[PDF] Top 20 The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for function.
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The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for function.
... Binding of the herpes simplex virus type 1 UL9 gene product to an origin of viral DNA replication.. Nucleic Acids Res.[r] ... See full document
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Helicase Motif Ia Is Involved in Single-Strand DNA-Binding and Helicase Activities of the Herpes Simplex Virus Type 1 Origin-Binding Protein, UL9
... multifunctional protein essential for herpes simplex virus type 1 (HSV-1) replication in ...vivo. UL9 is a member of the superfamily II helicases and exhibits ... See full document
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Phosphorylation of the Herpes Simplex Virus Type 1 Origin Binding Protein
... The herpes simplex virus type 1 (HSV-1) origin binding protein (OBP), the product of the UL9 gene, is one of seven HSV-encoded proteins required for ... See full document
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Direct Interaction between the N- and C-Terminal Portions of the Herpes Simplex Virus Type 1 Origin Binding Protein UL9 Implies the Formation of a Head-to-Tail Dimer
... of UL9. Several questions remain about the reg- ulation of UL9 during HSV-1 DNA ...a UL9-dependent and a UL9-independent ...the UL9-independent second stage of infection, we ... See full document
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Genome Replication and Progeny Virion Production of Herpes Simplex Virus Type 1 Mutants with Temperature-Sensitive Lesions in the Origin-Binding Protein
... the virus-encoded factors essential for herpes sim- plex virus type 1 (HSV-1) DNA replication (5, 6, 9, 42) is the UL9 gene product (13), which due to its affinity for the ... See full document
6
DNA Binding Activity of the Herpes Simplex Virus Type 1 Origin Binding Protein, UL9, Can Be Modulated by Sequences in the N Terminus: Correlation between Transdominance and DNA Binding
... of UL9 truncations. The N-terminal domain of UL9 is depicted as an open box, and the C terminus is depicted as a gray ...seven conserved motifs of superfamily II helicases are depicted as ... See full document
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Properties of the novel herpes simplex virus type 1 origin binding protein, OBPC.
... FIG. 1. Diagrams of the structures of full-length OBP (the product of the UL9 gene, pCMVUL9), OBPC (the product of the ...pCMVOBPC 1 ), and mutant polypeptides OBPC D Nco (pCMVOBPC D Nco) and 9CT ... See full document
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Origin Binding Protein-Containing Protein-DNA Complex Formation at Herpes Simplex Virus Type 1 oriS: Role in oriS-Dependent DNA Replication
... six conserved heli- case motifs, the ATP-binding and leucine zipper motifs, as well as domains that mediate interactions with a component of the helicase-primase complex (UL8) and the ... See full document
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Packaging Determinants in the UL11 Tegument Protein of Herpes Simplex Virus Type 1
... of herpes simplex virus type 1 encodes a 96-amino-acid tegument protein that is myristylated, palmitylated, and phosphorylated and is found on the cytoplasmic faces of nuclear, ... See full document
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Use of transdominant mutants of the origin-binding protein (UL9) of herpes simplex virus type 1 to define functional domains.
... by binding origin DNA into an inactive ...interest. Motifs I and II are believed to be involved in ATP binding and hydrolysis, since they contain the estab- lished ATP-binding consensus ... See full document
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Intercellular Trafficking of VP22, a Herpes Simplex Virus Type 1 Tegument Protein
... Construction of pGFP-VP22 plasmid. pGFP- VP22 was constructed by in frame ligation of BamH1-Xba1 fragment of pVP22/myc-His2 (Invitrogen, Carlsbad, CA, USA), a commercially available VP22 expression vector that contains ... See full document
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Unusual lectin-binding properties of a herpes simplex virus type 1-specific glycoprotein.
... The resulting mixture was subjected to centrifugation for 60 min at 100,000 x g, and the supernatant was studied by Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Lysa[r] ... See full document
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Evidence that neomycin inhibits binding of herpes simplex virus type 1 to the cellular receptor.
... Time courses of HSV-1 receptor binding and internalization compared with effect of neomycin addition at various times postinfection.. Receptor-bound virus at various times postinfection [r] ... See full document
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Structure-function studies of the herpes simplex virus type 1 DNA polymerase.
... In this report, we present an alignment of the amino acid sequence of HSV-1 pol into three distinct catalytic domains RNase H, 3'-5'-exonuclease, and DNA polymerase, respectively, evalua[r] ... See full document
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Kinetics of expression of the gene encoding the 65-kilodalton DNA-binding protein of herpes simplex virus type 1.
... To characterize more thoroughly the kinetics with which the 65KDBP gene is expressed, we have examined not only the accumulation of 6SKDBP mRNA and protein, as compared to other well-cha[r] ... See full document
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Thermolabile in vivo DNA-binding activity associated with a protein encoded by mutants of herpes simplex virus type 1.
... 3 Thermolabile In Vivo DNA-Binding Activity Associated with a Protein Encoded by Mutants of Herpes Simplex Virus Type 1 Received 30 December 1982/Accepted 17 March 1983 The major DNA-bin[r] ... See full document
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Inhibition of Herpes Simplex Virus Type 1 Replication by Adeno-Associated Virus Rep Proteins Depends on Their Combined DNA-Binding and ATPase/Helicase Activities
... ATM protein kinase activity is activated upon DNA damage stimuli, and this activation has been attributed to intermolec- ular autophosphorylation on serine 1981 and dissociation of multimeric ATM to an active, ... See full document
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DNA binding and gene regulation by the herpes simplex virus type 1 protein ICP4 and involvement of the TATA element.
... The regions of the herpes simplex virus type 1 immediate early protein Vmw 175 required for site specific DNA binding closely correspond to those involved in transcriptional regulation..[r] ... See full document
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Herpes Simplex Virus Type 1 DNA-Packaging Protein UL17 Is Required for Efficient Binding of UL25 to Capsids
... UL17-stop virus contains a 16-bp insertion at position 32718 in the HSV-1 strain 17 genome, with stop codons in all three reading frames, truncating the UL17 open reading frame after codon 260 ...with ... See full document
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Physical map of the origin of defective DNA in herpes simplex virus type 1 DNA.
... The disappearance of the 5.4- to 5.7-Mdal EcoRI dDNA fragments after digestion with BamHI and the appearance of a new cluster of fragments, 2.6 to 3.2 Mdal, plus two 1-Mdal fragments B2 [r] ... See full document
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