[PDF] Top 20 Mutational analysis of the fingers domain of human immunodeficiency virus type 1 reverse transcriptase.
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Mutational analysis of the fingers domain of human immunodeficiency virus type 1 reverse transcriptase.
... The mutations are primarily single amino acid substitutions, but some involve 7533 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Using BspMI cassette vectors, we have [r] ... See full document
5
Cross-Linking of the Fingers Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase to Template-Primer
... the fingers domain of RT and DNA ...the fingers of p66 can interact with the extended template ...the fingers of p66 and the extended template involve the “open” configuration of the enzyme in ... See full document
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Mutations in Human Immunodeficiency Virus Type 1 Nucleocapsid Protein Zinc Fingers Cause Premature Reverse Transcription
... which reverse transcription can occur in extracellular virus ...cell type but are typically 3 to 5 M ...a domain of Gag-Pol) still has access to phys- iologically significant intracellular ... See full document
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Coding Sequences Upstream of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Domain in Gag-Pol Are Not Essential for Incorporation of the Pr160gag-pol into Virus Particles
... the human foamy virus pol gene is encoded as Pro-Pol, and the Pol prod- ucts can be incorporated into virus particles without the for- mation of a Gag-Pol ...into virus particles when MLV Pol ... See full document
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Comparison of Sequencing by Hybridization and Cycle Sequencing for Genotyping of Human Immunodeficiency Virus Type 1 Reverse Transcriptase
... Amino acid sequences were imported into Excel (version 7.0; Microsoft, Red- mond, Wash.). All differences between sequences determined by both meth- ods were noted. Additional analyses were performed with codons known to ... See full document
7
Influence of Reverse Transcriptase Variants, Drugs, and Vpr on Human Immunodeficiency Virus Type 1 Mutant Frequencies
... of human immunodeficiency virus type 1 (HIV-1) infection with the combination of three or more antiretroviral drugs has significantly reduced morbidity and mortality (22, ...two ... See full document
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Mutations in the Thumb Allow Human Immunodeficiency Virus Type 1 Reverse Transcriptase To Be Cleaved by Protease in Virions
... H domain, it is possible that these mutations could indirectly destabilize the ...the fingers subdomain, which when present to- ...Pol domain of ... See full document
9
Mutational Analysis of Residues in the Coiled-Coil Domain of Human Immunodeficiency Virus Type 1 Transmembrane Protein gp41
... vious mutational studies of the gp41 heptad repeat segment have shown that mutations in the “a” and “d” positions, par- ticularly helix-disrupting mutations, impair fusion activity (6, 10, 11, ... See full document
7
Human Immunodeficiency Virus Mutagenesis during Antiviral Therapy: Impact of Drug-Resistant Reverse Transcriptase and Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors on Human Immunodeficiency Virus Type 1 Mutation Frequencies
... Structural analysis. To help determine the underlying mo- lecular mechanisms by which drugs and drug resistance muta- tions alter the mutation frequency of HIV-1 subtype B and CRF01_A/E, we have conducted ... See full document
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Attenuated replication of human immunodeficiency virus type 1 with a didanosine-selected reverse transcriptase mutation.
... Lys70Arg virus replicated slightly more efficiently than WT virus in three independent assays of ...from 1 m g of cellular genomic DNA by PCR using primers described elsewhere (23, ...Sequence ... See full document
7
Construction and Characterization of a Temperature-Sensitive Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutant
... (ts) human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) mutant was generated by charged-cluster-to-alanine ...mutant virus, containing ... See full document
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Involvement of Novel Human Immunodeficiency Virus Type 1 Reverse Transcriptase Mutations in the Regulation of Resistance to Nucleoside Inhibitors
... in human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) whose role in drug resistance is still unknown by analyzing 1,906 plasma-derived ... See full document
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Human Immunodeficiency Virus Type 1 Subtype F Reverse Transcriptase Sequence and Drug Susceptibility
... Bootstrap analysis was performed with the SEQBOOT (100 resamplings), DNADIST, NEIGHBOR, and CONSENSE programs (PHYLIP ...Phylogenetic analysis was also performed by the maximum-likelihood method, using the ... See full document
5
Characterization and Structural Analysis of Novel Mutations in Human Immunodeficiency Virus Type 1 Reverse Transcriptase Involved in the Regulation of Resistance to Nonnucleoside Inhibitors
... MDS. Our computational work started with the analysis of the available crystallographic unbound models of RT. The 1DL0 PDB model (22) was judged as the most complete (971 residues; resolution ⫽ 2.70 Å) and was ... See full document
13
Effect of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Polymorphism Leu-214 on Replication Capacity and Drug Susceptibility
... pattern and a positive association with the TAM2 pattern have been observed (29). Moreover, it has recently been demon- strated the association of the Leu-214 with a favorable viro- logical response to thymidine ... See full document
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Mutational Analysis of the C-Terminal Gag Cleavage Sites in Human Immunodeficiency Virus Type 1
... late reverse transcription DNA products (plus-strand transfer; R-5⬘ untranslated region [UTR]) and 2-LTR junction products were carried out as previously described ...the virus stocks were used to assess ... See full document
8
Amino Acid Mutation N348I in the Connection Subdomain of Human Immunodeficiency Virus Type 1 Reverse Transcriptase Confers Multiclass Resistance to Nucleoside and Nonnucleoside Reverse Transcriptase Inhibitors
... of human immunodeficiency virus type 1 (HIV-1) infections in highly active antiretroviral therapies (HAART) can dramati- cally reduce viral load, increase levels of CD4positive ... See full document
10
Human Immunodeficiency Virus type 1 reverse transcriptase exists as post translationally modified forms in virions and cells
... electrophoresis analysis followed by silver stain or western blot, but these studies have not identified iso- forms of RT, possibly due to lower levels of RT or the use of isoelectric focussing strips of ... See full document
12
Sensitive Phenotypic Detection of Minor Drug Resistant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Variants
... and reverse transcription ...RT domain (200 to 500 ng) were cotransformed into DG1251 by using a lithium acetate protocol ...select reverse transcription events. Elements carrying wild-type RT ... See full document
9
Contributions of DNA polymerase subdomains to the RNase H activity of human immunodeficiency virus type 1 reverse transcriptase.
... 5721 Downloaded from http://jvi.asm.org/ on November 9, 2019 by guest Previous studies showed that an isolated human immunodeficiency virus type 1 HIV-1 RNase H domain expressed as a fus[r] ... See full document
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