[PDF] Top 20 The Pre-NH2-Terminal Domain of the Herpes Simplex Virus 1 DNA Polymerase Catalytic Subunit Is Required for Efficient Viral Replication
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The Pre-NH2-Terminal Domain of the Herpes Simplex Virus 1 DNA Polymerase Catalytic Subunit Is Required for Efficient Viral Replication
... HSV-1 DNA replication is car- ried out within the infected cell has yet to be fully ...Following DNA melting at the origin of replication, HSV-1 DNA synthesis is ... See full document
9
Pin1 Interacts with the Epstein-Barr Virus DNA Polymerase Catalytic Subunit and Regulates Viral DNA Replication
... EBV DNA polymerase BALF5 enzyme at Thr178. The polymerase contains conserved domains, including polymerase catalytic and exonu- clease domains at the C terminus, but the sequence around ... See full document
8
A Mutation in the DNA Polymerase Accessory Factor of Herpes Simplex Virus 1 Restores Viral DNA Replication in the Presence of Raltegravir
... the replication of four different herpesviruses, herpes simplex virus 1 (HSV-1), HSV-2, HCMV, and mouse cytomegalovi- rus, by 30- to 700-fold, depending on the dose and the ... See full document
9
The catalytic subunit of the DNA polymerase of herpes simplex virus type 1 interacts specifically with the C terminus of the UL8 component of the viral helicase-primase complex.
... The herpes simplex virus type 1 (HSV-1) UL8 DNA replication protein is a component of a trimeric helicase-primase ...the catalytic subunit of the ... See full document
8
Release of the catalytic domain N(o) from the herpes simplex virus type 1 protease is required for viral growth.
... m100 virus, while mutant protease molecules were provided from transfected ...simian virus 40 early gene pro- moter (pSVPra) complemented the growth of ...for viral replication, since the ... See full document
9
Herpes Simplex Virus 1 ICP22 but Not US1.5 Is Required for Efficient Acute Replication in Mice and VICE Domain Formation
... ⫻stop virus may contribute to its impaired acute replication in ...HSV-1 replication and how ICP22 facilitates their formation. While VICE domain formation is affected in 3 ⫻stop- ... See full document
10
The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication
... cellular DNA damage response (DDR) pathways, which sense troublesome DNA structures formed during ...is pre- ...with viral replication compartments and in the cytoplasm associated with ... See full document
16
ND10 Protein PML Is Recruited to Herpes Simplex Virus Type 1 Prereplicative Sites and Replication Compartments in the Presence of Viral DNA Polymerase
... a virus lacking the polymerase, but they do not contain ...a polymerase null mutant to recruit PML into stage III ...the polymerase accessory factor, is respon- sible for the recruitment of ... See full document
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The herpes simplex virus type 1 UL42 gene product: a subunit of DNA polymerase that functions to increase processivity.
... Genetic experiments have shown that the products of the herpes simplex virus type 1 (HSV-1) DNA polymerase (UL30) and UL42 genes are both required for viral DNA replication, and a number[r] ... See full document
12
Effects of mutations in the Exo III motif of the herpes simplex virus DNA polymerase gene on enzyme activities, viral replication, and replication fidelity.
... The herpes simplex virus DNA polymerase catalytic subunit, which has intrinsic polymerase and 3 * -5 * exonuclease activities, contains sequence motifs that are ... See full document
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Finger Domain Mutation Affects Enzyme Activity, DNA Replication Efficiency, and Fidelity of an Exonuclease-Deficient DNA Polymerase of Herpes Simplex Virus Type 1
... The catalytic subunit of herpes simplex virus DNA polymerase (Pol), a member of the B family polymerases, possesses both polymerase and exonuclease ...recombinant ... See full document
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Dephosphorylation of eIF-2α Mediated by the γ134.5 Protein of Herpes Simplex Virus Type 1 Is Required for Viral Response to Interferon but Is Not Sufficient for Efficient Viral Replication
... nal domain of the ␥ 1 ...carboxyl-terminal domain of the ␥ 1 ...is required to prevent the shutoff of protein synthesis (8, 12, 19, ...the domain containing amino acids 53 ... See full document
8
Requirement of the N-Terminal Activation Domain of Herpes Simplex Virus ICP4 for Viral Gene Expression
... for Viral Gene Expression Lauren ...of herpes simplex virus (HSV) ...for viral gene expression, including a DNA binding domain and transactivation domains that are ... See full document
9
Herpes simplex virus type 1 alkaline nuclease is required for efficient processing of viral DNA replication intermediates.
... well DNA from both mutant- and wild-type-infected cells following XbaI ...linear DNA represents several different fragments ranging from 24 to approximately 62 kb which are not resolved on this ... See full document
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DNA Mismatch Repair Proteins Are Required for Efficient Herpes Simplex Virus 1 Replication
... 2011 Herpes simplex virus 1 (HSV-1) is a double-stranded DNA virus that replicates in the nucleus of its human host cell and is known to interact with many cellular ... See full document
13
Elimination of Mitochondrial DNA Is Not Required for Herpes Simplex Virus 1 Replication
... with herpes simplex virus type 1 (HSV-1) results in the rapid elimination of mitochondrial DNA (mtDNA) from host ...the viral alkaline nuclease (UL12) called ...on ... See full document
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The influenza A virus PB2 polymerase subunit is required for the replication of viral RNA.
... the terminal sequences of the NS viral segment, and were of negative or positive polarity, ...cRNA replication intermediate and mRNA accumulated when the system was reconstituted with vNSZ ...the ... See full document
5
Structures of herpes simplex virus type 1 genes required for replication of virus DNA.
... Recently, a method has been developed to identify regions in the genome of herpes simplex virus type 1 (HSV-1) which contain genes required for DNA synthesis from an HSV-1 origin of DNA [r] ... See full document
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Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system.
... The Ung- viruses established latency in 100% of the animals tested (Table 2), but a reduced viral genome burden was observed in latently infected TG (Fig. It is not yet clear whether the[r] ... See full document
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Viral replication is required for induction of ocular immunopathology by herpes simplex virus.
... whereby virus infections induce immune reactions that subse- quently involve self components (34, ...of virus replication in initiating ...although virus and demon- strable antigens are absent ... See full document
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