[PDF] Top 20 Pocket Protein p130/Rb2 Is Required for Efficient Herpes Simplex Virus Type 1 Gene Expression and Viral Replication
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Pocket Protein p130/Rb2 Is Required for Efficient Herpes Simplex Virus Type 1 Gene Expression and Viral Replication
... cycle-regulated gene promot- ers are occupied by different pocket protein-E2F complexes at various phases of the cell cycle (72, ...by pocket proteins and E2F is complex and each pocket ... See full document
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Transient Expression of Herpes Simplex Virus Type 1 ICP22 Represses Viral Promoter Activity and Complements the Replication of an ICP22 Null Virus
... to expression of ...ICP22 expression vectors but not with plasmids expressing only the 200 N-terminal amino acids of ICP22 (data not ...porter gene, which strongly argues that ICP22 does not affect ... See full document
11
Viral replication is required for induction of ocular immunopathology by herpes simplex virus.
... HSV type 1 (HSV-1) RE and HSV-1 ...d301 virus (14) contains a deletion in the ICP8 gene. This b gene product is a major viral DNA-binding protein and is ... See full document
7
Arginine-rich regions succeeding the nuclear localization region of the herpes simplex virus type 1 regulatory protein ICP27 are required for efficient nuclear localization and late gene expression.
... The herpes simplex virus type 1 (HSV-1) immediate-early protein ICP27 is an essential regulatory protein that localizes to the nuclei of infected ...were ... See full document
12
Elimination of Mitochondrial DNA Is Not Required for Herpes Simplex Virus 1 Replication
... AN1 virus infection (43) and demonstrate that UL98 can restore viral repli- cation to near wild-type levels in the absence of UL12 and ...UL12.5. Viral protein expression. Since ... See full document
10
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication.
... regulatory protein of herpes simplex virus type 1 (HSV- ...of viral gene expres- sion during the course of infection. HSV-1 gene expression is ... See full document
11
Herpes Simplex Virus type 1 lytic viral gene expression during the establishment and maintenance of latency
... whole viral genome preparation used was approximately 61 plaques per µg of DNA (data not shown), less than the 100-1000 plaques per µg of viral DNA recommended for the generation of recombinant HSV-1 ... See full document
353
The Herpes Simplex Virus Type 1 Cleavage/Packaging Protein, UL32, Is Involved in Efficient Localization of Capsids to Replication Compartments
... wild-type virus and a virus with a mutant version of cleav- age and packaging gene UL6, capsids localize exclusively to replication compartments, cells infected with the UL32 mutant ... See full document
11
Nucleolin Is Required for an Efficient Herpes Simplex Virus Type 1 Infection
... regulation, viral replication, and cellular stress re- sponses (3, ...like viral DNA replication, virus assembly, and control of intracellular trafficking (for reviews see references 22 ... See full document
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The UL14 Tegument Protein of Herpes Simplex Virus Type 1 Is Required for Efficient Nuclear Transport of the Alpha Transinducing Factor VP16 and Viral Capsids
... (lanes 1, 4, and 7) in the presence (lanes 1 and 2) or the absence (lanes 3 to 7) of ...UL42 protein (an early protein not incorporated into virions) to assay for de novo protein ... See full document
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Nucleolin Is Required for Efficient Nuclear Egress of Herpes Simplex Virus Type 1 Nucleocapsids
... multifunctional protein that exhibits broad lo- calization in nucleoli, nucleoplasm, cytoplasm, and the plasma membrane; interacts with a wide variety of cellular and viral proteins; and affects various ... See full document
12
Cellular Transcriptional Coactivator RanBP10 and Herpes Simplex Virus 1 ICP0 Interact and Synergistically Promote Viral Gene Expression and Replication
... erpes simplex virus 1 (HSV-1) has more than 80 different genes that fall into three major classes, designated immediate early (IE) or ␣ , early (E) or  , and late (L) or ␥ , which are ex- ... See full document
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ICP0 Is Required for Efficient Reactivation of Herpes Simplex Virus Type 1 from Neuronal Latency
... infectious virus in cells or tissues that contain viral genomes, whereas reactivation has been defined as the de novo production of new infectious virus from cells containing latent viral ... See full document
10
The ATM and Rad3-Related (ATR) Protein Kinase Pathway Is Activated by Herpes Simplex Virus 1 and Required for Efficient Viral Replication
... HSV-1 replication. Following HSV-1 infection (17syn ⫹ ; MOI ⫽ ...of viral genomes was significantly inhibited in the ATR-deficient cells relative to that in normal patient fibroblasts at the 8-, ... See full document
16
ICP27 Phosphorylation Site Mutants Are Defective in Herpes Simplex Virus 1 Replication and Gene Expression
... chaperone protein Hsc70 is sequestered in nuclear foci that lie at the periphery of viral replication compartments (1, ...(for virus-induced-chaperone-en- riched), also contain other ... See full document
12
Herpes Simplex Virus 1 γ134.5 Protein Inhibits STING Activation That Restricts Viral Replication
... Antibodies. Anti-Myc antibody (sc-40), ant-HSV-1 ICP0 antibody (sc-53070), and m-IgG BP- fluorescein isothiocyanate (FITC) (sc-516140) were purchased from Santa Cruz Biotechnology. Anti-Myc- horseradish peroxidase ... See full document
11
Activation of human papillomavirus type 18 gene expression by herpes simplex virus type 1 viral transactivators and a phorbol ester.
... A plasmid containing the HPV-18 noncoding region placed upstream of the chloramphenicol acetyltransferase reporter gene was cotransfected with different herpes simplex virus type 1 HSV-1[r] ... See full document
9
Gene-specific transactivation by herpes simplex virus type 1 alpha protein ICP27.
... The alpha protein ICP27 has been suggested to play an essential role in HSV-1 gene activation because viral mutants containing ts lesions in the ICP27 gene fail to accumulate gamma 2 and[r] ... See full document
10
Herpes Simplex Virus Type 1 Immediate-Early Protein ICP27 Is Required for Efficient Incorporation of ICP0 and ICP4 into Virions
... of expression, as both proteins were readily detected in the infected-cell lysates (lanes 2 and ...envelope protein gD and tegument protein ... See full document
10
Potential role for herpes simplex virus ICP8 DNA replication protein in stimulation of late gene expression.
... The patterns of viral protein synthesis at 3 or 6 h postinfection were similar in the 3 different cell lines, except that significant amounts of the mutant form of ICP8 expressed from th[r] ... See full document
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