[PDF] Top 20 Properties of the novel herpes simplex virus type 1 origin binding protein, OBPC.
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Properties of the novel herpes simplex virus type 1 origin binding protein, OBPC.
... of OBPC in this process, is a consideration of the structure of replicative inter- ...commences. OBPC may function to mediate this ...that OBPC can inhibit origin-dependent viral DNA replica- ... See full document
7
Genome Replication and Progeny Virion Production of Herpes Simplex Virus Type 1 Mutants with Temperature-Sensitive Lesions in the Origin-Binding Protein
... the virus-encoded factors essential for herpes sim- plex virus type 1 (HSV-1) DNA replication (5, 6, 9, 42) is the UL9 gene product (13), which due to its affinity for the ... See full document
6
Helicase Motif Ia Is Involved in Single-Strand DNA-Binding and Helicase Activities of the Herpes Simplex Virus Type 1 Origin-Binding Protein, UL9
... Bradford protein assay and analyzed fur- ...UL9 protein and proteinase K at a concentration of ...null virus hr94. (A) Complementation indices for wild- type (WT) and mutant UL9 ...UL9 ... See full document
12
Origin Binding Protein-Containing Protein-DNA Complex Formation at Herpes Simplex Virus Type 1 oriS: Role in oriS-Dependent DNA Replication
... termed OBPC, has also been shown to bind to oriL and oriS (2). OBPC, encoded by the ...and OBPC are translated in the same reading frame, the amino acid sequence of OBPC is identical to the ... See full document
9
Use of transdominant mutants of the origin-binding protein (UL9) of herpes simplex virus type 1 to define functional domains.
... by binding origin DNA into an inactive ...ATP binding and hydrolysis, since they contain the estab- lished ATP-binding consensus sequences (32, ...ATPase binding and/or hydrolysis ... See full document
8
DNA Binding Activity of the Herpes Simplex Virus Type 1 Origin Binding Protein, UL9, Can Be Modulated by Sequences in the N Terminus: Correlation between Transdominance and DNA Binding
... DNA binding ability with slightly reduced efficiency compared to the C ter- ...DNA binding assay as a control ...DNA binding efficiencies ...DNA binding activity ...the origin of ... See full document
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Purification of the herpes simplex virus type 1 65-kilodalton DNA-binding protein: properties of the protein and evidence of its association with the virus-encoded DNA polymerase.
... 8 Purification of the Herpes Simplex Virus Type 1 65-Kilodalton DNA-Binding Protein: Properties of the Protein and Evidence of Its Association with the Virus-Encoded DNA Polymerase MICHA[r] ... See full document
10
Herpes Simplex Virus Type 1 DNA-Packaging Protein UL17 Is Required for Efficient Binding of UL25 to Capsids
... A function of UL25 and possibly also UL17 may be to reinforce the capsid shell, stabilizing the capsid and possibly the packaging machinery at the portal during and after inser- tion of the genome into the capsid. It has ... See full document
9
Immune evasion properties of herpes simplex virus type 1 glycoprotein gC.
... influenza virus, lymphocytic choriomeningitis virus (LCMV), and human immunodefi- ciency virus, escape humoral or cellular immunity by mutating antigens that are immune targets (18, 43, ...19-kDa ... See full document
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Herpes Simplex Virus Type 1 C-Terminal Variants of the Origin Binding Protein (OBP), OBPC-1 and OBPC-2, Cooperatively Regulate Viral DNA Levels In Vitro, and OBPC-2 Affects Mortality in Mice
... Because OBPC-2 is significantly smaller than OBPC-1 and lacks the first seven N-terminal amino acids of the mapped origin DNA binding domain of OBP (1, 15, 37), we were ... See full document
13
Cathepsin B Mediates Cleavage of Herpes Simplex Virus Type 1 Origin Binding Protein (OBP) To Yield OBPC-1, and Cleavage Is Dependent upon Viral DNA Replication
... of OBPC-2 (35 kDa) is much smaller than would be predicted (64 kDa) if the first start codon of the ...the protein suggests that it was not detected by Baradaran et ...the protein ran off the gels ... See full document
8
Characterization of major recognition sequences for a herpes simplex virus type 1 origin-binding protein.
... 4096-4103 0022-538X/88/114096-08$02.00/0 Copyright C 1988, American Society for Microbiology Characterization of Major Recognition Sequences for a Herpes Simplex Virus Type 1 Origin-Bind[r] ... See full document
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Purification and characterization of UL9, the herpes simplex virus type 1 origin-binding protein.
... Two binding sites for the herpes simplex virus type 1 UL9 protein are required for efficient activity of the oriS replication origin.. Genetic analysis of temperature-sensitive mutants w[r] ... See full document
10
Herpes simplex virus type 1 origin-specific binding protein: oriS-binding properties and effects of cellular proteins.
... Incubation of infected cell extracts with the lower-affinity site II DNA as a probe resulted in the appearance of two protein-DNA complexes with mobilities identical to those of the A an[r] ... See full document
11
Phosphorylation of the Herpes Simplex Virus Type 1 Origin Binding Protein
... a protein referred to as a replication ...(i) binding to the origin of DNA replication, (ii) unwinding origin DNA, and (iii) recruiting additional proteins necessary for DNA ...simian ... See full document
10
The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for function.
... Binding of the herpes simplex virus type 1 UL9 gene product to an origin of viral DNA replication.. Nucleic Acids Res.[r] ... See full document
12
Membrane Association of VP22, a Herpes Simplex Virus Type 1 Tegument Protein
... tegument protein, VP22, is a critical structural component of the virion with potential implications for virus ...abies virus VP22 may interact with both gM and gE ...the ... See full document
11
Packaging Determinants in the UL11 Tegument Protein of Herpes Simplex Virus Type 1
... of virus-en- coded UL11 ...on virus assembly and release? Again, the large background of virions produced by untransfected cells makes this question difficult to address, but it needs to be kept in mind for ... See full document
8
Intercellular Trafficking of VP22, a Herpes Simplex Virus Type 1 Tegument Protein
... Construction of pGFP-VP22 plasmid. pGFP- VP22 was constructed by in frame ligation of BamH1-Xba1 fragment of pVP22/myc-His2 (Invitrogen, Carlsbad, CA, USA), a commercially available VP22 expression vector that contains ... See full document
5
Intracellular Trafficking of the UL11 Tegument Protein of Herpes Simplex Virus Type 1
... viral protein that is required for ...UL11 protein (top) is myristylated (wavy line) and contains the acidic cluster (AC) (residues 37 to 43, indicated by a black box) along with a cluster of three ... See full document
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