[PDF] Top 20 EVIDENCE FOR BALANCING SELECTION AT HLA
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EVIDENCE FOR BALANCING SELECTION AT HLA
... As a result of this consideration of possible causes for the observed reduced homozygosity it appears that some form of symmetrical balancing selection, and not stratificat[r] ... See full document
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Genetics and evidence for balancing selection of a sex-linked colour polymorphism in a songbird
... sexual selection and speciation, yet the mechanisms that generate and maintain them are not fully ...no evidence that an inversion is involved in maintaining the distinct ... See full document
12
Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA
... of balancing selec- tion on SDHA despite the presence of six singleton vari- ants in the African American samples and one singleton variant in the European American samples (Additional file ... See full document
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Correlates of Protective Cellular Immunity Revealed by Analysis of Population-Level Immune Escape Pathways in HIV-1
... within HLA types/subtypes across the HIV-1 pro- teome, we applied recently developed techniques (26; see also Ma- terials and Methods) to explicitly test for differential escape (de- fined here as cases where one ... See full document
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The Implications of Intergenic Polymorphism for Major Histocompatibility Complex Evolution
... the HLA-B locus (Leelayuwat et ...to HLA-B is DIST locus that is the closest to HLA-B (Figure 1, Table limited by the choice of ...the HLA-B locus their serologically determined HLA ... See full document
11
Distinct Escape Pathway by Hepatitis C Virus Genotype 1a from a Dominant CD8+ T Cell Response by Selection of Altered Epitope Processing
... because evidence for HLA-B*51-associ- ated selection pressure was only observed in the epitope flanking ...second HLA-B*51 binding motif by analysis with prediction algorithms for HLA ... See full document
10
A humanized model of experimental autoimmune uveitis in HLA class II transgenic mice
... in HLA class II TG mice described here provides evidence in favor of an involvement of class II–restricted responses in human ...of HLA-DR3 TG mice to disease induced with ...of HLA-DR3 TG ... See full document
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HLA-B*57 Micropolymorphism Shapes HLA Allele-Specific Epitope Immunogenicity, Selection Pressure, and HIV Immune Control
... between HLA-B*5703 and B*5702 on peptide presentation was highly ev- ident, as these alleles share only 50% of the HIV epitopes, with 7 more epitopes targeted by HLA-B*5703 than by ...by HLA- B*5703 ... See full document
11
Understanding rare and common diseases in the context of human evolution
... that balancing selection is more prevalent than previously thought (see [27] for a ...long-term balancing selection in the genomes of humans and chimpanzees has detected 125 regions containing ... See full document
14
Selection on Glycine β-1,3-Endoglucanase Genes Differentially Inhibited by a Phytophthora Glucanase Inhibitor Protein
... actions. Analysis of molecular variation at plant R-genes Plant cells are surrounded by rigid walls composed of that function in recognition of invading pathogens has complex polysaccharides and diverse proteins (Carpita ... See full document
12
Molecular evolution of the sheep prion protein gene
... experimental evidence supports the idea that PRNP heterozygotes are more TSE-resistant than homozygotes in both humans (Mead et ...empirical evidence that the conversion of the normal form of PrP (PrP c ) ... See full document
8
Detecting Ancient Balancing Selection: Methods And Application To Human
... Balancing selection can maintain genetic variation in a population over long evolutionary time ...of selection not only elucidates selective pressures and adaptations but can also help interpret ... See full document
121
Lack of strong immune selection pressure by the immunodominant, HLA A*0201 restricted cytotoxic T lymphocyte response in chronic human immunodeficiency virus 1 infection
... analyzed HLA-A*0201 restricted cytotoxic T lymphocyte responses in 17 HIV-1–infected individuals with viral loads ranging from , 400 to 221,000 HIV RNA molecules per milliliter of ...other HLA-A*0201 re- ... See full document
9
Pooled DNA sequencing identifies genomic regions of selection in Nigerian isolates of Plasmodium falciparum
... Recent advances in next-generation genomics have proved useful in individual sequencing of P. falciparum in order to identify genes with polymorphic site fre- quency spectra consistent with selection. However, ... See full document
7
High expression of HLA E in colorectal carcinoma is associated with a favorable prognosis
... upon HLA-E assembly with peptides from donor proteins other than HLA class I; (b) the direct engagement of the activating NKG2C receptor isoform; and (c) antigen-specific recog- nition through the T cell ... See full document
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Online Full Text
... parent selection process, while sensor nodes with the highest residual energy levels are considered ...route selection process during the route searching phase by utilizing the principle of the min-max cost ... See full document
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A SPECTRUM SELECTION FRAMEWORK FOR MOBILITY MANAGEMENT IN COGNITIVE RADIO CELLULAR NETWORK
... Abstract : Cognitive radio (CR) offer solution to the spectrum inefficiency by using the spectrum holes in space without introducing any sort of interference to the primary user. It also solves the spectrum inefficiency ... See full document
9
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... between HLA and disease are of considerable importance as they provide new tools for studying the inheritance, classifica- tion, diagnosis and pathogenesis of the disease in ...that HLA associations between ... See full document
7
Balancing Selection at Closely Linked, Overdominant Loci in a Finite Population
... locally stable under the restricted ranges of values of ␣, We begin with the analysis of the case in which c ⫽ , and ␥ considered here. If ε ⱕ 0, no equilibrium with 0, for which an analytic approximation can be ... See full document
12
Recombination, Balancing Selection and Phylogenies in MHC and Self-Incompatibility Genes
... of the genealogical tree remain unaffected? How far, measured in recombination distance, is the effect of selection measurable? The last question follows Hudson and Kaplan (1988) and Takahata and Satta (1998). ... See full document
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