[PDF] Top 20 Effects of Linked Selective Sweeps on Demographic Inference and Model Selection
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Effects of Linked Selective Sweeps on Demographic Inference and Model Selection
... of selective sweeps may be sufficient to skew patterns of diversity ...closely linked to a sweep (c/s distance of ...recent sweeps (again assuming s = ...positive selection may be quite ... See full document
33
Allele Frequency Distribution Under Recurrent Selective Sweeps
... opposing effects of back- ground selection on the frequency spectrum under the recurrent sweep ...background selection may further skew the frequency spectrum in the di- rection of negative Tajima’s ... See full document
12
Selective Sweeps
... the inference of selective sweeps described above, we have assumed that the demographic history of a population is not confounded by forms of weak selection that concern the whole ... See full document
9
Soft Shoulders Ahead: Spurious Signatures of Soft and Partial Selective Sweeps Result from Linked Hard Sweeps
... hard-sweep model of adaptation in which a de novo beneficial mutation arises and rapidly fixes in a ...their selection coefficient changes to become ...soft sweeps in genomic polymorphism ...regions ... See full document
31
A survey of methods and tools to detect recent and strong positive selection
... Positive selection occurs when an allele is favored by natural ...neighboring linked variation diminishes, creating so-called selective ...positive selection in genomes is achieved by ... See full document
17
Computational Inference Methods for Selective Sweeps Arising in Acute HIV Infection
... a selective sweep. A range of inference methods exist to analyze selective sweeps ...these inference methods assume models that do not fit the specific biology of acute HIV ...the ... See full document
26
Detecting positive selection in the genome
... 1. Selective sweeps and background ...it linked neutral ...Hard/classic sweeps - the most well-studied model of ...it sweeps, the adaptive allele carries with it a portion of the ... See full document
10
Selective Sweeps in Multilocus Models of Quantitative Traits
... on linked neutral ...two-allele model but we also provide results for diallelic models with up to eight ...two-locus model, and there is no dominance or epistasis of effects on the trait, the ... See full document
23
Patterns of Neutral Diversity Under General Models of Selective Sweeps
... general model of linked selection, rather than focusing on a limited number of specific ...that selection forces different numbers of lineages to coalesce [parameterized by nf(q)] as a function ... See full document
22
The relation between recombination rate and patterns of molecular evolution and variation in Drosophila melanogaster
... (selective sweeps or BGS) is most important in causing the patterns observed in low recombination genomes or genomic regions (Stephan ...“hard” selective sweep (in which a single newly arisen ... See full document
19
Refining the Use of Linkage Disequilibrium as a Robust Signature of Selective Sweeps
... LD-based selection statistics rather than to search for selection signatures as ...possible selection candidate based on population differentiation, possibly related to adaptation of the skin in ... See full document
41
Detection of selective sweeps in structured populations : a comparison of recent methods
... Figure Legends Figure 1: Results for the island model: a trace of the allele frequency of the selected variant in the selected population, Y, and in a neutral population, Z with migratio[r] ... See full document
30
Assessing reproducibility and the effects of demographic variables on the normal macular layers using the Spectralis SD-OCT
... restricted selection of Pakistani adults without high myopia, as such our findings may not be broadly generalizable, as macular layer thick- nesses are known to be influenced by different levels of ...the ... See full document
8
Detecting selective sweeps in naturally occurring Escherichia coli.
... Under this evolutionary scenario the polymorphism to divergence ratio will be high (HUDSON et al. A neutral locus will fall somewhere in between these two extremes. The descript[r] ... See full document
11
Limited Evidence for Classic Selective Sweeps in African Populations
... As an alternative approach to identifying important signals of selection, we searched for biological functions overrepre- sented in the tail of genomic window distributions for the iHS and XP-EHH. Motivated by the ... See full document
111
Detecting Bottlenecks and Selective Sweeps From DNA Sequence Polymorphism
... bottleneck model, it may provide an efficient way to method is an open question that goes beyond the scope maximize the likelihood with respect to T and ...nite-site model (and DNA sequence data) is ... See full document
7
Valid Post-Selection Inference
... post-selection inference as they transpire from the work of Leeb and P¨ otscher cited above (Section ...valid inference in “wrong models” (Section ... See full document
169
Bayesian inference and model selection for partially observed stochastic epidemics
... a model where a common clearance rate is assumed for the common serotypes and a model for which we set δ = ...full model estimates for common serotypes but less associated ...small effects on ... See full document
275
The effect of local variation in malaria transmission on the prevalence of sulfadoxine–pyrimethamine resistant haplotypes and selective sweep characteristics in Malawi
... Background: Persistence of sulfadoxine–pyrimethamine (SP) resistance has been described in an urban setting in Malawi where malaria transmission is relatively low. Higher malaria transmission is associated with greater ... See full document
7
A Microsatellite-Based Multilocus Screen for the Identification of Local Selective Sweeps
... captures demographic history of the populations as well as variation in microsatellite muta- tion among ...recent selective sweep differ from the re- mainder of the genome, they are expected to fall outside ... See full document
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