[PDF] Top 20 Host range temperature-sensitive mutants of herpes simplex virus type 2.
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Host range temperature-sensitive mutants of herpes simplex virus type 2.
... The temperature92 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Two small-plaque mutants of herpes simplex virus type 2 HSV-2 strain 333, whose growth at 39 C was blo[r] ... See full document
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Paired Charge-to-Alanine Mutagenesis of Dengue Virus Type 4 NS5 Generates Mutants with Temperature-Sensitive, Host Range, and Mouse Attenuation Phenotypes
... Dengue virus (DEN) (genus Flavivirus, family Flaviviridae) is a single-stranded, positive-sense RNA virus with a ...geographic range of all four serotypes and the cocirculation of two or more ... See full document
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Genome Replication and Progeny Virion Production of Herpes Simplex Virus Type 1 Mutants with Temperature-Sensitive Lesions in the Origin-Binding Protein
... sive temperature) must have arisen by some kind of origin- independent ...wild-type virus after coinfection with ts ...wild type at an MOI of ...wt virus at an MOI of ...wt virus ... See full document
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Genetic analysis of temperature-sensitive mutants which define the genes for the major herpes simplex virus type 2 DNA-binding protein and a new late function.
... 343-353 0022-538X/83/010343-11$02.00/0 Copyright C 1983, American Society for Microbiology Genetic Analysis of Temperature-Sensitive Mutants Which Define the Genes for the Major Herpes S[r] ... See full document
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Alkaline DNase activity in cells infected with a temperature-sensitive mutant of herpes simplex virus type 2.
... To test whether the appearance of alkaline nuclease in ts13-infected cells after a shift to a permissive temperature was due to de novo synthesis or to the activation of an inactive enzy[r] ... See full document
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Characterization of herpes simplex virus 2 temperature-sensitive mutants whose lesions map in or near the coding sequences for the major DNA-binding protein.
... In cells infected with certain of these mutants at the nonpermissive temperature, the association of the major DNA-binding protein with the cell nucleus was defective.. In these cells, t[r] ... See full document
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Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175.
... Consistent with this model are the following observations: i certain late proteins e.g., VP154 can be expressed in the absence of functional VP175 this study, ii VP175 is required for ce[r] ... See full document
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Temperature-sensitive host range mutants of herpes simplex virus type 2.
... In this report we describe the isolation and preliminary characterization of four mutants of HSV-2 strain 333 which are temperature sensitive in hamster embryo fibroblast HEF cells but s[r] ... See full document
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Herpes Simplex Virus ICP0 Mutants Are Hypersensitive to Interferon
... cells. Herpes simplex virus type 1 (HSV-1) replication is somewhat reduced in tissue culture in the presence of IFN, presumably due to decreased viral ...exquisitely sensitive to IFN ... See full document
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DNA-negative temperature-sensitive mutants of herpes simplex virus type 1: patterns of viral DNA synthesis after temperature shift-up.
... For each gradient, 45 0.1-ml fractions were collected ISCO density gradient fractionator, model 640; Instrumentation Specialties Co., Lincoln, Neb., refractive in- 1043 Downloaded from h[r] ... See full document
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Genetic analysis of temperature-sensitive mutants which define the gene for the major herpes simplex virus type 1 DNA-binding protein.
... 354-366 0022-538X/83/010354-13$02.00/0 Copyright C 1983, American Society for Microbiology Genetic Analysis of Temperature-Sensitive Mutants Which Define the Gene for the Major Herpes Si[r] ... See full document
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Cysteine mutants of herpes simplex virus type 1 glycoprotein D exhibit temperature-sensitive properties in structure and function.
... When we analyzed each of the mutants in a complementation assay for virus function 38, only two mutant proteins, Cys-2 and Cys-4, Glycoprotein D gD of herpes simplex virus HSV is a struc[r] ... See full document
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Pathogenesis of Herpes Simplex Virus Type 2 Virion Host Shutoff (vhs) Mutants
... null mutants, however, have a greatly reduced (up to 10,000-fold) ability to replicate in the nervous system and to establish and reactivate from latency compared to wild-type virus (30, ...more ... See full document
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Electron microscope studies of temperature-sensitive mutants of herpes simplex virus type 2.
... For infectivity assay a 1.5-ml sample of infected cell suspension was frozen, thawed, and then sonicated for 1 min at 10 kcycles/s with a 727 Downloaded from http://jvi.asm.org/ on Novem[r] ... See full document
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Biochemical transformation by temperature-sensitive mutants of herpes simplex virus type 1.
... 704 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Biochemical transformation assays of herpes simplex virus type 1 temperaturesensitive ts mutants distinguished three[r] ... See full document
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Temperature-sensitive mutants of herpes simplex virus type 1 defective in lysis but not in transformation.
... Mutants representing all seven complementation groups failed to grow in either of these two transformed cell lines at the nonpermissive temperature, as measured by plaque formation on th[r] ... See full document
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Inhibition of herpes simplex virus type 1 replication in temperature-sensitive cell cycle mutants.
... In addition, survival rates determined from plating efficiencies of the various cell mutants after incubations at 39.5°C for the time periods corresponding 42 Downloaded from http://jvi.[r] ... See full document
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Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2.
... TIMBURY't Division of Basic Sciences, Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, and Department of Virology, Baylor College ofMedicine, Houston,[r] ... See full document
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Temperature-sensitive mutants in herpes simplex virus type 1 ICP4 permissive for early gene expression.
... Fifteen to fifty percent of wild-type levels of viral DNA are synthesized at the nonpermissive temperature in ts48- and ts303-infected cells, indicating that immediate-early and early ge[r] ... See full document
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Viral DNA synthesis in cells infected with temperature-sensitive mutants of herpes simplex virus type 1.
... and 10% vol/vol tryptose phosphate broth Difco on 314 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Temperature-sensitive mutants of herpes simplex virus type 1 repre[r] ... See full document
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