[PDF] Top 20 Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.
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Herpes simplex virus origin-binding protein (UL9) loops and distorts the viral replication origin.
... Recombinant Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest To investigate the role of the herpes simplex virus origin-binding protein UL9 in the initiation of DNA repl[r] ... See full document
9
Genome Replication and Progeny Virion Production of Herpes Simplex Virus Type 1 Mutants with Temperature-Sensitive Lesions in the Origin-Binding Protein
... the virus-encoded factors essential for herpes sim- plex virus type 1 (HSV-1) DNA replication (5, 6, 9, 42) is the UL9 gene product (13), which due to its affinity for the origins of HSV-1 DNA ... See full document
6
DNA Binding Activity of the Herpes Simplex Virus Type 1 Origin Binding Protein, UL9, Can Be Modulated by Sequences in the N Terminus: Correlation between Transdominance and DNA Binding
... the protein synthesized from each truncation is indicated at the right side of the ...Prestained protein markers are depicted on the ...infectious viral DNA and the plasmid expressing the indicated ... See full document
10
Helicase Motif Ia Is Involved in Single-Strand DNA-Binding and Helicase Activities of the Herpes Simplex Virus Type 1 Origin-Binding Protein, UL9
... ssDNA- binding function of UL9, whereas the S110T mutation is ...null virus. The titers of viral progeny were determined on the UL9 permissive cell ... See full document
12
Use of transdominant mutants of the origin-binding protein (UL9) of herpes simplex virus type 1 to define functional domains.
... inhibit viral plaque formation ...by binding origin DNA into an inactive ...ATP binding and hydrolysis, since they contain the estab- lished ATP-binding consensus sequences (32, ... See full document
8
The conserved helicase motifs of the herpes simplex virus type 1 origin-binding protein UL9 are important for function.
... Binding of the herpes simplex virus type 1 UL9 gene product to an origin of viral DNA replication.. Nucleic Acids Res.[r] ... See full document
12
Cathepsin B Mediates Cleavage of Herpes Simplex Virus Type 1 Origin Binding Protein (OBP) To Yield OBPC-1, and Cleavage Is Dependent upon Viral DNA Replication
... Construction of the pUL9n24 plasmid. In order to construct a plasmid that would express the UL8.5 transcript and its protein product(s) but not OBP, a DNA fragment containing base pairs 20140 to 24136 of the HSV ... See full document
8
Origin Binding Protein-Containing Protein-DNA Complex Formation at Herpes Simplex Virus Type 1 oriS: Role in oriS-Dependent DNA Replication
... to origin DNA, it has been postulated that OBPC may play a role in HSV DNA replication ...inhibit origin-dependent viral DNA replication and plaque for- mation by infectious HSV-1 DNA, ... See full document
9
Purification and characterization of UL9, the herpes simplex virus type 1 origin-binding protein.
... Two binding sites for the herpes simplex virus type 1 UL9 protein are required for efficient activity of the oriS replication origin.. Genetic analysis of temperature-sensitive mutants w[r] ... See full document
10
Phosphorylation of the Herpes Simplex Virus Type 1 Origin Binding Protein
... The herpes simplex virus type 1 (HSV-1) origin binding protein (OBP), the product of the UL9 gene, is one of seven HSV-encoded proteins required for viral DNA ...DNA ... See full document
10
Herpes Simplex Virus 1 γ134.5 Protein Inhibits STING Activation That Restricts Viral Replication
... pathogenesis in vivo, although its precise function is incompletely characterized (7, 8). Emerging evidence suggests that upon HSV infection, intracellular DNA sensors initiate IFN responses (9). Among them are cyclic ... See full document
11
Properties of the novel herpes simplex virus type 1 origin binding protein, OBPC.
... essential viral DNA replication proteins were cotrans- fected with an oriS-containing test plasmid, pOS822 (54, ...pOS822 replication by 65%, whereas the vector plasmid alone (pCMV) and the plasmid ... See full document
7
Binding sites for the herpes simplex virus immediate-early protein ICP4 impose an increased dependence on viral DNA replication on simple model promoters located in the viral genome.
... The ability of an ICP4 binding site to strongly reduce expression from a simple TATA promoter at early times postinfection is consistent with findings that the ICP4 binding sites in the [r] ... See full document
10
The Neuronal Host Cell Factor-Binding Protein Zhangfei Inhibits Herpes Simplex Virus Replication
... of herpes simplex virus type 1 (HSV-1) immediate- early (IE) genes is initiated by a multiprotein complex comprising the virion-associated protein VP16 and two cellular proteins, host cellular ... See full document
11
Correct intranuclear localization of herpes simplex virus DNA polymerase requires the viral ICP8 DNA-binding protein.
... In the absence of viral DNA replication, HSV Pol colocalized with the HSV DNA-binding protein ICP8 in nuclear framework-associated structures called prereplicative sites.. In the presenc[r] ... See full document
8
Viral replication is required for induction of ocular immunopathology by herpes simplex virus.
... d301 virus (14) contains a deletion in the ICP8 ...major viral DNA-binding protein and is required for viral DNA replication and late gene (g2) ...n504 virus contains a ... See full document
7
Role of protein kinase A and the serine-rich region of herpes simplex virus type 1 ICP4 in viral replication.
... subunits. Binding of cAMP alters the conformation of the regulatory subunits, causing them to dissociate from the ...of protein substrates that contain specific consensus motifs for ...wt virus in ... See full document
11
Adenovirus Type 5 DNA Binding Protein Stimulates Binding of DNA Polymerase to the Replication Origin
... NFI binding. To examine whether DBP is able to stimulate Pol binding, an EMSA was performed with TD50 DNA and increasing amounts of Pol in the presence or absence of DBP ...a protein-DNA complex was ... See full document
8
Formation of a cruciform structure at the simian virus 40 replication origin abolishes T-antigen binding to the origin in vitro.
... 293-297 0022-538X/85/100293-05$02.00/0 Copyright © 1985, American Society for Microbiology NOTES Formation of a Cruciform Structure at the Simian Virus 40 Replication Origin Abolishes T-[r] ... See full document
5
The T-antigen-binding domain of the simian virus 40 core origin of replication.
... The lesser role of these intervening sequences is probably related to T-antigen binding rather than to cruciform formation because the central base pair at position 5243 would have no ef[r] ... See full document
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