[PDF] Top 20 DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants.
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DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants.
... The remaining mutants studied, all of which were DNA- at 39 C Table 1, fell into three categories with respect to their ability to induce DP activity at 39 C Table 2: i mutants belonging[r] ... See full document
10
Herpes Simplex Virus DNA Packaging without Measurable DNA Synthesis
... tsProt.A temperature-sensitive mutant could lead to conclusions not relevant to a normal viral infection, and it is certainly possible that under normal conditions the processes of replication and packaging ... See full document
7
Electron microscope studies of temperature-sensitive mutants of herpes simplex virus type 2.
... For infectivity assay a 1.5-ml sample of infected cell suspension was frozen, thawed, and then sonicated for 1 min at 10 kcycles/s with a 727 Downloaded from http://jvi.asm.org/ on Novem[r] ... See full document
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Viral DNA synthesis in cells infected with temperature-sensitive mutants of herpes simplex virus type 1.
... and 10% vol/vol tryptose phosphate broth Difco on 314 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Temperature-sensitive mutants of herpes simplex virus type 1 repre[r] ... See full document
6
Finger Domain Mutation Affects Enzyme Activity, DNA Replication Efficiency, and Fidelity of an Exonuclease-Deficient DNA Polymerase of Herpes Simplex Virus Type 1
... merase activity to extend from mismatched primer termini to achieve the higher ...proofreading activity (1, 25, 26) and that the L774F mutant Pol exhibits poor extension from mismatched primer ... See full document
8
A temperature-sensitive mutation in a herpes simplex virus type 1 gene required for viral DNA synthesis maps to coordinates 0.609 through 0.614 in UL.
... At the nonpermissive temperature, ts701 i failed to induce the synthesis of viral DNA, ii exhibited a dramatically reduced ability to drive replication of a plasmid containing the herpes[r] ... See full document
7
Temperature-sensitive mutants in herpes simplex virus type 1 ICP4 permissive for early gene expression.
... Fifteen to fifty percent of wild-type levels of viral DNA are synthesized at the nonpermissive temperature in ts48- and ts303-infected cells, indicating that immediate-early and early ge[r] ... See full document
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Inhibition of herpes simplex virus type 1 DNA polymerase activity by peptides from the UL42 accessory protein is largely nonspecific.
... MARSDEN"* Medical Research Council Virology Unit, Church Street, Glasgow Gll SJR,' and Glaxo Group Research Ltd., Greenford, Middlesex UB6 OHE,2 United Kingdom, and Laboratory of Viral D[r] ... See full document
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Effects of Exonuclease Activity and Nucleotide Selectivity of the Herpes Simplex Virus DNA Polymerase on the Fidelity of DNA Replication In Vivo
... with virus at a multiplicity of ...8.0], 1 mM EDTA, 150 mM NaCl), and then 1 ml of TNE was ...Total DNA was then digested with HindIII and fractionated on a ...The DNA sample with a ... See full document
7
Branched structures in the intracellular DNA of herpes simplex virus type 1.
... of activity occurs late in infection, and it coincides with the production of mature linear genomes in HSV-1, cytomegalovirus (our unpublished results), and Ep- stein-Barr virus ...its DNA to ... See full document
7
Expression of herpes simplex virus type 1 DNA polymerase in Saccharomyces cerevisiae and detection of virus-specific enzyme activity in cell-free lysates.
... Cell extracts from a strain of Saccharomyces cerevisiae harboring this vector Y-MH202, expresser cells grown in the presence of galactose and assayed in high salt 100 mM ammonium sulfate[r] ... See full document
6
Expression of herpes simplex virus type 1 DNA polymerase gene by in vitro translation and effects of gene deletions on activity.
... The in vitro translated pol gene product was enzymatically active, with salt resistance and sensitivity to acyclovir triphosphate, similar to the enzyme activity in crude extracts of her[r] ... See full document
9
Processing of Lagging-Strand Intermediates In Vitro by Herpes Simplex Virus Type 1 DNA Polymerase
... gap-filling activity of HSV-1 pol, even in the presence of the strand displacement activity of exo ⫺ pol, did not explain how lagging-strand intermediates could be processed by wild-type pol, ... See full document
14
Acyclovir-resistant mutants of herpes simplex virus type 1 express altered DNA polymerase or reduced acyclovir phosphorylating activities.
... BWr, a new acyclovir-resistant mutant derived from the Patton strain of herpes simplex virus type 1, induced a DNA polymerase resistant to inhibition by acyclovir triphosphate, but, unli[r] ... See full document
6
Herpes simplex virus DNA polymerase as the site of phosphonoacetate sensitivity: temperature-sensitive mutants.
... POWELL* Department of Virology and Epidemiology, Baylor College of Medicine, Houston, Texas 77030 Received for publication 9 June 1977 Temperature-sensitive ts mutants in a surprisingly [r] ... See full document
8
DNA-negative temperature-sensitive mutants of herpes simplex virus type 1: patterns of viral DNA synthesis after temperature shift-up.
... For each gradient, 45 0.1-ml fractions were collected ISCO density gradient fractionator, model 640; Instrumentation Specialties Co., Lincoln, Neb., refractive in- 1043 Downloaded from h[r] ... See full document
6
Biochemical transformation by temperature-sensitive mutants of herpes simplex virus type 1.
... 704 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Biochemical transformation assays of herpes simplex virus type 1 temperaturesensitive ts mutants distinguished three[r] ... See full document
7
Genetic analysis of temperature-sensitive mutants which define the gene for the major herpes simplex virus type 1 DNA-binding protein.
... 354-366 0022-538X/83/010354-13$02.00/0 Copyright C 1983, American Society for Microbiology Genetic Analysis of Temperature-Sensitive Mutants Which Define the Gene for the Major Herpes Si[r] ... See full document
13
Temperature-sensitive mutants of herpes simplex virus type 1 defective in lysis but not in transformation.
... Mutants representing all seven complementation groups failed to grow in either of these two transformed cell lines at the nonpermissive temperature, as measured by plaque formation on th[r] ... See full document
9
Localization of the herpes simplex virus type 1 65-kilodalton DNA-binding protein and DNA polymerase in the presence and absence of viral DNA synthesis.
... 5738-5749 0022-538X/90/125738-12$02.00/0 Copyright C 1990, American Society for Microbiology Localization of the Herpes Simplex Virus Type 1 65-Kilodalton DNA-Binding Protein and DNA Pol[r] ... See full document
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