[PDF] Top 20 Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
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Interactions between Herpesvirus Entry Mediator (TNFRSF14) and Latency-Associated Transcript during Herpes Simplex Virus 1 Latency
... Herpesvirus entry mediator (HVEM) is one of several cell surface proteins herpes simplex virus (HSV) uses for attachment/en- ...Interestingly, latency-associated ... See full document
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Herpes Simplex Virus 1 Latency and the Kinetics of Reactivation Are Regulated by a Complex Network of Interactions between the Herpesvirus Entry Mediator, Its Ligands (gD, BTLA, LIGHT, and CD160), and the Latency-Associated Transcript
... reduces latency and increases time to reactivation, the absence of BTLA, LIGHT, or CD160 reduces the level of latency but decreases the time to ...gD transcript was higher than that of gC ... See full document
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Coregulatory Interactions among CD8α Dendritic Cells, the Latency-Associated Transcript, and Programmed Death 1 Contribute to Higher Levels of Herpes Simplex Virus 1 Latency
... of virus- induced blindness (8, 9, 40). Because of the problems associated with recurrent ocular infection, reducing the establishment of la- FIG 7 PD-1 expression was not altered in the presence of ... See full document
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The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... of latency must lie downstream of the BstEII ...genome during the establishment phase of ...region between the BstEII site at bp 120092 and the ApaI site at bp 121568 is necessary and may be ... See full document
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The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... On cellular chromosomes, specific classes of chromatin bound- aries act to separate heterochromatic domains from euchro- matic domains, and some types of boundaries have enhancer- blocking (insulator) activities (23, ... See full document
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In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... 1994 During herpes simplex virus latency, transcripts accumulate from a single transcription unit of the viral ...these latency-associated transcripts (LAT) has been ... See full document
7
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... efficiencies between any of the mutant or genomically wild-type ...or between results obtained in the replicate experiments, compared to the data shown in ...and between experiments (data not shown). ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... pseudorabies virus, and bovine herpesvirus did not demonstrate significant homology, all exhibited a high abun- dance of the dinucleotide 5 9 CpG3 9 ...LAT transcript, is GC rich (6, 12), the 348-bp ... See full document
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CTCF-Dependent Chromatin Boundary Element between the Latency-Associated Transcript and ICP0 Promoters in the Herpes Simplex Virus Type 1 Genome
... the latency specific LAT gene away from the neigh- boring, silenced lytic specific ...separate during different phases of the infection cycle and to localize the effects of enhancer or si- lencer elements ... See full document
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Transcription of the Herpes Simplex Virus Latency-Associated Transcript Promotes the Formation of Facultative Heterochromatin on Lytic Promoters
... promoters during la- tency ...The virus used by Wang et ...deletion virus, KOS ...ing latency. These results provide the strongest connection to date between LAT transcription and ... See full document
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Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... differences between HSV-1 and HSV-2, the fact that different portions of the LAT were used in these two transgenic mice, or that the HSV-1 transgenic mouse used the CMV promoter, which may confer a ... See full document
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Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... Scarification may therefore promote infection of a different set of neurons relative to human corneal infections. It was also surprising to see NefH ⫹ CGRP ⫺ neurons with prominent LAT promoter activity, since these are ... See full document
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In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... of latency. New Zealand White rabbits (2 to 3 kg) were inoculated with 1 ⫻ 10 5 to 2 ⫻ 10 5 PFU of virus per eye in a suspension of 25 l MEM with 5% ...prevent virus loss ... See full document
10
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... Rabbit model of ocular HSV-1 infection, latency, and spontaneous reactiva- tion. Rabbits were bilaterally infected without scarification or anesthesia by placing 2 ⫻ 10 5 PFU of HSV-1 into the ... See full document
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The herpes simplex virus latency-associated transcript is spliced during the latent phase of infection.
... portion of spliced LAT seen in mouse sensory nerve ganglia latently infected with the McKrae, 17syn+, and Maclntyre strains of HSV-1 with that from mice and rabbits infected with the KOS[r] ... See full document
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Physical characterization of the herpes simplex virus latency-associated transcript in neurons.
... RNA transfer (Northern) blot analysis was used to perform the physical characterization of the transcript expressed in murine sensory nerve ganglia latently infected with herpes simplex [r] ... See full document
9
Two herpes simplex virus type 1 latency-active promoters differ in their contributions to latency-associated transcript expression during lytic and latent infections.
... production during lytic infection, thereby assist- ing the virus in establishing ...Once latency is estab- lished, LAP1 expresses LAT in order to maintain the latent state by inhibiting ICP0 protein ... See full document
10
Expression of herpes simplex virus type 2 latency-associated transcript in neurons and nonneurons.
... Latent infection of mouse dorsal root ganglion was investigated with the BamHI p fragment of HSV-2, which resulted in evidence of ganglion hybridization, and other fragments.. representi[r] ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Reduces Human Neuroblastoma Cell Proliferation
... genes transcript levels by REST showed while the expression of cell cycle controller genes like EP300, P15, RBL1 and RBL2 were increased significantly, the cell cycle promoting genes like Mapk-1 indicated ... See full document
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During latency, herpes simplex virus type 1 DNA is associated with nucleosomes in a chromatin structure.
... Latent herpes simplex virus type 1 DNA has a nucleosomal structure similar to that of cellular chromatin, as determined by micrococcal nuclease digestion.. All of the major regions, incl[r] ... See full document
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