[PDF] Top 20 Quantitative Trait Loci Analysis Using the False Discovery Rate
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Quantitative Trait Loci Analysis Using the False Discovery Rate
... one false linkage per genome scan on the average. Using the Poisson approximation, such a threshold is equivalent to controlling the FWE at .... using an FWER controlling method, one may claim that ... See full document
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Controlling for false positive findings of trans hubs in expression quantitative trait loci mapping
... linkage analysis for GAW15 data using robust score statistics, which enjoy excellent compu- tational efficiency (20 seconds for computing the score statistics for 3554 expressions on 1197 markers in R on a ... See full document
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Survival Analysis of Life Span Quantitative Trait Loci in Drosophila melanogaster
... We used quantitative trait loci (QTL) mapping to evaluate the age specificity of naturally segregating alleles affecting life span. Estimates of age-specific mortality rates were obtained from ... See full document
14
Multiple trait analysis of genetic mapping for quantitative trait loci.
... We examined, in detail, various advantages and disadvantages of the joint analysis as compared to sepa- rate analyses for mapping QTL and also for testing a number of hyp[r] ... See full document
17
Genomic interrogation of familial short stature contributes to the discovery of the pathophysiological mechanisms and pharmaceutical drug repositioning
... Expression quantitative trait locus; FDR: False discovery rate; FR: Fruchterman-Reingold; FSS: Familial short stature; GAD: Gene-Disease Associations; GO: Gene ontology; GSEA: Gene set ... See full document
12
A Whole Genome Scan for Quantitative Trait Loci Affecting Milk Protein Percentage in Israeli-Holstein Cattle, by Means of Selective Milk DNA Pooling in a Daughter Design, Using an Adjusted False Discovery Rate Criterion
... error rate (CWER), or Microsatellites: A total of 138 dinucleotide microsatellite type I error P-value, was calculated for each test using standard markers distributed over all 29 bovine autosomes were used ... See full document
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Multiple Quantitative Trait Loci Mapping With Cofactors and Application of Alternative Variants of the False Discovery Rate in an Enlarged Granddaughter Design
... as defined above for sire j in the grandsire family i at chromo- and the QTL transition probability, and the remaining vari- somal position k. The null hypothesis was that no QTL segre- ables are as defined above. Note ... See full document
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Identification of expression quantitative trait loci by the interaction analysis using genetic algorithm
... algorithm. Using this set of major and minor SNPs, we applied the GA for interaction ...mutation rate of 0.4, a minor mutation rate of 0.1, a cross-over rate of ... See full document
5
Identification of recombination hotspots and quantitative trait loci for recombination rate in layer chickens
... a quantitative trait to map genetic variants that influence recombination ...for analysis [9, 37, ...recombination rate were identified in ... See full document
13
Association of human XPA rs1800975 polymorphism and cancer susceptibility: an integrative analysis of 71 case–control studies
... FPRP: False-positive report probability; TSA: Trial sequential analysis; eQTL: Expression quantitative trait loci; sQTL: Splicing quantitative trait loci; BCC: ... See full document
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Application of the False Discovery Rate to Quantitative Trait Loci Interval Mapping With Multiple Traits
... definition false for traits the multiple-trait test, the number of QTL detected for that have been shown by prior biometrical analyses to carcass weight and last rib back fat at the 10% level have nonzero ... See full document
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Integrative analysis of vascular endothelial cell genomic features identifies AIDA as a coronary artery disease candidate gene
... cells using Lipofectamine 2000 (ThermoFisher, 11,668,027) for 4 h then switched to virus-producing media contain- ing 10 μg/mL of ...PCR using primers sur- rounding the expected deletion (out-out PCR) (Add- ... See full document
13
A Statistical Framework for Quantitative Trait Mapping
... data analysis consists of a model scanning step Prior distributions: All Bayesian analyses depend on followed by model ...reference false positive results (Lander and Kruglyak ... See full document
17
The Association of Flowering Time Quantitative Trait Loci with Duplicated Regions and Candidate Loci in Brassica oleracea
... trials. Using information on 82 mapped molecular markers, spread evenly across the nine linkage groups, QTL were identified at six locations; one each on linkage groups O2 and O3 and two each on linkage groups O5 ... See full document
9
Multitrait Fine Mapping of Quantitative Trait Loci Using Combined Linkage Disequilibria and Linkage Analysis
... marker loci or QTL is ...linkage analysis, rounding the gene, linkage disequilibrium between that the statistical power to detect a QTL can be in- haplotypes and QTL loci can be utilized to map QTL ... See full document
6
Multiple Interval Mapping for Quantitative Trait Loci
... rows in Q according to its flanking marker genotype. groups to cover most of the genome. A QTL is poten- Given the matrices D and Q, the MLEs and the asymp- tially located in any position of each interval. To detect ... See full document
14
Fast genome wide pedigree quantitative trait loci analysis using MENDEL
... an ultra-fast score test when pedigree structure is explicitly given. Score tests require no additional iteration under the alternative model.All that is needed is evaluation of a quadratic form combining the score ... See full document
5
Bayesian Methods for Quantitative Trait Loci Mapping Based on Model Selection: Approximate Analysis Using the Bayesian Information Criterion
... maximum likelihood. In a single model, estimates and Our approach is to relate trait values directly to confidence intervals from maximum likelihood will be marker genotypes, using multiple linear ... See full document
14
Precision mapping of quantitative trait loci.
... There will be, however, some interference on testing and estimation between those QTLs which are located in adjacent marker intervals when using this composite interval mapping met[r] ... See full document
12
Modeling Epistasis of Quantitative Trait Loci Using Cockerham's Model
... Again, the partial regression coefficients of the additive by the genetic parameters of dominance effect of and dominance effects are confounded by epistatic ef- locus B (d 2 ). Both the F ∞ -metric and mixed-metric ... See full document
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