[PDF] Top 20 Enhancer and Long-Term Expression Functions of Herpes Simplex Virus Type 1 Latency-Associated Promoter Are both Located in the Same Region
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Enhancer and Long-Term Expression Functions of Herpes Simplex Virus Type 1 Latency-Associated Promoter Are both Located in the Same Region
... the enhancer activity within the region upstream of the LAT ...the enhancer activity found to be associated with the LTE fragment seemed to be reduced only partially when part of the 5⬘ end of ... See full document
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Utilization of the herpes simplex virus type 1 latency-associated regulatory region to drive stable reporter gene expression in the nervous system.
... HSV type 1 (HSV-1) recombinants containing reporter gene constructs inserted downstream of all currently recognized LAT regulatory sequence ...encephalomyocarditis virus (EMCV) internal ... See full document
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The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... LAT enhancer may play a role in maintaining a tran- scriptionally permissive chromatin structure of this ...the region containing the 5 ⬘ exon of LAT seems to be independent of detectable LAT transcription, ... See full document
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Analysis of the promoter and cis-acting elements regulating expression of herpes simplex virus type 2 latency-associated transcripts.
... neurons, herpes simplex virus type 2 (HSV-2) expresses one abundant family of tran- scripts, the latency-associated transcripts ...strong promoter in transient ... See full document
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Analysis of Protein Expression from within the Region Encoding the 2.0-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 1
... (Fig. 1) served as the parental construct from which all other clones were ...CMV promoter was deleted from pLAT(H)GFP⫹ to generate the plasmid p⌬CMV ...site, located in the pLAT(X)GFP⫹ polylinker ... See full document
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A Chromatin Insulator-Like Element in the Herpes Simplex Virus Type 1 Latency-Associated Transcript Region Binds CCCTC-Binding Factor and Displays Enhancer-Blocking and Silencing Activities
... displays enhancer-blocking and silencing activities, common features of cellular ...is located downstream of the LAT enhancer/ rcr and upstream of the lytic gene ICP0 transcription termina- tion ... See full document
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A 348-base-pair region in the latency-associated transcript facilitates herpes simplex virus type 1 reactivation.
... (LAT) promoter deletion mutants of herpes simplex virus type 1 have a reduced capacity to reactivate following adrenergic induction in the rabbit eye ...LAT region to form ... See full document
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Herpes Simplex Virus Latency-Associated Transcript Sequence Downstream of the Promoter Influences Type-Specific Reactivation and Viral Neurotropism
... During latency, HSV-1 and HSV2-LAT-S1 did not re- activate ...lasting 1 to 2 days, similar in character to recurrences produced by HSV-2, HSV2-LAT-P1, and ...LAT region deletion mutants, ... See full document
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Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... the region of the ...the region that was deleted in the LAT null ...the expression of any known HSV-1 genes other than ...genes located in the unique long portion of the genome ... See full document
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Region of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sufficient for Wild-Type Spontaneous Reactivation Promotes Cell Survival in Tissue Culture
... enhance expression of genes encoded by plasmids, because sodium butyrate can inhibit histone deacetylase activity ...(5). Long-term treatment of cell lines with sodium butyrate can lead to apoptosis ... See full document
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cis-acting elements involved in transcriptional regulation of the herpes simplex virus type 1 latency-associated promoter 1 (LAP1) in vitro and in vivo.
... Latency-associated promoter 1 (LAP1) of herpes simplex virus type 1 is required to generate a series of latency-associated transcripts (LATs) ... See full document
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Evidence for a Bidirectional Element Located Downstream from the Herpes Simplex Virus Type 1 Latency-Associated Promoter That Increases Its Activity during Latency
... of expression of the LAT-LTE vi- ruses at 28 days is considerably higher than that observed in virus-infected ganglia such as KOS18, which lack the LTE ...of expression that is slowly decreased, and ... See full document
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The latency-associated promoter of herpes simplex virus type 1 requires a region downstream of the transcription start site for long-term expression during latency.
... The latency-associated transcript (LAT) promoter of herpes simplex virus type 1 (HSV-1) is unique among the many promoters on the viral genome in that it ... See full document
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In vivo deletion analysis of the herpes simplex virus type 1 latency-associated transcript promoter.
... LAT promoter, and all of these sequences have been placed into the long unique ...LAT promoter function, because b -galacto- sidase activity is gradually lost over the course of several ...for ... See full document
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Detection of herpes simplex virus type 1 latency-associated transcript expression in trigeminal ganglia by in situ reverse transcriptase PCR.
... LAT expression detected by ISH as a measure of the number of genome- containing cells underestimates the number of latent HSV genome-containing cells in a trigeminal ...LAT expression, the majority of cells ... See full document
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In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... LAT promoter mutants exhibit a reduction in genome copy numbers 2- to 3-fold within sensory ganglia compared to wild-type HSV, presumably due to the LAT’s ability to protect neurons from apoptosis (9, 19) ... See full document
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Localization of cis-acting sequence requirements in the promoter of the latency-associated transcript of herpes simplex virus type 1 required for cell-type-specific activity.
... Our current data demonstrate that the IC-1 factor is selectively present in the human neuroblastoma cells IMR-32 compared with HeLa cells and binds a DNA sequence which is selectively re[r] ... See full document
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The nucleotide sequence, 5' end, promoter domain, and kinetics of expression of the gene encoding the herpes simplex virus type 2 latency-associated transcript.
... The 5619 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest The sequence of the herpes simplex virus type 2 HSV-2 latency-associated transcript LAT region resembles that o[r] ... See full document
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Identification of Herpes Simplex Virus Type 1 Latency-Associated Transcript Sequences That both Inhibit Apoptosis and Enhance the Spontaneous Reactivation Phenotype
... (the region deleted in ...apoptosis region that maps somewhere between LAT nucleo- tides 447 and 2850, with at least part of this functional region being located between LAT nucleotides 1500 ... See full document
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A novel latency-active promoter is contained within the herpes simplex virus type 1 UL flanking repeats.
... The nucleotide sequence, 5' end, promoter domain, and kinetics of expression of the gene encoding the herpes simplex virus type 2 latency-associated transcript.. Promoter of the latency-[r] ... See full document
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