[PDF] Top 20 Mutations in HIV-1 Reverse Transcriptase Affect the Errors Made in a Single Cycle of Viral Replication
Has 10000 "Mutations in HIV-1 Reverse Transcriptase Affect the Errors Made in a Single Cycle of Viral Replication" found on our website. Below are the top 20 most common "Mutations in HIV-1 Reverse Transcriptase Affect the Errors Made in a Single Cycle of Viral Replication".
Mutations in HIV-1 Reverse Transcriptase Affect the Errors Made in a Single Cycle of Viral Replication
... of mutations in the 153-nt sequence of lacZ ␣ were detailed in 2-by-153 tables for each pairwise comparison of the lacZ ␣ mutational ...of mutations into smaller 2-by-n tables for which n was considerably ... See full document
13
Nature, Position, and Frequency of Mutations Made in a Single Cycle of HIV-1 Replication
... vivo mutations. Although the integrated HIV-1 genome is double-stranded DNA, only one strand is copied into viral RNA by the host DNA-dependent RNA Pol ...the viral DNA, the minus ... See full document
15
Compensation by the E138K Mutation in HIV-1 Reverse Transcriptase for Deficits in Viral Replication Capacity and Enzyme Processivity Associated with the M184I/V Mutations
... nant HIV-1 NL4-3 viruses harboring E138K and M184I/V dou- ble mutations possessed high-level resistance to FTC and 3TC, as does the M184I/V single mutation, and possessed modest resistance to ... See full document
9
Mutations That Abrogate Human Immunodeficiency Virus Type 1 Reverse Transcriptase Dimerization Affect Maturation of the Reverse Transcriptase Heterodimer
... of mutations that abrogate human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) dimerization on virus replication is not known, as mutations shown ... See full document
11
Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication
... the viral life cycle affected by these particular amino acid substitutions, as well as substitutions at other IN po- sitions within the putative RT-binding surface, was analyzed in this ...for ... See full document
12
A Novel Leu92 Mutant of HIV-1 Reverse Transcriptase with a Selective Deficiency in Strand Transfer Causes a Loss of Viral Replication
... IMPORTANCE Reverse transcription in retroviruses is essential for the viral life ...by viral reverse trans- criptase, which copies the viral RNA into DNA by its DNA polymerase activity ... See full document
11
Inhibitory effect of aqueous dandelion extract on HIV 1 replication and reverse transcriptase activity
... that single oral dose of bevirimat, derived from a betulinic acid-like compound, was well tolerated and demonstrated a dose- dependent reduction in viral ...primary HIV-1 isolates by targeting ... See full document
10
A Single Amino Acid Substitution in HIV-1 Reverse Transcriptase Significantly Reduces Virion Release
... nonnucleoside reverse transcriptase inhibitor) on PR-mediated virus processing ...significantly affect virus particle assembly or processing, but it does markedly impair viral infectivity in a ... See full document
7
The RNA binding protein HuR does not interact directly with HIV 1 reverse transcriptase and does not affect reverse transcription in vitro
... of viral reverse ...the HIV-1 RT- HuR interaction at the atomic level and to elucidate the mechanism(s) by which HuR influences HIV-1 reverse transcription activity in ... See full document
7
Reduced Fitness in Cell Culture of HIV-1 with Nonnucleoside Reverse Transcriptase Inhibitor-Resistant Mutations Correlates with Relative Levels of Reverse Transcriptase Content and RNase H Activity in Virions
... of viral replication ...was made by annealing a 5⬘-end-labeled 41-nt RNA to a 77-nt DNA primer such that the 5 ⬘ end of the RNA was recessed relative to the ... See full document
13
The Effects of Alternate Polypurine Tracts (PPTs) and Mutations of Sequences Adjacent to the PPT on Viral Replication and Cleavage Specificity of the Rous Sarcoma Virus Reverse Transcriptase
... of reverse transcriptase ...linear viral DNA. To better understand the RNase H cleavage by RSV RT, we made a number of mutations within the DuckHepBFlipPPT and in the sequences adjacent ... See full document
13
Targeting human immunodeficiency virus type 1 reverse transcriptase by intracellular expression of single-chain variable fragments to inhibit early stages of the viral life cycle.
... restrict HIV-1 replication in human ...the HIV-1-permis- sive cells resistant to wild-type growth of several strains of ...cells, HIV-1 propagation was restricted at early ... See full document
13
The Connection Domain Mutation N348I in HIV-1 Reverse Transcriptase Enhances Resistance to Etravirine and Rilpivirine but Restricts the Emergence of the E138K Resistance Mutation by Diminishing Viral Replication Capacity
... M184V/N348I mutations into the HIV-1 NL ...performed viral passage experi- ments in CBMCs using increasing drug concentrations over a pe- riod of 19 ...Figure 1 shows the weekly ... See full document
12
Replication competent HIV-1 viruses that express intragenomic microRNA reveal discrete RNA-interference mechanisms that affect viral replication
... Total RNA was extracted from the cells at 48 hours post transfection. RNA was treated with DNase, and cDNA was made by reverse transcriptase reaction using either poly dT (dT) or random hexamer ... See full document
13
Subtype associated differences in HIV 1 reverse transcription affect the viral replication
... the replication of ...of reverse transcription products in virions and reverse transcription complexes (RTCs), viral DNA integration, the frequency of point mutations in the pro- virus, ... See full document
18
Inhibition of RNase H activity and viral replication by single mutations in the 3' region of Moloney murine leukemia virus reverse transcriptase.
... Selected conserved amino acids in the putative RNase H domain of reverse transcriptase (RT) were modified in a molecularly cloned infectious provirus and in a Moloney murine leukemia vir[r] ... See full document
5
The Cellular Antiviral Protein APOBEC3G Interacts with HIV-1 Reverse Transcriptase and Inhibits Its Function during Viral Replication
... and viral protein Gag p24 in each viral sample was analyzed by WB with anti-A3G (upper panel) and anti-p24 (lower panel) ...on HIV-1 reverse transcription and viral ... See full document
10
Molecular Mechanism of Antagonism between the Y181C and E138K Mutations in HIV-1 Reverse Transcriptase
... M184I/V mutations, leading to high-level resis- tance to both 3TC and FTC (47, ...two mutations in tandem caused decreased dNTP binding and that the presence of E138K decreased levels of resistance con- ... See full document
8
The role of the HIV-1 reverse transcriptase mutation H208Y to drug resistance and viral fitness
... of single dose nevirapine to prevent mother to child transmission, patients experiencing virological failure and patients with transmitted drug resistance (Lecossier et ...and single genome sequencing (SGS) ... See full document
299
Mutations That Confer Resistance to Template-Analog Inhibitors of Human Immunodeficiency Virus (HIV) Type 1 Reverse Transcriptase Lead to Severe Defects in HIV Replication
... of viral resistance, is less likely to be a problem in the case of TRTIs caused by pertur- bation of critical functions intrinsic to HIV-1 ...whether mutations conferring resistance to TRTIs ... See full document
5
Related subjects