[PDF] Top 20 Formulation Development and Evaluation of SR Matrix Tablets of Stavudine

... increased. Formulation F1, F2, F3 and F4 were able to sustain the release upto 4,6,12 and 12 h respectively ...case, stavudine is a water soluble drug which allows quicker penetration of dissolution fluid ... See full document

... The stavudine has a very short half- life ...of stavudine are dose dependent and a reduction of the total administered dose reduces the severity of the ...toxicity. Stavudine is typically ... See full document

... the matrix tablets can be analysed by release kinetic ...from matrix system, the release data were fitted into Zero order as cumulative amount of drug release ... See full document

... for Stavudine were prepared by direct compression ...of matrix tablets was found to be ideal and is easy to ...of matrix tablets with incorporation of Sodium bicarbonate as a gas ... See full document

... release formulation of Stavudine is ...a matrix system. Because of their flexibility, hydrophilic polymer matrix systems are widely used in oral controlled drug delivery to obtain a desirable ... See full document

... The response surface methodology is a collection of mathematical and statistical techniques used for modeling and analysis of problems in which a response of interest is influenced by several variable and the objectives ... See full document

... hydrophobic matrix sustained release tablet employing HPMC using different grade materials and the sustained release behavior of the fabricated tablet was ...release matrix tablets containing 60 mg ... See full document

... by their physical parameters and in vitro dissolution profile. The sintering time markedly affected the drug release properties of Compritol® 888 ATO matrices. It is notable that the release rate of ketorolac ... See full document

... compressible matrix tablets by direct compression has attracted much attention due to its technological simplicity in comparison with other controlled release ...Kollidon SR is derived from a ... See full document

... release matrix tablet of Stavudine by using hydrophilic polymer such as HPMC K4M and Methyl ...prepared tablets were ...optimized formulation was found to be F5, which showed 97% drug release ... See full document

... floating matrix formulation of Gliclazide were formulated by using various hydrophilic ...method development was done for the drug ...the formulation was developed by using different ... See full document

... the matrix tablets, the drug release data were fitted to various kinetic models like zero order, first order, higuchi’s and Korsmeyer-peppa’s equation and coefficient of correlation values were calculated ... See full document

... Drug-excipient compatibility studies: Assessment of possible incompatibilities between an active drug substance and different excipients forms an important part of the pre-formulation stage during the ... See full document

... into tablets weighing 200 mg die cavity using the punch size of 10/32 SC’ in a Cadmach double rotary tablet punching machine using appropriate size of standard concave punches to a hardness of 6 to 10 kg/cm 3 ... See full document

... satisfactory tablets. Twenty tablets were randomly selected and each tablet was tested for hardness using Digital Hardness Tester results were as shown in Table ... See full document

... A combination of water-soluble lubricants like sodium benzoate, magnesium stearate, and sod chloride was used in the formulations F6, F7& F8 (Table 1). The disintegration time was good (73 to 76 sec) (Table 1), the ... See full document

... systems. Out of all systems available, the floating beads, floating tablets and floating microspheres have gained major importance. FDDS possess lower bulk density than the gastric fluid exerting buoyancy in the ... See full document

... disintegrating tablets are those that dissolve or disintegrate quickly in the oral cavity, resulting in solution or ...of formulation was tested by Rosette-Rice ... See full document

... floating tablets: Domperidone was mixed with required quantity of polymer (HPMC K4M or carbopol 934P or SA), sodium bicarbonate and lactose in mortar for 5 min by using a ... See full document

... The shorter disintegration time of remaining six formulations was due to the presence of lactose because, Lactose, by its water-soluble and hydrophilic nature, facilitates gel formation and shortens the penetration time ... See full document