[PDF] Top 20 In vitro binding of human T-cell leukemia virus rex proteins to the rex-response element of viral transcripts.
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In vitro binding of human T-cell leukemia virus rex proteins to the rex-response element of viral transcripts.
... To analyze the binding capacity of rex protein to radiolabeled RRX transcripts, we used the Northwestern blotting assay, which was previously used successfully to demonstrate specific bi[r] ... See full document
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The human T-cell leukemia virus type 1 Rex regulatory protein exhibits an impaired functionality in human lymphoblastoid Jurkat T cells.
... that human Jurkat T cells were not providing a permissive environment to Rex activity but were supporting Rev function should be discussed with regard to the pathogen- esis of HTLV-1 and ...sustained ... See full document
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Inhibition of human T-cell leukemia virus type 2 Rex function by truncated forms of Rex encoded in alternatively spliced mRNAs.
... the Rex/RXRE regulatory pathway of HTLV, the HIV-1 Rev protein activates the expression of unspliced and singly spliced HIV-1 mRNAs through interaction with an RNA target termed the Rev-responsive element ... See full document
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Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding.
... with Rex/Rev mutants revealed that the mu- tants could be classified into two types (32, 42, 43, 48, ...simplex virus (69), and GAL4 protein of yeasts (24), and it has been called ‘‘squelching’’ ...in ... See full document
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Human T-cell leukemia virus type 2 Rex inhibits pre-mRNA splicing in vitro at an early stage of spliceosome formation.
... Several human retroviruses have evolved similar strategies for viral gene ...Env proteins are expressed from unspliced gag or singly spliced env ...in human T-cell ... See full document
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Site-Specific Phosphorylation Regulates Human T-Cell Leukemia Virus Type 2 Rex Function In Vivo
... Human T-cell leukemia virus type 2 (HTLV-2) Rex is a transacting regulatory protein required for efficient cytoplasmic expression of the unspliced and incompletely spliced ... See full document
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Phosphorylation of Two Serine Residues Regulates Human T-Cell Leukemia Virus Type 2 Rex Function
... the human T-cell leukemia virus (HTLV) Rex phosphoprotein is to increase the level of the viral structural and enzymatic gene products expressed from the incompletely ... See full document
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High-resolution mapping of the human T-cell leukemia virus type 1 Rex-binding element by in vitro selection.
... influence Rex binding do not occur exclusively within the core; for example, modifi- cation of C-172 with hydrazine resulted in enhanced interac- tions with Rex ...contact Rex but might aid in ... See full document
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Involvement of Human CRM1 (Exportin 1) in the Export and Multimerization of the Rex Protein of Human T-Cell Leukemia Virus Type 1
... The Rex protein of human T-cell leukemia virus type 1 acts posttranscriptionally to induce the cytoplasmic expression of incompletely spliced or unspliced mRNAs encoding ... See full document
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Phosphorylation regulates human T cell leukemia virus type 1 Rex function
... phosphorylated Rex-1, but also assign phosphorylation to site-specific residues by peptide sequencing using tandem mass ...that Rex-1 is phosphorylated predominantly on serine and threonine ...for ... See full document
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Inhibition of Human Immunodeficiency Virus Rev and Human T-Cell Leukemia Virus Rex Function, but Not Mason-Pfizer Monkey Virus Constitutive Transport Element Activity, by a Mutant Human Nucleoporin Targeted to Crm1
... for binding to the RRE RNA target (28, ...cellular proteins bearing leucine-rich NESs, as well as for the nuclear export of 5S rRNA and several U snRNAs (7, 13, 17, 33, ... See full document
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Human T-cell leukemia virus type II nucleotide sequences between env and the last exon of tax/rex are not required for viral replication or cellular transformation.
... the virus life cycle for the sequences between env and the last exon of ...in cell culture but plays a critical role in pathogenicity and the development of AIDS when assayed in monkeys ...functional ... See full document
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Human T-Cell Leukemia Virus Type 1 Expressing Nonoverlapping Tax and Rex Genes Replicates and Immortalizes Primary Human T Lymphocytes but Fails To Replicate and Persist In Vivo
... and Rex was proposed to be important for the virus to evade immune recognition in ...other transcripts that are unaffected by p30, such as gag/pol ...for viral persistence in an ... See full document
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Different sites of interaction for Rev, Tev, and Rex proteins within the Rev-responsive element of human immunodeficiency virus type 1.
... Both human immunodeficiency virus HIV and human T-cell leukemia viruses HTLV regulate the expression of their structural proteins by specific viral factors called Rev and Rex, respective[r] ... See full document
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Human T-Cell Leukemia Virus Type 2 Rex Protein Increases Stability and Promotes Nuclear to Cytoplasmic Transport of gag/pol and env RNAs
... that Rex increases the full-length unspliced viral RNA in the cytoplasm but has a less dramatic effect on the singly spliced env ...Thus, Rex functions to promote nu- clear-cytoplasmic transport of ... See full document
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Mutational analysis of the human T-cell leukemia virus type I trans-acting rex gene product.
... The phenotype of the various mutant proteins was tested on the homologous HTLV-I rex response element sequence and the heterologous human immunodeficiency virus type 1 HIV-1 rev response[r] ... See full document
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Human T-Cell Leukemia Virus Type 2 Rex Carboxy Terminus Is an Inhibitory/Stability Domain That Regulates Rex Functional Activity and Viral Replication
... active Rex-2 mutants, A157D and S158Term, led to increased pro- duction of p19 Gag as measured in the culture supernatant, ultimately increasing HTLV-2 infectious spread and HTLV-2- mediated cellular proliferation ... See full document
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Functional analysis of human T-cell leukemia virus type I rex-response element: direct RNA binding of Rex protein correlates with in vivo activity.
... The correlation between our in vivo results and the direct binding of Rex protein to mutant and wild-type RxRE sequences supports both the existence of the predicted secondary structure [r] ... See full document
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Nuclear Export and Expression of Human T-Cell Leukemia Virus Type 1 tax/rex mRNA Are RxRE/Rex Dependent
... for binding to and transactivating the viral long terminal repeat (LTR) (15, 23, 26, ...30). Rex has at least three domains that are important for its functions: an arginine-rich re- gion important ... See full document
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Rev and Rex proteins of human complex retroviruses function with the MMTV Rem responsive element
... pHMRluc vector indicate that the regulatory proteins primarily lacked effects on nuclear RNA export and RNA stability (Figure 7). Since effects on cytosolic RNA levels and Gag production were clearly demonstrable ... See full document
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