[PDF] Top 20 Design, Development and Optimization of S (-) Atenolol Floating Sustained Release Matrix Tablets Using Surface Response Methodology

... factorial design, and the sustained release polymer concentration was considered to have a significant effect on the release from the HPMC matrices, as increase or decrease in polymer ... See full document

... in sustained release drug delivery ...to release a drug at a predetermined rate by maintaining a constant drug level for a specific period of time with minimum side ...of sustained ... See full document

... The tablets were prepared by directly compressing the mass at an average weight of 600 mg on a 10 station Lab Press compression machine (Cip machineries ...HCl sustained release matrix ... See full document

... formulating sustained release dosage ...A sustained-release (SR) formulation that would maintain plasma levels of the drug for 10 to 16 hours might be sufficient for once- daily dosing of ... See full document

... for optimization of multiple responses 24 ...like Design Expert, numerical optimization is used in order to find the specific point that maximizes the global desirability ...the Design Expert ... See full document

... drug release in stomach that will reduce the possible gastro irritant effects of the ...conventional optimization process, a single independent variable is varied while all others are kept constant at a ... See full document

... Floating matrix tablets of metformin hydrochloride were developed and evaluated for increase bioavailability by increasing gastric residence time and sustained release of drug on the ... See full document

... technique is a very simple approach of drug delivery systems that proved rational demand in the pharmaceutical arena as its ease, compliance, faster production, avoid hydrolytic or oxidative reactions occurred during ... See full document

... factorial design and response surface methodology to optimize and prepare fast disintegrating tablets of Itopride hydrochloride ...(ITOHCl). Tablets were prepared by direct ... See full document

... A response surface model central composite design with 2 independent variables at 3 different levels was used to study the effects on the dependent ...dispersible tablets were evaluated for ... See full document

... to design sustained release matrix tablets of venlafaxine hydrochloride using ion exchange resin with the incorporation of hydrophilic and hydrophobic polymer ...composite ... See full document

... the response variables are fitted to a quadratic model and regression analysis was preformed to obtain the quantitative relationships between the dependent ...D-optimal design with a polynomial quadratic ... See full document

... If the drug forms greater part of the tablet, any variation in the tablet weight obviously indicates a variation in the active ingredient this test resembles weight uniformity test. 20 Tablets were selected at ... See full document

... Okra mucilage was extracted from the fruits of Abelmoschus esclentus using organic solvent Acetone. The fruits of Abelmoschus esculentus were sliced into small pieces and soaked in 1000ml distilled water. It was ... See full document

... deliver atenolol and simvastatin for dyslipidemia and hypertension as a concomitant drug ...hand, atenolol has poor absorption in lower gastrointestinal tract, short half-life and simvastatin has poor ... See full document

... the release may follow diffusion ...semi-solid matrix or sodium bicarbonate that forms gas bubbles on reaction with dissolution medium which creates porous system that allows the drug diffuses through the ... See full document

... urea, starch acetate, lactose and sodium bicarbonate were thoroughly mixed in a dry mortar by following geometric dilution technique. Beeswax was melted in a dry beaker and the blend of the above mentioned ingredients ... See full document

... In-vitro dissolution study was performed by using USP dissolution test apparatus (Apparatus 1, Basket type) at 100 rpm for 12 h in 0.1 N HCl (900 ml). At the end of different time period 10 ml of the sample were ... See full document

... of matrix tablet ...as sustained controlled release devices for the delivery of water soluble and water insoluble ...drug release from matrices ...controlled release due to their ... See full document

... Monolayer tablets, Batches X1 and X2 were prepared using 1:1 and ...concave tablets showed accept- able crushing strength (>6 kp) and friability ...drug release was slower at later time ... See full document