[PDF] Top 20 FORMULATION AND EVALUATION OF CONTROLLED RELEASE FLOATING MATRIX TABLETS OF THEOPHYLLINE

... for Theophylline was performed using ...value. Theophylline and the meltable binders, Swellable polymers selected for this investigation were found to be compatible and it was confirmed by FT-IR ...for ... See full document

... F-6 formulation showed that there was no interaction between the drug and the ...vitro release studies were performed using Disso-2000 (paddle method) in 900 ml of pH ...drug release was ... See full document

... The shorter disintegration time of remaining six formulations was due to the presence of lactose because, Lactose, by its water-soluble and hydrophilic nature, facilitates gel formation and shortens the penetration time ... See full document

... developed formulation showed promise to be bioequivalent to the marketed product ...developed formulation was found to be ...prepared Theophylline controlled release matrix ... See full document

... and release from the dosage form retained in the stomach fluids occur at the pH of the stomach under fairly controlled ...conditions. Floating systems are one of the important categories of drug ... See full document

... Conventional controlled release dosage forms have a density greater than that of gastric contents, thus these dosage forms sink to the bottom of the stomach once ...oral controlled drug systems (DDS) ... See full document

... The main function of stomach is to store food temporarily grind it and then release it gradually into the duodenum. The stomach is the important site of enzyme production. Compare to small intestine the absorption ... See full document

... vitro release study performed in ...the release of drug was retarded with the proportional increase of the polymer ...hydrophilic matrix tablets of Class III drug come into contact with the ... See full document

... retention floating drug delivery is of particular interest, for drugs which, act locally in the stomach, primarily absorbed in the stomach or upper intestine, poorly soluble at alkaline pH, have a narrow window of ... See full document

... extended release of drug were originally developed to reduce or eliminate unwanted effects such as gastrointestinal disturbances, nausea, and vomiting; the short half life of the drug also indicates the need for ... See full document

... the matrix tablets was determined according to in-house standards and it meets the requirements if the amount of the active ingredient in each of the 3 tested tablets lies within the range of 90% to ... See full document

... USP- type II dissolution apparatus (paddle type) was used for the dissolution study of prepared controlled release floating tablets. The temperature of dissolution flask was maintained at 37± ... See full document

... Immediate Release Layer. Table 3 illustrates the composition of Floating Matrix ...of tablets of all formulations. The total Weight of each formulation was maintained constant ; the ... See full document

... Method of Preparation of Dry Powder of Okra gum The matured fruits were collected, washed, dried using tray dryer at 370 C for 24 h, later the dried fruits crushed and soaked in water and heated up to 800-900 0 C for ... See full document

... drug release from the controlled release ...drug release data to the higuchi equation indicates that the drug release mechanism from these tablets was diffusion ...hydrophilic ... See full document

... Gabapentin is an anti-epileptic medication, also called an anticonvulsant. It affects chemicals and nerves in the body that are involved in the cause of seizures and some types of pain. It has been proved to be ... See full document

... Twenty tablets of each type of formulation are weighed and crushed in mortar and powder equivalent to 100 mg of cephalexin is weighed and dissolved in 100 ml of ... See full document

... the tablets are given in table 5. All the tablets of different batches complied with the official requirements of weight variation as their weight variation passes the ...the tablets ranged from ... See full document

... oral controlled-release drug delivery system is not just to sustain the drug release but also to prolong the presence of the dosage form within the gastrointestinal tract (GIT) until all the drug is ... See full document

... control release tablets are prepared by using excipients magnesium stearate, micro crystalline cellulose, lactose and polymers HPMC K-100M, HPMC E-5M ethyl cellulose, and Eudragit in different ratios ... See full document