[PDF] Top 20 Accumulation of Viral Transcripts and DNA during Establishment of Latency by Herpes Simplex Virus
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Accumulation of Viral Transcripts and DNA during Establishment of Latency by Herpes Simplex Virus
... wild-type herpes simplex virus is established during an acute phase of ganglionic infection in which there is abundant viral replication and productive-cycle gene ...resembles ... See full document
9
Herpes Simplex Virus 2 MicroRNA miR-H6 Is a Novel Latency-Associated Transcript-Associated MicroRNA, but Reduction of Its Expression Does Not Influence the Establishment of Viral Latency or the Recurrence Phenotype
... The herpes simplex virus 2 (HSV-2) viral microRNA (miRNA) designated miR-H6 is located upstream of the latency-associated transcript (LAT) promoter region on the strand opposite the ... See full document
9
Herpes Simplex Virus Type 1 Latency-Associated Transcripts Suppress Viral Replication and Reduce Immediate-Early Gene mRNA Levels in a Neuronal Cell Line
... During herpes simplex virus type 1 (HSV-1) latent infection in human dorsal root ganglia, limited viral transcription, which has been linked to HSV-1 reactivation ability, takes ...in ... See full document
9
Herpes Simplex Virus Type 1 Promoter Activity during Latency Establishment, Maintenance, and Reactivation in Primary Dorsal Root Neurons In Vitro
... activity, viral genomes are harbored in neurons and can be induced to acti- vate lytic phase promoters using NGF withdrawal (49) or ad- dition of ...reactivation during the first 22 h postexplant by ... See full document
11
PrPc Expression Influences the Establishment of Herpes Simplex Virus Type 1 Latency
... In our study we have utilized the TUNEL assay, which de- tects fragmented DNA, to measure apoptosis. It has been suggested that TUNEL identifies cells that have undergone not only apoptosis but also necrosis and ... See full document
12
Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation
... The viral ribonucleotide reductase activity becomes important, however, for viral DNA replica- tion in neurons and nondividing cells or at elevated temperatures ...this viral enzyme complex is ... See full document
12
Herpes Simplex Virus Type 1 Latently Infected Neurons Differentially Express Latency-Associated and ICP0 Transcripts
... of herpes simplex virus type 1 (HSV-1) infection, the latency-associated transcripts (LATs) are the most abundant viral transcripts present in neurons, but some ... See full document
12
The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... transgene DNA, LATpa DNA (Fig. 1), included a 5,277-bp genomic DNA fragment of HSV-2 strain 333 consisting of the sequences 1,167 bp upstream and 4,114 bp downstream of the LAT transcription ... See full document
7
A viral function represses accumulation of transcripts from productive-cycle genes in mouse ganglia latently infected with herpes simplex virus.
... of herpes simplex virus (HSV) with the mammalian nervous system that results in virus latency is prob- ably the most fascinating biological property of the ...latent virus evades ... See full document
7
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... of viral mutants. The parental virus for ⌬LAT-EGFP was dLAT2903, a mutant of HSV-1 strain McKrae containing a ...dLAT2903 DNA and a plasmid containing the entire structural gene for EGFP, using ... See full document
7
Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... the establishment or the maintenance of ...the DNA region, upstream of the ...HSV DNA derived from latently infected trigeminal ganglia (12); the possibility that specific regions were methyl- ated ... See full document
6
Herpes Simplex Virus type 1 lytic viral gene expression during the establishment and maintenance of latency
... whole viral genome preparation used was approximately 61 plaques per µg of DNA (data not shown), less than the 100-1000 plaques per µg of viral DNA recommended for the generation of ... See full document
353
Influence of Herpes Simplex Virus 1 Latency-Associated Transcripts on the Establishment and Maintenance of Latency in the ROSA26R Reporter Mouse Model
... CMVCre⌬LAT-GFP-revertant virus designated HSV CMVCreREV ...infectious virus titers at 3, 5, and 7 ...of latency establishment within BALB/c DRG in comparison to the previously characterized ... See full document
11
Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... ABSTRACT Herpes simplex virus (HSV) latency in neurons remains poorly under- stood, and the heterogeneity of the sensory nervous system complicates mechanis- tic ...express ... See full document
15
Herpes Simplex Virus ICP0 Promotes both Histone Removal and Acetylation on Viral DNA during Lytic Infection
... leukemia virus 1 promoters occur in- dependently of transcription (46, 68, 69, ...the DNA for transcription factor binding is consistent with its role in promoting the expression of genes in the context of ... See full document
9
The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... simian virus 40 (SV40) polyadenylation sequences derived from PCH110 (See ...This virus ex- presses b-gal in at least some neurons for up to 6 months ... See full document
9
ICP0 antagonizes Stat 1 dependent repression of herpes simplex virus: implications for the regulation of viral latency
... the latency-associated transcript (LAT), the long-short spanning transcript (L/ST), infected cell protein 0 (ICP0), and infected cell protein ...A viral pro- tein, ICP4, blocks the transcription of the LAT ... See full document
23
Evidence that the herpes simplex virus type 1 uracil DNA glycosylase is required for efficient viral replication and latency in the murine nervous system.
... Assessment of the latent viral DNA burden by quantitative PCR QPCR demonstrated a reduction in the number of copies of the Ung- mutant viral Downloaded from http://jvi.asm.org/ on Novemb[r] ... See full document
10
Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcripts.
... Since mutational analyses proved the ATF/CREB sequence in 2LATP to be active, its response to cAMP was tested in PC12 cells by using plasmid p-195 and its derivative, p-195CREM1. The mutation in p-195CREM1 was the same ... See full document
8
Herpes Simplex Virus DNA Synthesis Is Not a Decisive Regulatory Event in the Initiation of Lytic Viral Protein Expression in Neurons In Vivo during Primary Infection or Reactivation from Latency
... of viral genetic information within the neurons of the host nervous ...the virus but remain ...by viral DNA synthesis (10). Our data demonstrate that (i) viral TK-dependent viral ... See full document
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