[PDF] Top 20 Gene based analysis of rare and common variants to determine association with blood pressure
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Gene based analysis of rare and common variants to determine association with blood pressure
... JB would like to acknowledge Discovery Grant funding from the Natural Sciences and Engineering Research Council of Canada (NSERC) (grant number 293295-2009) and Canadian Institutes of Health Research (CIHR) (grant number ... See full document
5
Evaluation of gene based association tests for analyzing rare variants using Genetic Analysis Workshop 18 data
... pooled association tests for rare variants and assess the impact of different gene annotation methods and binning strategies on the analyses of rare variants under Genetic ... See full document
6
Powerful Genetic Association Analysis for Common or Rare Variants with High-Dimensional Structured Traits
... is based on apply- ing classical dimension-reduction methods, ...component analysis (Klei et al. 2008) and canonical correla- tion analysis (Ferreira and Purcell 2009), to collapse multiple traits ... See full document
12
Association tests for rare and common variants based on genotypic and phenotypic measures of similarity between individuals
... Genome-wide association studies have helped us identify thousands of common variants associated with several widespread complex ...these variants account for only a small fraction of ... See full document
8
A rapid method for combined analysis of common and rare variants at the level of a region, gene, or pathway
... becomes common. Thus, one may expect that, on average, rare variants will be more likely to be associated with deleterious ...that rare variants will be more likely to show ... See full document
9
Comparison of multilevel modeling and the family based association test for identifying genetic variants associated with systolic and diastolic blood pressure using Genetic Analysis Workshop 18 simulated data
... the association between can- didate genes and weight and body mass index based on Framingham longitudinal family data, using families as the highest level in the ... See full document
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Rare Variant, Gene-Based Association Study of Hereditary Melanoma Using Whole-Exome Sequencing
... of rare disease-causing variants is just ...linkage analysis provided a robust method to leverage recombination for positional ...relatively common endpoints, linkage has been largely ... See full document
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Enrichment analysis of genetic association in genes and pathways by aggregating signals from both rare and common variants
... enrichment analysis on top of gene-based collapsing methods for combining association signals across multiple ...of rare variants, with two methods for gene set enrichment ... See full document
5
Disease risk prediction with rare and common variants
... of rare variants on global disease risk prediction, we consider prediction models built using an SVM ...regression- based methods, the SVM is particularly useful in classify- ing high-dimensional ... See full document
5
Rare variant analysis of blood pressure phenotypes in the Genetic Analysis Workshop 18 whole genome sequencing data using sequence kernel association test
... all variants influence the trait in the same direction and with the same magnitude of effect (after incorporating known weights), their power is reduced if certain var- iants confer increased risk while others are ... See full document
6
Genetic association analysis based on a joint model of gene expression and blood pressure
... identified variants, as a consequence of the low power; however, it allows a more reliable comparison of the different methods without disentangling the effects when accounting for the family ...that rare ... See full document
6
A pathway based association analysis model using common and rare variants
... either rare or common variant effects of each pathway using a collapsing meth- ods (described in more detail later), where a threshold of 1% for the minor allele frequency was used to divide rare and ... See full document
5
Pathway based analysis of rare and common variants to test for association with blood pressure
... JB would like to acknowledge Discovery Grant funding from the Natural Sciences and Engineering Research Council of Canada (NSERC) (grant number 293295-2009) and Canadian Institutes of Health Research (CIHR) (grant number ... See full document
5
Patient complexity and genotype-phenotype correlations in biliary atresia: a cross-sectional analysis
... control association tests, including 89 patients ...genome-wide gene-based association test on common genetic variants (CV) and rare copy-number-variants (CNVs) ... See full document
9
Addition of multiple rare SNPs to known common variants improves the association between disease and gene in the Genetic Analysis Workshop 17 data
... each common variant in each gene from a logistic regression model; (2) shuffle the common SNPs across the genome to generate a per- muted data set; (3) calculate the coefficient from a logis- tic ... See full document
5
Capability of common SNPs to tag rare variants
... Genetic Analysis Workshop 17 (GAW17) data set, which is composed of 697 individuals in this ...considered rare SNPs with a minor allele fre- quency (MAF) less than ...are common SNPs with MAF > ... See full document
5
Application of family based tests of association for rare variants to pathways
... handle rare variants. Because statistical tests of individual rare variants lack power and multiple testing penalties quickly become unwieldy because of the preponderance of rare ... See full document
5
Association Analysis of the Common Genetic Variants of HNF4A Gene with Type 2 Diabetes Mellitus Risk
... corresponding gene was shown to be linked to T2DM in several ...the association between HNF4A genetic variants (rs1884613 and rs1884614) and T2DM risk in a group of Iranian ...HNF4A common ... See full document
7
Whole exome sequencing implicates eye development, the unfolded protein response and plasma membrane homeostasis in primary open angle glaucoma
... intraocular pressure (IOP); however, this concept does not capture the full spectrum of the ...complex gene-environment interactions which drive the ... See full document
18
Population structure analysis using rare and common functional variants
... explore rare versus common variants (using the same ...components analysis and demonstrated that the number of PCs required to account for population struc- ture varied by the MAF of ...used ... See full document
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