[PDF] Top 20 ND10 Protein PML Is Recruited to Herpes Simplex Virus Type 1 Prereplicative Sites and Replication Compartments in the Presence of Viral DNA Polymerase
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ND10 Protein PML Is Recruited to Herpes Simplex Virus Type 1 Prereplicative Sites and Replication Compartments in the Presence of Viral DNA Polymerase
... The PML staining observed in stage III foci and in the replication com- partments in HEp2 cells is not due to cross-reactivity of the PML antibody with viral proteins, because no PML ... See full document
8
Interactions of Herpes Simplex Virus Type 1 with ND10 and Recruitment of PML to Replication Compartments
... that PML may be recruited only to a fully formed viral DNA replication complex like a replisome, a small factory of replication proteins (4, ...the viral DNA ... See full document
15
ND10 Components Relocate to Sites Associated with Herpes Simplex Virus Type 1 Nucleoprotein Complexes during Virus Infection
... an ND10 structure and/or a specific location at which a replication com- partment could begin to develop, upon reflection this model presents a significant ...the viral DNA becomes much less ... See full document
12
Characterization of nuclear structures in cells infected with herpes simplex virus type 1 in the absence of viral DNA replication.
... these sites. Spe- cifically, active viral polymerase may remove UL29 that is associated with cellular single-stranded ...in prereplicative sites is always associated with cel- lular ... See full document
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Identification of Rep-Associated Factors in Herpes Simplex Virus Type 1-Induced Adeno-Associated Virus Type 2 Replication Compartments
... early replication steps. It was surprising that no cellular polymerase was identified by MS, even in the case of cells infected with HSV ⌬ UL30, where a cellular enzyme is necessarily required (Table ... See full document
17
Processing of Lagging-Strand Intermediates In Vitro by Herpes Simplex Virus Type 1 DNA Polymerase
... cellular DNA synthesis to distinct sites for viral DNA replication pose another important question: how is it directed to viral replication compartments? One ... See full document
14
Inhibition of the Herpes Simplex Virus Type 1 DNA Polymerase Induces Hyperphosphorylation of Replication Protein A and Its Accumulation at S-Phase-Specific Sites of DNA Damage during Infection
... or DNA damage is known to serve as a signal for cellular DNA damage and to mark nuclear foci where DNA repair is occurring (39, 47; reviewed in reference ...the presence of the viral ... See full document
10
Pocket Protein p130/Rb2 Is Required for Efficient Herpes Simplex Virus Type 1 Gene Expression and Viral Replication
... with sites of early cellular DNA replication (31), al- though a direct role for p130 in DNA replication has not been ...of viral genomes to sites within the nucleus where ... See full document
12
ATR and ATRIP Are Recruited to Herpes Simplex Virus Type 1 Replication Compartments Even though ATR Signaling Is Disabled
... the herpes simplex virus type 1 (HSV-1) genome might be expected to induce a DNA damage response, the ATR kinase is not activated in infected ...both recruited to ... See full document
13
Herpes simplex virus type 1 prereplicative sites are a heterogeneous population: only a subset are likely to be precursors to replication compartments.
... the presence of ...the prereplicative site pattern formed in cells infected with wild-type virus in the presence of ...these sites could be considered intermediates in the ... See full document
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Mutations That Decrease DNA Binding of the Processivity Factor of the Herpes Simplex Virus DNA Polymerase Reduce Viral Yield, Alter the Kinetics of Viral DNA Replication, and Decrease the Fidelity of DNA Replication
... ences replication fidelity, we took advantage of the inserted lacZ reporter gene in the Cgal ⌬ 42 recombinant and its deriv- ...which viral stocks were prepared by inoculation of 100 PFU of the original ... See full document
8
DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants.
... The remaining mutants studied, all of which were DNA- at 39 C Table 1, fell into three categories with respect to their ability to induce DP activity at 39 C Table 2: i mutants belonging[r] ... See full document
10
Determination of Minimum Herpes Simplex Virus Type 1 Components Necessary To Localize Transcriptionally Active DNA to ND10
... potential protein intermediates between vi- ral DNA and ...the viral transcription at ND10 could be due to binding of ND10-asso- ciated proteins to the incoming viral origin of ... See full document
8
The Pre-NH2-Terminal Domain of the Herpes Simplex Virus 1 DNA Polymerase Catalytic Subunit Is Required for Efficient Viral Replication
... with virus at an MOI of 20 in triplicate, and cell lysates were harvested at 12 and 16 ...hpi. DNA from mock- and HSV-infected Vero cells was isolated and processed as described previously for murine ... See full document
9
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication.
... of herpes simplex virus genes requires the synthesis of functional ICP4, a nuclear phosphoprotein that contains a prominent serine-rich region between amino acids 142 and ...potential sites ... See full document
11
Formation of herpes simplex virus type 1 replication compartments by transfection: requirements and localization to nuclear domain 10.
... with ND10. Interestingly, Maul et al. have shown that HSV-1 DNA localizes adjacent to ND10 in the absence of viral transcription and translation ...that viral DNA and UL29 ... See full document
10
Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein.
... In the absence of viral DNA replication, HSV Pol colocalized with the HSV DNA-binding protein ICP8 in nuclear framework-associated structures called prereplicative sites.. In the presenc[r] ... See full document
8
Interaction of herpes simplex virus type 1 DNA polymerase and the UL42 accessory protein with a model primer template.
... Quantitative analysis of the interaction between the DNA polymerase subunits and HP96 by the gel mobility shift assay showed that in addition to altering the details of the nuclease prot[r] ... See full document
9
Purification of the herpes simplex virus type 1 65-kilodalton DNA-binding protein: properties of the protein and evidence of its association with the virus-encoded DNA polymerase.
... 8 Purification of the Herpes Simplex Virus Type 1 65-Kilodalton DNA-Binding Protein: Properties of the Protein and Evidence of Its Association with the Virus-Encoded DNA Polymerase MICHA[r] ... See full document
10
Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.
... Because of these results, we were concerned that further plaque purification and propagation on Pol A5 cells might give rise to wild-type virus that could confound further experiments. We therefore tested ... See full document
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