[PDF] Top 20 Disequilibrium in two-locus mutation-selection balance models.
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Disequilibrium in two-locus mutation-selection balance models.
... FELDMAN, CHRISTIANSEN, and BROOKS (1980) show that if disequilibrium generated by mutation selection balance is positive, modifiers which increase recombination rate will [r] ... See full document
5
DISEQUILIBRIUM, SELECTION, AND RECOMBINATION: LIMITS IN TWO-LOCUS, TWO-ALLELE MODELS
... Given particular equilibrium values of chromosomal frequencies at two loci, constraints have been found on the relationship between the maximum value of recombination and the m[r] ... See full document
10
Linkage and the maintenance of heritable variation by mutation-selection balance.
... two-locus models. Cambridge University Press. FELDMAN, 1970 Linkage and selection: two locus symmetric viability model. HILL, 1988 Quantitative genetic variability maintained b[r] ... See full document
10
THE INTERACTION OF SELECTION AND LINKAGE. I. GENERAL CONSIDERATIONS; HETEROTIC MODELS
... Specific numerical cases for two- and five-locus models exhibiting heterosis have been examined with the following results: (1) Loci may be kept in permanent linkage disequilibrium d[r] ... See full document
19
Adaptive Fixation in Two-Locus Models of Stabilizing Selection and Genetic Drift
... genetics models of stabilizing selection also be used to predict observed levels of selective fixations? Chevin and Hospital (2008) presented a model for the footprint of positive directional ... See full document
13
Asexual but Not Clonal: Evolutionary Processes in Automictic Populations
... and two loci, depending on the number of crossovers between loci and centromere, a number of models are developed to gain a better understanding of basic evolutionary processes in automictic ...size, ... See full document
17
The Population Genetics of Synthetic Lethals
... a mutation- selection balance for the complete haploid model and selected cases of the diploid ...single mutation) are comparable to analogous single-locus results, after allowing for ... See full document
10
Mutation-Selection Balance, Dominance and the Maintenance of Sex
... for mutation the necessary advantage (for reviews, see Bell 1982; rates per genome of order unity even for the simpler Kondrashov 1993; Crow 1994; Hurst and Peck 1996; and more general situation in which ... See full document
7
The Evolution of Recombination in a Heterogeneous Environment
... Most models describing the evolution of recombination have focused on the case of a single population, implicitly assuming that all individuals are equally likely to mate and that spatial heterogeneity in ... See full document
16
Mutation-Selection Balance at a Modifier-of-Imprinting Locus
... The models predict the stable equilibrium frequencies of the mutant modifier and functionally diploid individuals in a large population in terms of up to four parameters: the m[r] ... See full document
7
Dynamic Mutation–Selection Balance as an Evolutionary Attractor
... dynamic balance state has important implications for patterns of molecular ...purifying selection on the structure of genealogies has suggested that Muller’s ratchet plays a crucial role in determining the ... See full document
18
HiSSI: high-order SNP-SNP interactions detection based on efficient significant pattern and differential evolution
... POU5F1, which plays a key role in embryonic develop- ment and stem cell pluripotency [31]. rs2523608 is located at gene HLA-B and belongs to human leukocyte antigen (HLA) class I heavy chain paralogs. HLA class I anti- ... See full document
12
Mutation-selection balance and metabolic control theory.
... Changes in activity of an enzyme will affect the immediately flanking metabolite pools more than pools more distant in the pathway (as is the case for the human inborn e[r] ... See full document
15
Pleiotropic models of polygenic variation, stabilizing selection, and epistasis.
... Stabilizing selection is also observed if the polygenic system is at an equilibrium determined by a balance between selection and mutation (or migration) when both additive an[r] ... See full document
17
Modelling Genetic Algorithms and Evolving Populations
... first two ensemble cumulants and C, the full dynamics of a genetic algorithm using ranking selection with either roulette wheel selection or stochas- tic universal sampling can be ...first two ... See full document
122
Two-Locus Sampling Distributions and Their Application
... neutral mutation rate at each locus is native to solving Golding’s recursion is to estimate the denoted u, and the recombination rate between the two two-locus sample probabilities by ... See full document
13
Pleiotropic models of quantitative variation.
... HILL, 1989 Quantitative genetic variability maintained by mutation-selection balance: sampling variation and response to subsequent directional selection. KACSER, 1987 Dominance,[r] ... See full document
10
Multivariate mutation-selection balance with constrained pleiotropic effects.
... In terms of quantitative genetic theory this means that the possi- ble pleiotropic effects of quantitative genetic variation are most often not changed by mutations at [r] ... See full document
12
ANALYSIS OF COMPLEX ALLOZYME POLYMORPHISMS IN A BARLEY POPULATION
... Gametic phase disequilibrium: The gametic phase disequilibrium parameter (also called linkage disequilibrium. epistatic disequilibrium, gametic phase un- balance, disequilibri[r] ... See full document
19
Population Models of Genomic Imprinting. I. Differential Viability in the Sexes and the Analogy With Genetic Dominance
... single-locus, two-allele selection models of genomic imprinting have been shown to reduce formally to one-locus Mendelian models with a modified parameter for genetic ...where ... See full document
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