[PDF] Top 20 Pleiotropic Model of Maintenance of Quantitative Genetic Variation at Mutation-Selection Balance
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Pleiotropic Model of Maintenance of Quantitative Genetic Variation at Mutation-Selection Balance
... high genetic variance but the apparent stabilizing selection may or may not be relatively strong, depending on other properties such as the distribution of mutation ...of mutation effects on ... See full document
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Joint Effects of Pleiotropic Selection and Stabilizing Selection on the Maintenance of Quantitative Genetic Variation at Mutation-Selection Balance
... stabilizing selection, selection is assumed to arise solely from the deviations of the metric traits from their optimum due to mutational effects ...phenotypic selection, selection directly ... See full document
14
Asexual but Not Clonal: Evolutionary Processes in Automictic Populations
... neutral genetic variation, effective population size, mutation–selection balance, selection with overdominance, the spread of bene fi cial mutations, and selection on ... See full document
17
Genetic Variation Maintained in Multilocus Models of Additive Quantitative Traits Under Stabilizing Selection
... ANY quantitative characters in natural popula- ...principle, variation can be maintained tions are apparently subject to stabilizing selec- either by mechanisms acting directly on the considered tion toward ... See full document
14
Redistribution of Gene Frequency and Changes of Genetic Variation Following a Bottleneck in Population Size
... of mutation parameters, the joint-effect model can explain data from laboratory experiments on the effect of bottlenecking on fitness and morpho- logical traits, providing further support for it as a ... See full document
18
Pleiotropic models of polygenic variation, stabilizing selection, and epistasis.
... Stabilizing selection is also observed if the polygenic system is at an equilibrium determined by a balance between selection and mutation (or migration) when both additive an[r] ... See full document
17
Mutation-Selection Balance, Dominance and the Maintenance of Sex
... truncation selection is an idealization, the basic as intralocus synergistic epistasis in contrast to the in- idea also applies to more general types of synergistic terlocus epistasis assumed in the Kondrashov ... See full document
7
A pleiotropic nonadditive model of variation in quantitative traits.
... With P element parameters, partitioning of the con- tribution to the genetic variance from different catego- ries of mutations (Table 2) shows that most of the vari- ance is co[r] ... See full document
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PLEIOTROPIC OVERDOMINANCE AND THE MAINTENANCE OF GENETIC VARIATION IN POLYGENIC CHARACTERS
... --n.. In this instance the optimum model is also providing some selection for the heterozygote. However, a parabolic distribution at the individual loci does not i[r] ... See full document
10
Influence of Dominance, Leptokurtosis and Pleiotropy of Deleterious Mutations on Quantitative Genetic Variation at Mutation-Selection Balance
... on genetic variance (Wang et ...of genetic variation (Kimura 1965; Lande that, in the absence of saturation and feedback or other 1976; Turelli 1984; Barton 1990; Keightley and nonlinearities, traits ... See full document
14
Multivariate mutation-selection balance with constrained pleiotropic effects.
... In terms of quantitative genetic theory this means that the possi- ble pleiotropic effects of quantitative genetic variation are most often not changed by mutations at [r] ... See full document
12
The quantitative genetic consequences of pleiotropy under stabilizing and directional selection.
... If genetic variation is maintained by pleiotropic alleles in very low frequencies as in the house-of-cards model, then directional selection would tend to in- crease [r] ... See full document
7
Pleiotropic models of quantitative variation.
... HILL, 1989 Quantitative genetic variability maintained by mutation-selection balance: sampling variation and response to subsequent directional selection. KACSER, 1987 Dominance,[r] ... See full document
10
Linkage and the maintenance of heritable variation by mutation-selection balance.
... two-locus models. Cambridge University Press. FELDMAN, 1970 Linkage and selection: two locus symmetric viability model. HILL, 1988 Quantitative genetic variability maintained b[r] ... See full document
10
Dynamic Mutation–Selection Balance as an Evolutionary Attractor
... dynamic balance state has important implications for patterns of molecular ...purifying selection on the structure of genealogies has suggested that Muller’s ratchet plays a crucial role in determining the ... See full document
18
THE GENETIC STRUCTURE OF NATURAL POPULATIONS OF DROSOPHILA MELANOGASTER. XVIII. CLINAL AND UNIFORM GENETIC VARIATION OVER POPULATIONS
... R States populations maintain a greater amount of genetic variability of viability that can be explained by a mutation-selection balance (MUKAI et al. T h e estimat[r] ... See full document
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EFFECTS OF RESTRICTED POPULATION SIZE AND INCREASE IN MUTATION RATE ON THE GENETIC VARIATION OF QUANTITATIVE CHARACTERS
... The effects of population size and increase in mutation rate on the mean and genetic variance of quantitative characters and the genetic load associated with these characters ha[r] ... See full document
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<p>Pleiotropic action of genetic variation in ZNF804A on brain structure: a meta-analysis of magnetic resonance imaging studies</p>
... Although there is a number of evidence to support the influence of the ZNF804A gene on the brain structure of healthy individuals and those with mental disorders, they are inconsistent. There is still a lack of ... See full document
9
Mutation-Selection Balance at a Modifier-of-Imprinting Locus
... The models predict the stable equilibrium frequencies of the mutant modifier and functionally diploid individuals in a large population in terms of up to four parameters: the m[r] ... See full document
7
Mutation-selection balance and metabolic control theory.
... Changes in activity of an enzyme will affect the immediately flanking metabolite pools more than pools more distant in the pathway (as is the case for the human inborn e[r] ... See full document
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