[PDF] Top 20 Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1.
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Regulation and cell-type-specific activity of a promoter located upstream of the latency-associated transcript of herpes simplex virus type 1.
... By using various fragments and deletion constructs, this promoter activity 3269 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest To identify promoter regions which contr[r] ... See full document
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Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type 1 required for cell-type-specific activity.
... Our current data demonstrate that the IC-1 factor is selectively present in the human neuroblastoma cells IMR-32 compared with HeLa cells and binds a DNA sequence which is selectively re[r] ... See full document
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Activity of herpes simplex virus type 1 latency-associated transcript (LAT) promoter in neuron-derived cells: evidence for neuron specificity and for a large LAT transcript.
... In summary, we have i used transient CAT assays in neuron-derived cells to map LAT-associated promoter activity to a location over 660 nucleotides upstream from the 5' end of the stable [r] ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... of latency is not yet ...LAT promoter during the acute stage of infection ...LAT promoter-positive neurons to wild-type levels ...of virus production and immediate-early gene expression ... See full document
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Enhancer and Long-Term Expression Functions of Herpes Simplex Virus Type 1 Latency-Associated Promoter Are both Located in the Same Region
... enhancer activity within the region upstream of the LAT ...background activity which was not significantly different from that of either of the control plasmids, pHB18 (P ⱖ ...enhancer ... See full document
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Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... the regulation of herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) expres- sion and processing in the absence of other cis and ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... LAT transcript and indicate that the reactivation phe- notype resides at the 5 * ...LAT promoter mutants indicated that transcription of LAT was required for induced reactivation, we sought to identify the ... See full document
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cis-acting elements involved in transcriptional regulation of the herpes simplex virus type 1 latency-associated promoter 1 (LAP1) in vitro and in vivo.
... of upstream sequence elements to transcrip- tional activity in ...moter activity has been analyzed by using sequences between positions 1 61 and 2 ...the upstream boundary of the ... See full document
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Evidence for a Bidirectional Element Located Downstream from the Herpes Simplex Virus Type 1 Latency-Associated Promoter That Increases Its Activity during Latency
... The activity of this plasmid was compared to that of two others in which the LTE was inserted in the context of an intron between the LAP and the lacZ gene, in either the forward (pHB22F) or the reverse (pHB22R) ... See full document
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The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... one type of posttranslational modification that can be present at specific histone amino acid residues, and acetylation of lysines 9 and 14 of histone H3 is typically enriched in transcriptionally permis- ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... with herpes simplex virus type 1 (HSV-1), an immune response is initiated resulting in significant infiltration of CD8 ⴙ T ...the latency-associated ... See full document
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The herpes simplex virus type 1 latency-associated transcript promoter is activated through Ras and Raf by nerve growth factor and sodium butyrate in PC12 cells.
... Herpes simplex virus establishes latent infections in the nuclei of sensory ...the latency-associated transcripts ...the regulation of LAT expression in neuronal and nonneuronal ... See full document
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In vivo epinephrine reactivation of ocular herpes simplex virus type 1 in the rabbit is correlated to a 370-base-pair region located between the promoter and the 5' end of the 2.0 kilobase latency-associated transcript.
... from virus following in vivo reactivation or explant ...rescuant virus were explanted. The DNA from reactivated virus was isolated, digested with restriction enzymes BglII and SalI, resolved through ... See full document
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Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... Herpes simplex virus type 1 (HSV-1) establishes latency in human sensory ganglia, during which time the viral genome is transcriptionally silent with the exception of the ... See full document
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CTCF-Dependent Chromatin Boundary Element between the Latency-Associated Transcript and ICP0 Promoters in the Herpes Simplex Virus Type 1 Genome
... is located between active and repressive chromatin, it may potentially provide the chromatin boundary to restrict the silenced chromatin from inactivating LAT transcription during latent infection or pre- vent the ... See full document
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In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... these cell lines may vary considerably in the quantity and specificity of their transcription ...of specific transcription factors compared with postmitotic ...the activity of each LAT ... See full document
7
Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... During latency, HSV-1 and HSV2-LAT-S1 did not re- activate ...lasting 1 to 2 days, similar in character to recurrences produced by HSV-2, HSV2-LAT-P1, and ...that specific neuronal factors may ... See full document
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Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... lishes latency in trigeminal ganglia (TG), while HSV-2 usually infects the genital epithe- lium and establishes latency in dorsal root ganglia (DRG) ...(15), type of sensations conveyed (16), and, ... See full document
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The nucleotide sequence, 5' end, promoter domain, and kinetics of expression of the gene encoding the herpes simplex virus type 2 latency-associated transcript.
... The 5619 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The sequence of the herpes simplex virus type 2 HSV-2 latency-associated transcript LAT region resembles that o[r] ... See full document
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Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... The 2-kb LAT RNA interacts with ribosomal proteins and splicing factors in vivo. Our studies indicate that LAT associ- ates strongly with members of the translational complex in the cytoplasm (Fig. 3 and 4). However, it ... See full document
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