[PDF] Top 20 In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
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In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... recombinant virus KOS/1 has been described previously ...The promoter consists of a SmaI-to-SacII DNA restriction fragment which extends to bp 2863 relative to the LAT transcription start ...The ... See full document
7
The activity of the pseudorabies virus latency-associated transcript promoter is dependent on its genomic location in herpes simplex virus recombinants as well as on the type of cell infected.
... 1972-1976 0022-538X/94/$04.00 + 0 Copyright © 1994, American Society for Microbiology The Activity of the Pseudorabies Virus Latency-Associated Transcript Promoter Is Dependent on Its Ge[r] ... See full document
5
Analysis of Protein Expression from within the Region Encoding the 2.0-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1
... (Fig. 1) served as the parental construct from which all other clones were ...XcmI deletion (36) to produce plasmids pLAT(H)GFP⫹ and pLAT(X)GFP⫹, ...CMV promoter was deleted from pLAT(H)GFP⫹ to ... See full document
14
A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
... Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.. Expression of her[r] ... See full document
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The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... Herpes simplex virus type 1 (HSV-1) is neurotropic virus capable of forming latent infections for the lifetime of an ...During latency, transcription is restricted ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... HSV latency is less ...antigen associated with major histocompatibility complex class I, thereby allowing infected cells to evade cell-mediated immu- nity ... See full document
7
The herpes simplex virus type 1 latency-associated transcript promoter is activated through Ras and Raf by nerve growth factor and sodium butyrate in PC12 cells.
... LAT promoter induction in the HSV life ...LAT promoter is induced in response to increases in gangli- onic levels of NGF in ...herpesvirus 1 LATs encode an inhibitor of cyclin (47a), no evidence ... See full document
9
The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... LAT promoter. Hyperacetylation is a prop- erty associated with a number of cellular transcriptional en- hancers (18), and it is important to note that enhancer activi- ties have previously been ... See full document
11
Regions of the Herpes Simplex Virus Type 1 Latency-Associated Transcript That Protect Cells from Apoptosis In Vitro and Protect Neuronal Cells In Vivo
... Our p⌬BstE plasmid, which does not have the splice donor junction sequence that is required to produce a 2.0-kb LAT stable intron, was unable to protect cells from apoptosis. Therefore, it is possible that the ability to ... See full document
13
Mutations in the 5' end of the herpes simplex virus type 2 latency-associated transcript (LAT) promoter affect LAT expression in vivo but not the rate of spontaneous reactivation of genital herpes.
... Of further relevance to these issues are the recent data of Garber et al. (9a) indicating that LAT-deleted HSV-1 ex- pressed lytic genes in a greater number of neurons in ganglia during acute infection, implying a ... See full document
8
Detection of herpes simplex virus type 1 latency-associated transcript expression in trigeminal ganglia by in situ reverse transcriptase PCR.
... viral promoter ele- ment. Responsive elements in the LAT promoter sequence include a TATA box (2), CCAAT box homology, and recog- nition sequences for transcription factors including Sp1, AP-2, YY-1, ... See full document
5
A Novel Herpes Simplex Virus Type 1 Transcript (AL-RNA) Antisense to the 5′ End of the Latency-Associated Transcript Produces a Protein in Infected Rabbits
... dLAT2903 virus per eye, and serum was collected from individual rabbits 57 days ...which latency had been well ...(lanes 1, 2, and 3) recognized a band corre- sponding in mobility to the AL band ... See full document
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Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcripts.
... Heights, Ill.)–20 m l of 4 mM acetyl coenzyme A and 0.25 M Tris-Cl (pH 7.4) to make a volume of 150 m l. The mixtures were incubated at 37 8 C for 1 h. Reactions were stopped by extraction with 1 ml of cold ... See full document
8
Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... The 2-kb LAT RNA interacts with ribosomal proteins and splicing factors in vivo. Our studies indicate that LAT associ- ates strongly with members of the translational complex in the cytoplasm (Fig. 3 and 4). ... See full document
11
Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... constitutive promoter (cytomegalovirus [CMV]) and was used to examine the effect of expression of the ...CMV promoter. Following infection with wild-type HSV-1, no significant difference in ... See full document
10
The nucleotide sequence, 5' end, promoter domain, and kinetics of expression of the gene encoding the herpes simplex virus type 2 latency-associated transcript.
... The 5619 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The sequence of the herpes simplex virus type 2 HSV-2 latency-associated transcript LAT region resembles that o[r] ... See full document
5
Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... proteins herpes simplex virus (HSV) uses for attachment/en- ...Interestingly, latency-associated transcript (LAT), the only viral gene consistently expressed during neuronal ... See full document
11
cis-acting elements involved in transcriptional regulation of the herpes simplex virus type 1 latency-associated promoter 1 (LAP1) in vitro and in vivo.
... during latency: (i) KOS/29, a virus with a deletion of LAP1 at both loci, does not express LAT during latency (6, 10, 11, 13); (ii) variant 1704, which is similar to KOS/29 but retains some ... See full document
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Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... allowing virus direct access to the nerves innervating the ...One type had a straight morphology (CGRP ⫹ long; ...second type had a short unbranched morphology (CGRP ⫹ short; ...of latency ... See full document
15
The latency-associated transcript gene of herpes simplex virus type 1 (HSV-1) is required for efficient in vivo spontaneous reactivation of HSV-1 from latency.
... In both experiments, the decreased spontaneous reactivation rate of the LAT deletion mutant compared with the parental or rescued virus was statistically significant McKrae versus dLAT29[r] ... See full document
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