[PDF] Top 20 Statistics review 4: Sample size calculations
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Statistics review 4: Sample size calculations
... large sample size to detect such a difference in mortality with any ...this size using a cutoff for statistical significance of ...important 4% reduction in mortality, a trial of 304 patients ... See full document
7
Sample size calculations based on a difference in medians for positively skewed outcomes in health care studies
... analytical sample size formula presented (Eq. (4)) was accurate when evaluated using extensive simulation ...required sample size for situations in which two groups are compared and the ... See full document
11
Sample size and power calculations for detecting changes in malaria transmission using antibody seroconversion rate
... the sample size warranting a given power and estimation ...ple size should be made on the basis of not only statis- tical arguments, as discussed here, but also on possible sampling constraints that ... See full document
14
Sample size calculations for the design of cluster randomized trials: A summary of methodology.
... A ‘non - aggregate’ design uses the individual observations as the unit of analysis and so the regression models may be extended to account for individual covariate values such as, for example, subject gender, age, ... See full document
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Practical guide to sample size calculations: non-inferiority and equivalence trials
... Table 3: Summary of considerations in setting non-inferiority limits. The setting of a non-inferiority limit is a controversial is- sue. Regulatory guidelines exist to provide guidance on the topic [3],[4]. The ... See full document
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Are non-constant rates and non-proportional treatment effects accounted for in the design and analysis of randomised controlled trials? A review of current practice
... used sample size calculation methods to determine the number of events needed are based on the non-parametric log rank test [14, 15] which is most powerful for detecting alternative hypotheses when the ... See full document
9
Sample size calculations for crossover thorough QT studies: Non-inferiority and assay sensitivity
... A review of statistical design and analysis in thorough QT studies can be found in Patterson et ...of sample size on power for fixed covariance parameters, estimated from their own data, for a ... See full document
20
Sample size calculations for model validation in linear regression analysis
... and sample size ...and sample size procedure for the joint test of inter- cept and slope coefficients with specific recognition of the stochastic features of predictor ...and sample ... See full document
9
Bayesian average error based approach to sample size calculations for hypothesis testing
... Suppose an investigator wishes to conduct two follow-up studies to assess the safety of rosuvastatin in children. The first study is aimed at investigating if children treated with rosuvastatin (20mg dose) are at higher ... See full document
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A multivariate approach to sample size calculations for thorough QT studies
... with 4 treatment arms; placebo, moxifloxacin (positive control), and two doses of the new ...hr, 4 hr, 6 hr, 12 hr, and ...(QTcF). Sample size was planned to ensure that 40 subjects would ... See full document
23
Rasch fit statistics and sample size considerations for polytomous data
... The Hospital Anxiety and Depression Scale (HADS) [22] was originally developed for screening for psychological distress in the general medical population. The scale con- sists of 7 items forming a Depression subscale ... See full document
11
Discrimination-based sample size calculations for multivariable prognostic models for time-to-event data
... 2010 review, Mallett et ...a review of publi- cations which presented or validated prognostic mod- els for patients with operable breast cancer, and found that of the 61 papers reviewed, 79 % were ... See full document
12
Sample Size Calculations for Population Size Estimation Studies Using Multiplier Methods With Respondent Driven Sampling Surveys
... to 4 in our sample size calculations, but it is possible that a higher value would be more ...population size estimation study of 9 communities in Zimbabwe, we found evidence of high ... See full document
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Sample Size Calculations for Population Size Estimation Studies Using Multiplier Methods With Respondent Driven Sampling Surveys
... Population size estimates (PSE) for those most at risk for human immunodeficiency virus infection are crucial to make epidemic projections, allocate funding, and monitor coverage of prevention and care programs ... See full document
7
Test for Homogeneity of Odds Ratios Using U Statistics
... of Statistics A few procedures have been developed for testing the homogeneity of odds ...asymptotic statistics were derived for “large-stratum” settings, where the sample size is large, and ... See full document
14
Practical guide to sample size calculations: superiority trials
... Each component of the sample size calculation can be entered into the app. For ease, the app provides a list of suggested entries you can select from. For example (Figure 4), if you select ... See full document
10
Sample size calculations for skewed distributions
... Sample size calculations estimate the required number of patients to meet a study ’ s ...practice. Sample size calculations are often based on normal approximation, such as those ... See full document
9
Practical guide to sample size calculations: an introduction
... 3. Analysis It is important to establish whether the same analysis was con- ducted and same summary statistics used. We are often faced with little information to inform the design of a new clinical trial; ... See full document
18
Sample size calculations in pediatric clinical trials conducted in an ICU: a systematic review
... the sample size calculation (nuisance parameters, ...systematic review to investigate the impact of misspecification of nuisance parameters in pediatric randomized controlled trials conducted in ... See full document
9
Current practice in methodology and reporting of the sample size calculation in randomised trials of hip and knee osteoarthritis: a protocol for a systematic review
... chosen sample size and justification, parameters used to calculate the sample size (including treatment effect in control arm, level of variability in primary outcome, loss to follow-up ...the ... See full document
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