[PDF] Top 20 Structure-function studies of the herpes simplex virus type 1 DNA polymerase.
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Structure-function studies of the herpes simplex virus type 1 DNA polymerase.
... In this report, we present an alignment of the amino acid sequence of HSV-1 pol into three distinct catalytic domains RNase H, 3'-5'-exonuclease, and DNA polymerase, respectively, evalua[r] ... See full document
11
The High Prevalence of Herpes Simplex Virus Type 1 DNA in Human Trigeminal Ganglia Is Not a Function of Age or Gender
... harbors herpes simplex virus type 1 (HSV-1), which can cause a variety of disorders (25, 27, ...progeny virus and also can shut down its own lytic replica- tion to ... See full document
5
Branched structures in the intracellular DNA of herpes simplex virus type 1.
... Herpes simplex virus type 1 (HSV-1) replication produces large intracellular DNA molecules that appear to be in a head-to-tail concatemeric ...these DNA species may ... See full document
7
Localization of the herpes simplex virus type 1 65-kilodalton DNA-binding protein and DNA polymerase in the presence and absence of viral DNA synthesis.
... 5738-5749 0022-538X/90/125738-12$02.00/0 Copyright C 1990, American Society for Microbiology Localization of the Herpes Simplex Virus Type 1 65-Kilodalton DNA-Binding Protein and DNA Pol[r] ... See full document
12
DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants.
... The remaining mutants studied, all of which were DNA- at 39 C Table 1, fell into three categories with respect to their ability to induce DP activity at 39 C Table 2: i mutants belonging[r] ... See full document
10
Expression of herpes simplex virus type 1 DNA polymerase gene by in vitro translation and effects of gene deletions on activity.
... The in vitro translated pol gene product was enzymatically active, with salt resistance and sensitivity to acyclovir triphosphate, similar to the enzyme activity in crude extracts of her[r] ... See full document
9
Repression of host RNA polymerase II transcription by herpes simplex virus type 1.
... viral DNA replication (reviewed in refer- ence ...viral DNA rep- lication and are expressed only after IE genes are activated (starting at approximately 3 h ... See full document
10
Assessing the contribution of the herpes simplex virus DNA polymerase to spontaneous mutations
... a virus which showed a 300- to 700-fold higher error rate than HSV-1 SC16 by the tk mu- tagenesis assay previously [21], was found to contain three mutations compared to the other HSV-2 pols, with one ... See full document
8
The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity.
... Since, as previously mentioned, UL42 is present in HSVinfected cells in large excess relative to the amount of Pol-UL42 complex, it was possible to purify UL42 free of detectable DNA pol[r] ... See full document
12
Two regions of the herpes simplex virus type 1 UL42 protein are required for its functional interaction with the viral DNA polymerase.
... Although a UL42 mutant RNA encoding a product lacking the 28 C-terminal residues resulted in wildtype levels of pol stimulation, the failure of large aminoterminal N-terminal and C-termi[r] ... See full document
10
Inhibition of herpes simplex virus type 1 DNA polymerase activity by peptides from the UL42 accessory protein is largely nonspecific.
... MARSDEN"* Medical Research Council Virology Unit, Church Street, Glasgow Gll SJR,' and Glaxo Group Research Ltd., Greenford, Middlesex UB6 OHE,2 United Kingdom, and Laboratory of Viral D[r] ... See full document
7
Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.
... BWr, a new acyclovir-resistant mutant derived from the Patton strain of herpes simplex virus type 1, induced a DNA polymerase resistant to inhibition by acyclovir triphosphate, but, unli[r] ... See full document
6
Purification of the herpes simplex virus type 1 65-kilodalton DNA-binding protein: properties of the protein and evidence of its association with the virus-encoded DNA polymerase.
... 8 Purification of the Herpes Simplex Virus Type 1 65-Kilodalton DNA-Binding Protein: Properties of the Protein and Evidence of Its Association with the Virus-Encoded DNA Polymerase MICHA[r] ... See full document
10
Expression of herpes simplex virus type 1 DNA polymerase in Saccharomyces cerevisiae and detection of virus-specific enzyme activity in cell-free lysates.
... Cell extracts from a strain of Saccharomyces cerevisiae harboring this vector Y-MH202, expresser cells grown in the presence of galactose and assayed in high salt 100 mM ammonium sulfate[r] ... See full document
6
Nonstructural proteins of herpes simplex virus. I. Purification of the induced DNA polymerase.
... Thus, DEAE-cellulose and phosphocellulose chromatography were used in combination with affinity chromatography to purify DNA polymerase from herpes simplex virus type 1- and type 2-infec[r] ... See full document
9
Inhibition of Translation by a Short Element in the 5′ Leader of the Herpes Simplex Virus 1 DNA Polymerase Transcript
... the pol 5 ⬘ leader (Fig. 5, pol ⌬ 54.x). We also generated a second recombinant virus by restoring pol in HP66 with the wild-type pol ORF sequence and the wild-type pol 5 ⬘ UTR (Fig. 5, wt.x). We ... See full document
9
A Mutation in the DNA Polymerase Accessory Factor of Herpes Simplex Virus 1 Restores Viral DNA Replication in the Presence of Raltegravir
... The herpes simplex virus 1 F strain [HSV-1(F)], referred to as the wild type in this study, was from Bernard Roizman ...(14). Herpes simplex virus 2 strain G ... See full document
9
Finger Domain Mutation Affects Enzyme Activity, DNA Replication Efficiency, and Fidelity of an Exonuclease-Deficient DNA Polymerase of Herpes Simplex Virus Type 1
... A DNA polymerase with intrinsic exonucleolytic proofreading can have 10- to 100-fold higher DNA replication fidelity than a polymerase that lacks proofreading activity ...viral DNA ... See full document
8
Interaction with nucleic acids and stimulation of the viral DNA polymerase by the herpes simplex virus type 1 major DNA-binding protein.
... 727 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The interaction of the herpes simplex virus type 1 HSV-1 major DNA-binding protein, infected-cell polypeptide 8 ICP8[r] ... See full document
7
In vitro mutagenesis of the herpes simplex virus type 1 DNA polymerase gene results in altered drug sensitivity of the enzyme.
... Despite this fact, the approximately 63-fold increase in ACV-TP resistance and the approximately 6-fold increase in PAA sensitivity shown for the mutant HSV-1 pol enzyme in the present s[r] ... See full document
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