[PDF] Top 20 Ultrastructural characterization of an early, nonstructural polypeptide of herpes simplex virus type 1.

... In contrast, in cells infected with tsB2 at the nonpermissive temperature, in which VP175 is overproduced 5 and virus DNA synthesis is not detected 1, staining for the protein in a margi[r] ... See full document

... a polypeptide that routinely copurified with AE from HSV-1- infected cell extracts (1, ...the virus-en- coded AE and two of its derivatives in HSV-1-infected cells, thereby confirming ... See full document

... To determine more specifically whether the rates of synthesis of ICPO, ICP27, and ICP6 in d120- and d202-infected cells differ from that in tsB32-infected cells and to examine the possib[r] ... See full document

... 29:275-284, 1979 have shown that the herpes simplex virus type 1 HSV-1 mutant tsK has a temperature-sensitive lesion in an immediate early polypeptide whose function is to induce synthes[r] ... See full document

... Further characterization was achieved by amino acid analysis, determination of the N-terminal amino acid sequence in a gas-phase sequencer and by reaction with monoclonal antibodies dire[r] ... See full document

... lethality early in embryogenesis ...the characterization of skin from Rac1 E-KO mice showed no obvious defects in differentiation, proliferation, cell-cell contacts, and basement membrane deposition in ... See full document

... the ultrastructural, light microscopy, and fraction- ation analyses therefore shows that late in infection the mat- uration and processing of the K⌬UL37 DNA-containing capsids were substantially slowed ... See full document

... of herpes simplex virus type 1 (HSV-1) and plays an essential role in regulating the expression of all three kinetic classes of HSV-1 genes (5–7, 10, 19, ...of ... See full document

... BARKLIE CLEMENTS* Department of Virology and Medical Research Council Virology Unit, University of Glasgow, Church Street, Glasgow Gll 5JR, Scotland The locations on the genome of transc[r] ... See full document

... Isolation and characterisation of a herpes simplex virus type 1 mutant containing a deletion within the gene encoding the immediate early polypeptide VmwllO.. The DNA-binding domains of [r] ... See full document

... We used hybrid-arrested translation to demonstrate that the 155,000-dalton polypeptide encoded by the 6-kb mRNA mapping in HindIII fragment J 0.181 to 0.259 is the only species of that s[r] ... See full document

... 4096-4103 0022-538X/88/114096-08$02.00/0 Copyright C 1988, American Society for Microbiology Characterization of Major Recognition Sequences for a Herpes Simplex Virus Type 1 Origin-Bind[r] ... See full document

... The herpes simplex virus type 1 UL25 protein is incorporated into the capsid during DNA packaging, and previous studies of a null mutant have demonstrated that its function is essential ... See full document

... pes simplex viruses (HSVs) are currently being evaluated in clinical cancer trials for safety and therapeutic activity (32), as well as for vaccine development ...is herpes simplex enceph- alitis ... See full document

... Comparison of polyribosomal distributions of VP16, TK, and ICP8 mRNAs. ICP27 is known to influence the expression of many HSV genes, both positively and negatively, and it was of interest to assess which other viral ... See full document

... to form a functional unit, as proposed by White (37). We found that a proportion of gB, gC, gD, and gH-gL can be found within 11.4 Å of each other. We hypothesize that these close associations may have functional ... See full document

... To obtain the complete nucleotide sequence of the region of the HSV-2 genome encoding gC, the protein encoded by the smaller 3'coterminal message, and the upstream and downstream regulat[r] ... See full document

... blotting and immuno-EM). Fourth, these two capsid types were generated by radically different protocols involving very distinct biophysical properties, i.e., density (sedimentation) or shape and mass (gel filtration). It ... See full document

... Some of the antigens induced by HSV-1 and HSV-2 have been shown to possess cross-reactive determinants which react with antiserum against either HSV-1 or HSV-2, whereas other antigens po[r] ... See full document

... We substituted the dimerization domain of the cellular transcription factor LFB1 for which high-affinity binding to DNA is strictly dependent on dimerization 42 with progressively smalle[r] ... See full document