Quantitative Trait Loci (QTL) mapping
Statistical Methods for Latent Class Quantitative Trait Loci Mapping
... two classes. As in the previous case study, the percentage of variance explained by lcQTL is greatly increased over standard methods when two classes are identified for all of the traits (see Table S3 in File S1). Figure ...
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Quantitative Trait Loci Mapping of the Mouse Plasma Proteome (pQTL)
... 2011). An alterative approach for future studies might be targeted proteomics (Gstaiger and Aebersold 2009). This technique permits simultaneous analysis of a prespecified set of proteins and is currently an area of ...
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A Novel Targeted Learning Method for Quantitative Trait Loci Mapping
... phenotypic trait value Y given the vector M in stage one is not targeted toward the parameter of interest; its bias–variance trade-off is for the overall ...
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Mapping Quantitative Trait Loci for Longitudinal Traits in Line Crosses
... a quantitative trait is con- trolled by the segregation of many genes, each with a small ...a quantitative trait is the theory that the genetic variances of many quantitative traits are ...
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A Penalized Likelihood Method for Mapping Epistatic Quantitative Trait Loci With One-Dimensional Genome Searches
... identifying loci of high inter- this ...interval mapping (IM; Lander and Botstein 1989) from the different ...the trait on the This article presents a one-dimensional search ap- QTL and its QTL by ...
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Mapping Quantitative Trait Loci Using Generalized Estimating Equations
... then repeated until parameter estimates converge. GEE framework: One of the strengths of the approach is Note that this gives estimates of all parameters, includ- that we need not specify a full probability model for ing ...
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QTL Positioning of Thousand Wheat Grain Weight in Qaidam Basin
... a mapping population used by International Triticeae Mapping Initiative to construct a wheat genetic linkage ...marker loci on each chromosome, achieving a saturated ...wheat quantitative ...
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Joint Mapping of Quantitative Trait Loci for Multiple Binary Characters
... QTL mapping by improving ducted via either the expectation-maximization (EM) the statistical power of QTL detection and increasing algorithm (Dempster et ...the mapping population are genetically problem ...
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Quantitative Trait Loci (QTL) Mapping With Longitudinal Traits
... interval mapping method in our model inference. In interval mapping, it may produce biased estimation if multiple QTLs are linked to the marker or the interval between the ...interval mapping (Zeng, ...
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Mapping Quantitative Trait Loci by Genotyping Haploid Tissues
... out- mapping (CIM), can effectively reduce the influence of crossed progeny (similarly, the selfed progeny is de- linked QTL on parameter estimation by controlling the noted by the uppercase superscript S; see ...
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Mapping Quantitative Trait Loci for Anxiety in Chromosome Substitution Strains of Mice
... CSS-6 and B6, two QTL affecting OFA were detected: 4, and 15, exert a large effect on emotionality (Flint one of LOD 3.7 between D6Mit138 and D6Mit274 at et al. 1995; Gershenfeld et al. 1997; Talbot et al. 1999; 4.9 cM ...
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Assessing the Significance of Quantitative Trait Loci in Replicable Mapping Populations
... which trait observations are reassigned without replacement among the ...QTL mapping in populations derived from crosses among RI lines, failing to adequately take complex relationships among individuals ...
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Mapping Quantitative Trait Loci in Outbred Half-sib Populations
... in mapping quantitative trait ...DPR trait was ...for mapping quanti- tative trait loci in order to overcome the uncertain segregation status at putative loci ...
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Rapid and robust association mapping of expression quantitative trait loci
... In this article, we present our analysis of the Genetic Anal- ysis Workshop 15 (GAW15) gene expression data set (Problem 1) originating from Morley et al. [4]. We con- ducted family-based association mapping using ...
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Mapping of Quantitative Trait Loci Controlling Adaptive Traits in Coastal Douglas Fir. III. Quantitative Trait Loci-by-Environment Interactions
... Hurme, P., M. J. Sillanpa¨a¨, E. Arjas, T. Repo and O. Savolainen, supported by the United States Department of Agriculture Coopera- 2000 Genetic basis of climatic adaptation in Scots pine by Bayes- tive State Research, ...
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A Statistical Framework for Quantitative Trait Mapping
... Many complex trait studies involve measurement of The use of marker loci as covariates in QTL analysis multiple related phenotypes. If two phenotypic mea- was suggested by Jansen (1993) and also by Zeng ...
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Mapping Quantitative Trait Loci by Controlling Polygenic Background Effects
... QTL mapping (genome-wide linkage studies) is slightly different from GWAS because the target populations for the two approaches of genetic mapping are often ...QTL mapping to capture the background ...
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Varying Coefficient Models for Mapping Quantitative Trait Loci Using Recombinant Inbred Intercrosses
... Varying coefficient models are very useful statistical tools for exploring dynamic effects. The varying coefficient models were introduced by Cleveland et al. (1991), and discussed by Hastie and Tibshirani (1993) in more ...
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Marker Pair Selection for Mapping Quantitative Trait Loci
... tects a QTL and when it must be considered as a “sub- easily be 50% or more (Southey and Fernando 1998). peak” of another detecting peak, selection of cofactors, Model selection criteria are based on a philosophy ML, or ...
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Multiple trait analysis of genetic mapping for quantitative trait loci.
... We examined, in detail, various advantages and disadvantages of the joint analysis as compared to sepa- rate analyses for mapping QTL and also for testing a number of hyp[r] ...
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