allowing infected cells to evade cell-mediated immu- nity ... See full document
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Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1.
... By using various fragments and deletion constructs, this promoter activity 3269 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest To identify promoter regions which contr[r] ... See full document
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