[PDF] Top 20 The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
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The herpes simplex virus type 1 latency-associated transcript gene regulates the establishment of latency.
... viral gene tran- scription in neurons ...wild type in its ability to reactivate in a timely manner in an in vitro cocultivation assay, as well as in establishment as measured by in situ PCR ...of ... See full document
9
Herpes Simplex Virus type 1 lytic viral gene expression during the establishment and maintenance of latency
... that latency is established at equivalent levels in the absence of LAT ...of latency, as manifest by the stability of the viral genome over ...which latency is established in mice infected with a ... See full document
353
Downstream regulatory elements increase acute and latent herpes simplex virus type 2 latency-associated transcript expression but do not influence recurrence phenotype or establishment of latency.
... inoculation, herpes simplex virus (HSV) establishes latency in the sensory ganglia inner- vating that ...the virus may reactivate to cause symptomatic or asymptomatic recurrences (4, ... See full document
7
Influence of Herpes Simplex Virus 1 Latency-Associated Transcripts on the Establishment and Maintenance of Latency in the ROSA26R Reporter Mouse Model
... the establishment or maintenance of infection or for reactivation from latency (15, 36, ...for latency establishment, sug- gesting that the LATs function during entry into latency, ... See full document
11
The Latency-Associated Transcript Gene Enhances Establishment of Herpes Simplex Virus Type 1 Latency in Rabbits
... The latency-associated transcript (LAT) gene the only herpes simplex virus type 1 (HSV-1) gene abundantly transcribed during neuronal ... See full document
7
The 2.2-Kilobase Latency-Associated Transcript of Herpes Simplex Virus Type 2 Does Not Modulate Viral Replication, Reactivation, or Establishment of Latency in Transgenic Mice
... (Fig. 1), included a 5,277-bp genomic DNA fragment of HSV-2 strain 333 consisting of the sequences 1,167 bp upstream and 4,114 bp downstream of the LAT transcription initiation site ...(Fig. 1) was added to ... See full document
7
PrPc Expression Influences the Establishment of Herpes Simplex Virus Type 1 Latency
... the virus, with a resultant increase in viral patho- ...infectious virus was measured in periph- eral lymphoid tissue, it was clear that while tga20 mice re- sponded quicker to the viral challenge, levels ... See full document
12
Herpes simplex virus type 1 latency-associated transcription unit promotes anatomical site-dependent establishment and reactivation from latency.
... A comparison of the induced reactivation frequencies of KOSM, KOS/1, KOS/29, and KOS/62 clearly demonstrates that both LATs- mutants KOS/29 and KOS/62 reactivated with a greatly reduced [r] ... See full document
13
Herpes Simplex Virus Type 1 Latency-Associated Transcript Gene Promotes Neuronal Survival
... LAT gene inhibits the death of sensory neurons is also not ...the establishment of ...immediate-early gene expression is reduced or eliminated and a latent infection that contains hundreds or even ... See full document
16
Evidence that two latency-associated transcripts of herpes simplex virus type 1 are nonlinear.
... Our studies provide a clue as to why the LATs are relatively stable. However, we are still left with the question of whether this RNA has any function, especially in terms of HSV latency. As reviewed in the ... See full document
6
The Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Enhancer/rcr Is Hyperacetylated during Latency Independently of LAT Transcription
... one type of posttranslational modification that can be present at specific histone amino acid residues, and acetylation of lysines 9 and 14 of histone H3 is typically enriched in transcriptionally permis- sive ... See full document
11
Tissue-Specific Splicing of the Herpes Simplex Virus Type 1 Latency-Associated Transcript (LAT) Intron in LAT Transgenic Mice
... of herpes simplex virus type 1 (HSV-1) latency-associated transcript (LAT) expres- sion and processing in the absence of other cis and trans viral functions, ... See full document
10
CTCF-Dependent Chromatin Boundary Element between the Latency-Associated Transcript and ICP0 Promoters in the Herpes Simplex Virus Type 1 Genome
... activity associated with the larger ...RFP gene in transfected S3 ...the latency specific LAT gene away from the neigh- boring, silenced lytic specific ...Epstein-Barr virus, the CTCF ... See full document
10
Neuronal Subtype Determines Herpes Simplex Virus 1 Latency-Associated-Transcript Promoter Activity during Latency
... ABSTRACT Herpes simplex virus (HSV) latency in neurons remains poorly under- stood, and the heterogeneity of the sensory nervous system complicates mechanis- tic ...express ... See full document
15
In Vivo Knockdown of the Herpes Simplex Virus 1 Latency-Associated Transcript Reduces Reactivation from Latency
... During herpes simplex virus (HSV) latency, most viral genes are si- lenced, with the exception of one region of the genome encoding the latency- associated transcript ... See full document
10
Herpes Simplex Virus Type 1 2-Kilobase Latency-Associated Transcript Intron Associates with Ribosomal Proteins and Splicing Factors
... The 2-kb LAT RNA associates with ribosomal subunits with the affinity of rRNAs—an association that has greater affinity than that of cellular mRNAs and actively translating viral mRNAs. The 28S rRNA plays a critical role ... See full document
11
A herpes simplex virus type 1 latency-associated transcript mutant reactivates with normal kinetics from latent infection.
... Expression of herpes simplex virus type 1 latency-associated transcripts in the trigeminal ganglia of mice during acute infection and reactivation of latent infection.. Expression of her[r] ... See full document
10
The herpes simplex virus type 1 2.0-kilobase latency-associated transcript is a stable intron which branches at a guanosine.
... The branch point of the 2.0-kb LAT intron is a guanosine. It was recently reported that a portion of the 2.0-kb LAT has a nonlinear configuration, most likely a lariat (67). Because the 2.0-kb LAT is an intron, some of ... See full document
10
Herpes Simplex Virus Type 1 Latency-Associated Transcript Expression Protects Trigeminal Ganglion Neurons from Apoptosis
... HSV latency is less ...down regulates expression of antigen associated with major histocompatibility complex class I, thereby allowing infected cells to evade cell-mediated immu- nity ... See full document
7
Detection of herpes simplex virus type 1 latency-associated transcript expression in trigeminal ganglia by in situ reverse transcriptase PCR.
... with 1% HCl in PBS for 15 min (instead of the 5 min employed in the ISPCR), rinsed in RNase-free PBS, and then treated with 400 U of RNase-free DNase (Worthington Bio- chemicals) and 10 U of RNasin (Promega) in ... See full document
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