[PDF] Top 20 Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome
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Adeno-Associated Virus Type 2 Rep68 Can Bind to Consensus Rep-Binding Sites on the Herpes Simplex Virus 1 Genome
... of Rep68/Rep78-me- Received 27 May 2015 Accepted 11 August 2015 Accepted manuscript posted online 19 August 2015 Citation Seyffert M, Glauser DL, Tobler K, Georgiev O, Vogel R, Vogt B, Agúndez L, Linden M, Büning ... See full document
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Binding sites for adeno-associated virus Rep proteins within the human genome.
... the consensus Rep bind- ing site ...containing Rep binding sites from a pool of randomly generated ...Their consensus se- quence has two GAGC boxes in the ...containing ... See full document
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Inhibition of Herpes Simplex Virus Type 1 Replication by Adeno-Associated Virus Rep Proteins Depends on Their Combined DNA-Binding and ATPase/Helicase Activities
... Vero 2-2 cells express ICP27, the cotransfection of an ICP27-expressing plasmid is required for high titers of HSV-1 amplicon vector stocks ...HSV-1 genome, we ensured that replication ... See full document
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Rep-Dependent Initiation of Adeno-Associated Virus Type 2 DNA Replication by a Herpes Simplex Virus Type 1 Replication Complex in a Reconstituted System
... AAV Rep68 and the products of the HSV-1 UL5, UL8, UL52, UL29, UL30, and UL42 genes that is dependent on the AAV origins of DNA ...of Rep68 and the products of the UL30, UL42, and UL29 ...with ... See full document
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Recombinant adeno-associated virus type 2 replication and packaging is entirely supported by a herpes simplex virus type 1 amplicon expressing Rep and Cap.
... expressing Rep from the p5 and p19 promoters and made with wt HSV-1 helper virus (HSV-RC/ KOS) can support rescue and replication of rAAV ...pressing Rep and Cap was to successfully ... See full document
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Herpes Simplex Virus Type 1 ICP0 Protein Mediates Activation of Adeno-Associated Virus Type 2 rep Gene Expression from a Latent Integrated Form
... 2004 Adeno-associated virus type 2 (AAV-2) is a human parvovirus that requires the presence of a helper virus, such as the herpes simplex virus ... See full document
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Determination of adeno-associated virus Rep68 and Rep78 binding sites by random sequence oligonucleotide selection.
... These consensus sequences more closely resemble the binding sites identified in the AAV ITR and the AAVS1 sequence (7, 16, ...for Rep binding contains tandem repeats of GAGC, stable ... See full document
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Adeno-Associated Virus Type 2 Modulates the Host DNA Damage Response Induced by Herpes Simplex Virus 1 during Coinfection
... in virus-infected cells and mock-infected cells ...to sites of DNA damage (89, 106), and (iii) analyzing the phosphor- ylation status of the ATR target ...iments can be summarized as ...FIG 1 ... See full document
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Negative regulation of the adeno-associated virus (AAV) P5 promoter involves both the P5 rep binding site and the consensus ATP-binding motif of the AAV Rep68 protein.
... wild-type Rep68 to inhibit P 5 transcript levels, even in the presence of a mutated P 5 RRS, which did not allow Rep68 binding in ...remaining Rep68-mediated re- pression was due to ... See full document
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Impact of the Interaction between Herpes Simplex Virus Type 1 Regulatory Protein ICP0 and Ubiquitin-Specific Protease USP7 on Activation of Adeno-Associated Virus Type 2 rep Gene Expression
... the herpes simplex virus type 1 (HSV-1) regulatory protein ICP0 in transfected cells reacti- vates rep gene expression from integrated adeno-associated ... See full document
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Herpes Simplex Virus Type 1/Adeno-Associated Virus rep+ Hybrid Amplicon Vector Improves the Stability of Transgene Expression in Human Cells by Site-Specific Integration
... the rep gene will worsen the infec- tions of HSV or adenovirus, since the role of Rep proteins is to suppress rather than enhance the DNA replication of these two ...that Rep from the transduced ... See full document
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Live Covisualization of Competing Adeno-Associated Virus and Herpes Simplex Virus Type 1 DNA Replication: Molecular Mechanisms of Interaction
... competing adeno- associated virus (AAV) and herpes simplex virus type 1 (HSV-1) DNA ...AAV Rep is recruited into AAV replication compartments but not ... See full document
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Herpes Simplex Virus Type 1/Adeno-Associated Virus Hybrid Vectors Mediate Site-Specific Integration at the Adeno-Associated Virus Preintegration Site, AAVS1, on Human Chromosome 19
... Herpes simplex virus type 1 (HSV-1)-based amplicon vectors have a large transgene capacity and can efficiently infect many different cell ...on ... See full document
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Impact of the MRN Complex on Adeno-Associated Virus Integration and Replication during Coinfection with Herpes Simplex Virus 1
... ABSTRACT Adeno-associated virus (AAV) is a helper-dependent parvovirus that requires coinfection with adenovirus (AdV) or herpes sim- plex virus 1 (HSV-1) to ...helper ... See full document
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Identification of Rep-Associated Factors in Herpes Simplex Virus Type 1-Induced Adeno-Associated Virus Type 2 Replication Compartments
... with Rep within AAV RCs even in the presence of the HSV-1 polymerase ...is associated with the recruitment of components of the Mre11/Rad50/Nbs1 complex, Ku70 and -86, and the mismatch repair ... See full document
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The adeno-associated virus rep gene suppresses herpes simplex virus-induced DNA amplification.
... The adeno-associated virus rep gene inhibits replication of an adeno-associated virus/ simian virus 40 hybrid genome in cos-7 cells. Adeno- associated virus gene expression inhibits cell[r] ... See full document
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The Genome Sequence of Herpes Simplex Virus Type 2
... genomes can be broad- ened: as already noted, both HSV-1 and HSV-2 sequences possess many ORFs in addition to those in the canonical gene ...data can be viewed in two complementary ... See full document
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Sequence requirements for binding of Rep68 to the adeno-associated virus terminal repeats.
... the Rep protein, albeit with lower ...relative binding affinity of linear substrates containing a complete RBE with hairpinned substrates and found that linear substrates bound Rep less ...to ... See full document
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DNA-Binding Activity of Adeno-Associated Virus Rep Is Required for Inverted Terminal Repeat-Dependent Complex Formation with Herpes Simplex Virus ICP8
... of Rep and ICP8 in nuclear repli- cation domains depends on the ability of Rep to bind and unwind the AAV ITR, generating ssDNA ...of Rep are needed as such for ternary-complex formation as ... See full document
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Sequence requirements for stable binding and function of Rep68 on the adeno-associated virus type 2 inverted terminal repeats.
... While these data show that Rep68 is able to bind to nonhairpin derivatives of the ITR and identify some of the features required for binding of Rep68 to DNA, this ability of Rep68 to bin[r] ... See full document
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