[PDF] Top 20 Effects of Herpes Simplex Virus on Structure and Function of Nectin-1/HveC

... Herpes simplex virus (HSV) entry requires the interaction between the envelope glycoprotein D (gD) and a cellular receptor such as nectin-1 (also named herpesvirus entry mediator C ... See full document

... the virus in cells of the epithelium and for pro- gression from the initial sites of infection to neurons and cells of the immune ...that function on target ...that nectin-1 is the primary, if ... See full document

... of nectin-1 in CD4 and in the poliovirus receptor have been shown to be critical for interactions with human immu- nodeficiency virus and poliovirus, respectively (1, 4, 31, ...as virus ... See full document

... residues 1 to 285), which according to previ- ous reports (32–34) shows a much higher affinity for receptors than the longer gD form (spanning residues 1 to 306), the molec- ular basis of the binding ... See full document

... mouse nectin-2 may cause steric hindrance (or a different conformational structure in that area) to prevent HSV ...human nectin-2, FIG. 3. Alignment of human and mouse nectin-2 sequences in ... See full document

... Herpes simplex virus (HSV) is an enveloped, double- stranded DNA virus which is an important human pathogen ...which function in viral entry. At least seven glycoproteins func- tion in ... See full document

... of herpes simplex virus (HSV) is essential for virus ...type 1 (HSV-1) [gD-1(306t)] and HSV-2 [gD-2(306t)] and four mutants, gD-1( = 34t), gD-1( = 126t), ... See full document

... into nectin-1-deficient primary dermal fibro- ...of nectin-1 to HSV-1 entry into dermal fibroblasts, we isolated fibroblasts from newborn skin of either wt or ... See full document

... HSV-1 virus in which the capsid protein VP26 is fused to the mRFP) and PK15 cells were infected with wild-type ...of 1 frame every 2 s for 120 s and are shown at a rate of 10 ... See full document

... or nectin-1 have been studied extensively in different cell lines, little is known about the receptors that mediate uptake of HSV-1 in vivo at the natural sites of virus ...with ... See full document

... When we analyzed each of the mutants in a complementation assay for virus function 38, only two mutant proteins, Cys-2 and Cys-4, Glycoprotein D gD of herpes simplex virus HSV is a struc[r] ... See full document

... Individual polypeptides that contained single insertions of 2 to 28 amino acids throughout the external domain were not recognized or were recognized poorly by antibodies specific for si[r] ... See full document

... a virus lacking ICP27, indicating that these sites have no appar- ent role in viral replication in cell ...The effects of these mutations in vivo will require further ... See full document

... Cysteine mutants of herpes simplex virus type 1 glycoprotein D exhibit temperature-sensitive properties in structure and function.. Glycoprotein D protects mice against lethal challenge [r] ... See full document

... the nectin-1- ⌬ 2 protein through the exocytic pathway, we studied its electrophoretic mobility after endoglycosidase ...F. Nectin-1 and nectin-1- ⌬ 2, tagged at the C terminus ... See full document

... (ii) Nectin-1 or herpesvirus entry mediator C (HveC; also referred to as poliovirus receptor-related protein 1) is a mem- ber of the nectin family of adhesion molecules belonging to the ... See full document

... of nectin-1 ␣ with ...of nectin-1␣ with afadin is involved in entry and/or cell-cell spread of HSV-1, we used L cells stably ex- pressing the full length of human ... See full document

... gD, nectin-1, and ...The nectin-1 amino acids comprising the variable-like (V) and constant-like (C) Ig domains are labeled, as are the disulfide bonds that define these domains ...the ... See full document

... In this report, we present an alignment of the amino acid sequence of HSV-1 pol into three distinct catalytic domains RNase H, 3'-5'-exonuclease, and DNA polymerase, respectively, evalua[r] ... See full document

... of virus-host ...in herpes simplex virus 1 (HSV-1) infec- tion have not fully been ...of virus and less lung pathological change following HSV-1 ... See full document