[PDF] Top 20 Comparison of Hepatitis C Virus NS5b and 5′ Noncoding Gene Sequencing Methods in a Multicenter Study
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Comparison of Hepatitis C Virus NS5b and 5′ Noncoding Gene Sequencing Methods in a Multicenter Study
... evaluation study was performed in 11 specialized laboratories with the objective of assessing their capacities to genotype hepatitis C virus (HCV) and define the applicability of a given ... See full document
7
Clinical Evaluation of Two Methods for Genotyping Hepatitis C Virus Based on Analysis of the 5′ Noncoding Region
... the 5⬘NC region that were clearly type 1 by analysis of the NS5B ...These sequencing results were reproducible, and little or no polymorphism at key sites within these regions was observed in the ... See full document
7
Sequencing Analysis of NS3/4A, NS5A, and NS5B Genes from Patients Infected with Hepatitis C Virus Genotypes 5 and 6
... genotype 5 and 6 HCV, a robust PCR amplification and sequencing assay of viral target genes, such as NS3/4A, NS5A, and NS5B, is ...this study, primers were developed to amplify NS3/4A, NS5A, ... See full document
7
Comparison of Hepatitis C Virus Genotyping by 5′ Noncoding Region and Core Based Reverse Transcriptase PCR Assay with Sequencing and Use of the Assay for Determining Subtype Distribution in India
... this virus was unavail- able for follow-up and, hence, the origin of the virus could not be ...present study. One isolate, S9, showed a different branching in the 5⬘NCR tree (type 4) than that ... See full document
5
Hepatitis C Virus Genotyping Using an Oligonucleotide Microarray Based on the NS5B Sequence
... center study of 597 treated patients showed that subtypes 1b, 4a, and 4d were independent predictors of SVR ...recent study also demonstrated that patients infected with HCV sub- type 1b had a higher ... See full document
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Analysis of the 5′ Noncoding Region versus the NS5b Region in Genotyping Hepatitis C Virus Isolates from Blood Donors in France
... this study shows that subtype 1a was the most ...recent study (3) showing not only that sub- type 1a strains were predominant but also that their distribu- tion has been stable in blood donors in ... See full document
6
High Prevalence of Hepatitis C Virus Type 5 in Central France Evidenced by a Prospective Study from 1996 to 2002
... (iii) Comparison of serotyping and genotyping for 39 pa- ...both methods, thereby allowing a comparison of the two ...cases, sequencing of both the 5⬘ UTR and the NS5B ... See full document
6
Use of Sequence Analysis of the NS5B Region for Routine Genotyping of Hepatitis C Virus with Reference to C/E1 and 5′ Untranslated Region Sequences
... upon sequencing of ...core gene sequence was determined for three of ...only 5 ⬘ UTR, C, and E1 se- quences are available ...in C/E1. QC264 in NS5B did not group with previously ... See full document
11
Comparative performance evaluation of hepatitis C virus genotyping based on the 5' untranslated region versus partial sequencing of the NS5B region of brazilian patients with chronic hepatitis C
... our study, the 5 ’ UTR-based genotyping method (LiPA) showed higher efficiency than the NS5B region to generate PCR amplification ...the 5 ’ UTR, which is a highly conserved region, pro- duce ... See full document
5
Evaluation of a New Assay in Comparison with Reverse Hybridization and Sequencing Methods for Hepatitis C Virus Genotyping Targeting Both 5′ Noncoding and Nonstructural 5b Genomic Regions
... genotyping methods, such as automated reverse hybridization (29) and semiautomated sequencing (10, 11), need a previously amplified genomic product as starting ...Since 5 ⬘ NC amplification is ... See full document
6
Prevalence of amino acid mutations in hepatitis C virus core and NS5B regions among Venezuelan viral isolates and comparison with worldwide isolates
... the 5' non-coding region [6], core and/or NS5B [7]. The NS5B amplicons were gen- erated previously ...for sequencing and all sequences were per- formed by Macrogen Service Center, Seoul, ... See full document
7
Cooperation between the Hepatitis C Virus p7 and NS5B Proteins Enhances Virion Infectivity
... govern hepatitis C virus (HCV) assembly, release, and infectivity are still not yet fully under- ...present study, we sequenced a genotype 2A strain of HCV (JFH-1) that had been cell culture ... See full document
11
cis-Acting RNA Signals in the NS5B C-Terminal Coding Sequence of the Hepatitis C Virus Genome
... the 5⬘ and 3⬘ NTRs of viral RNAs, recently the presence of such elements in the coding sequences of a variety of viral RNA genomes has also been ...Theiler’s virus (35), and mengovirus ...human virus ... See full document
13
Evaluation of Accumulation of Hepatitis C Virus Mutations in a Chronically Infected Chimpanzee: Comparison of the Core, E1, HVR1, and NS5b Regions
... Four hepatitis C virus genome regions (the core, E1, HVR1, and NS5b) were amplified and sequenced from yearly samples obtained from a chronically infected chimpanzee over a 12-year ...the ... See full document
6
Hepatitis C Virus Replication Is Modulated by the Interaction of Nonstructural Protein NS5B and Fatty Acid Synthase
... Hepatitis C virus (HCV) nonstructural protein 5B (NS5B) is an RNA-dependent RNA polymerase (RdRp) that acts as a key player in the HCV replication ...this study, the NS5B protein ... See full document
11
Biochemical properties of hepatitis C virus NS5B RNA-dependent RNA polymerase and identification of amino acid sequence motifs essential for enzymatic activity.
... complete NS5B gene and included 54 nucleotides of the 3 9 nontranslated ...region. NS5B proteins with six histidine residues at their amino termini were translated from plasmid ...complete ... See full document
13
Expression of the herpes simplex virus type 1 glycoprotein C gene requires sequences in the 5' noncoding region of the gene.
... In previous studies using recombinant viruses, we demonstrated that sequences between -1350 and +30 relative to the start of gC transcription regulate 13-Gal as a viral late gene and tha[r] ... See full document
5
Human VAP-B Is Involved in Hepatitis C Virus Replication through Interaction with NS5A and NS5B
... apolipoprotein A1 (40), amphiphysin II (56), and vesicle-asso- ciated membrane protein (VAMP)-associated protein (VAP) subtype A (VAP-A), also called VAP-33 (48). Host fatty acids and geranylgeranylation appear to ... See full document
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Interaction of polypyrimidine tract-binding protein with the 5' noncoding region of the hepatitis C virus RNA genome and its functional requirement in internal initiation of translation.
... HCV 5 9 NCR, and the intensity of this complex increased as a function of protein concentration ...(lanes 5 and 6). These results show interaction of 5 9 NCR with the PTB moiety in the GST-PTB fusion ... See full document
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2-ARYL-3-(5-PHENYL[1,2,4]TRIAZOLO[4,3-C]QUINAZOLIN-3-YL)-1,3-THIAZOLIDIN-4-ONES AS HCV NS5B RNA POLYMERASE INHIBITORS
... Sigma–Aldrich chemicals are used as such without further purification. Purified reagent grade solvents are used for the synthetic, spectroscopic and physical studies. Progress of the reaction and purity of the compounds ... See full document
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