[PDF] Top 20 Pleiotropic models of quantitative variation.

... HILL, 1989 Quantitative genetic variability maintained by mutation-selection balance: sampling variation and response to subsequent directional selection. KACSER, 1987 Dominance,[r] ... See full document

... was that phenotypic divergence was extremely gradual, consisting of many genes, each having an infinitesimally small effect on the trait (F isher 1930). This view of adap- tation had widespread support among early ... See full document

... In terms of quantitative genetic theory this means that the possi- ble pleiotropic effects of quantitative genetic variation are most often not changed by mutations at [r] ... See full document

... the genetic expression of two or more different traits, the alternative hypothesis. A Bayes factor approach to and genetic linkage, i.e., two genes affecting separate discriminate between nested models has been ... See full document

... variance is lower under loose linkage than under quantitative traits are unknown or can be inferred only very tight linkage, while the reverse is true if the indirectly. In addition, because the dimensionality of ... See full document

... If genetic variation is maintained by pleiotropic alleles in very low frequencies as in the house-of-cards model, then directional selection would tend to in- crease [r] ... See full document

... pure pleiotropic model (Keightley and Hill 1990; Kondrashov and Turelli 1992; Zhang et ...substantial quantitative genetic variation, but the apparent stabilizing selection of strength V s,t ⬎ V 2 G ... See full document

... With P element parameters, partitioning of the con- tribution to the genetic variance from different catego- ries of mutations (Table 2) shows that most of the vari- ance is co[r] ... See full document

... In a haploid population, the proportion of interaction variance is a function of the gene frequencies at the loci contributing to the flux variation, enzyme activities [r] ... See full document

... Because mutation does not change the mean of allelic effects and the increase of the genetic variance is expected to be constant, the model is also called t h e [r] ... See full document

... deviation from the mean, even for a trait that is purely Here we construct a pleiotropic model on the basis neutral and irrelevant to fitness (Gavrilets and de of previous theoretical studies and empirical data ... See full document

... Stabilizing selection is also observed if the polygenic system is at an equilibrium determined by a balance between selection and mutation (or migration) when both additive an[r] ... See full document

... space models (Sahlgren, 2006; Bullinaria and Levy, 2007; Pad´o and Lapata, 2007; Peirsman, 2008) capture the semantic similarity between two words on the basis of their distribution in a cor- ...these ... See full document

... pain models were sensitive to morphine analgesia compared to placebo: muscle pressure ...pain models were not sensitive to morphine analgesia: skin heat, rectal electrical stimulation, or rectal heat ... See full document

... two models can be compared using a likelihood ratio ...logit models therefore appear to outperform the equivalent GEV models in terms of ...logit models is not possible because the stochastic ... See full document

... exploit variation within mutations for Mendelian disorders in humans and elite populations; commercial plant and animal popula- animals, relatively little is known about the nature and tions are usually not based ... See full document

... Our study employed liver RNA-seq data from two experi- ments. We profiled liver RNA in males from the eight inbred founder strains of the DO population. We also profiled liver samples in a genetic mapping panel of 277 DO ... See full document

... Determining genotype-phenotype relationships is the heart of genetics. Understanding how the relationships between traits, genotypes, and environments are con- trolled is also crucial to find traits relevant to the ... See full document

... expression Quantitative Trait Locus (eQTL) analysis has been applied in yeast (Brem et ...phenotypic variation in the mapping population (Mackay, ... See full document

... positive lactobacilli ⫹ 0.70 ⫻ maximum count of Peptostrepto- coccus spp. Using this model, the predicted probability (p) is a number between 0 and 1. The area under the curve (AUC) has a value of 0.94, with a confidence ... See full document