[PDF] Top 20 Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2.
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Collaborative complementation study of temperature-sensitive mutants of herpes simplex virus types 1 and 2.
... TIMBURY't Division of Basic Sciences, Sidney Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, and Department of Virology, Baylor College ofMedicine, Houston,[r] ... See full document
15
Control of expression of the herpes simplex virus-induced deoxypyrimidine triphosphatase in cells infected with mutants of herpes simplex virus types 1 and 2 and intertypic recombinants.
... Of a series of temperature-sensitive mutants of HSV-2 strain HG52, ts9 and tsl3 failed to induce wild-type levels of the enzyme at nonpermissive temperature; ts9 was the most defective m[r] ... See full document
8
DNA synthesis and DNA polymerase activity of herpes simplex virus type 1 temperature-sensitive mutants.
... The remaining mutants studied, all of which were DNA- at 39 C Table 1, fell into three categories with respect to their ability to induce DP activity at 39 C Table 2: i mutants belonging[r] ... See full document
10
Disulfide bond structure of glycoprotein D of herpes simplex virus types 1 and 2.
... Cysteine mutants of herpes simplex virus type 1 glycoprotein D exhibit temperature-sensitive properties in structure and function.. Glycoprotein D protects mice against lethal challenge [r] ... See full document
18
Herpes Simplex Virus Types 1 and 2 Differ in Their Interaction with Heparan Sulfate
... this study, we observed that HSV-1 and HSV-2 virions dif- fered with respect to the quantity of HS chains ...less sensitive than HSV-2 to O-desulfated heparin preparations, suggesting ... See full document
9
Genome Replication and Progeny Virion Production of Herpes Simplex Virus Type 1 Mutants with Temperature-Sensitive Lesions in the Origin-Binding Protein
... with herpes simplex virus type ...of temperature sensitive mutants, their arrangement into complementation groups and recombina- tion analysis leading to a linkage ... See full document
6
Cysteine mutants of herpes simplex virus type 1 glycoprotein D exhibit temperature-sensitive properties in structure and function.
... When we analyzed each of the mutants in a complementation assay for virus function 38, only two mutant proteins, Cys-2 and Cys-4, Glycoprotein D gD of herpes simplex virus HSV is a struc[r] ... See full document
11
Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175.
... Consistent with this model are the following observations: i certain late proteins e.g., VP154 can be expressed in the absence of functional VP175 this study, ii VP175 is required for ce[r] ... See full document
15
Electron microscope studies of temperature-sensitive mutants of herpes simplex virus type 2.
... For infectivity assay a 1.5-ml sample of infected cell suspension was frozen, thawed, and then sonicated for 1 min at 10 kcycles/s with a 727 Downloaded from http://jvi.asm.org/ on Novem[r] ... See full document
11
Temperature-sensitive mutants of herpes simplex virus type 1 defective in lysis but not in transformation.
... Mutants representing all seven complementation groups failed to grow in either of these two transformed cell lines at the nonpermissive temperature, as measured by plaque formation on th[r] ... See full document
9
Viral DNA synthesis in cells infected with temperature-sensitive mutants of herpes simplex virus type 1.
... and 10% vol/vol tryptose phosphate broth Difco on 314 Downloaded from http://jvi.asm.org/ on November 10, 2019 by guest Temperature-sensitive mutants of herpes simplex virus type 1 repre[r] ... See full document
6
Characterization of a temperature-sensitive mutant of the UL15 open reading frame of herpes simplex virus 1.
... In this series of experiments, replicate 25-cm2 cultures of Vero cells were infected in duplicate with the parent, mutant, or rescued virus 5 PFU per cell and incubated in a 34°C incubat[r] ... See full document
7
Temperature-sensitive host range mutants of herpes simplex virus type 2.
... In this report we describe the isolation and preliminary characterization of four mutants of HSV-2 strain 333 which are temperature sensitive in hamster embryo fibroblast HEF cells but s[r] ... See full document
8
Structural analysis of the capsid polypeptides of herpes simplex virus types 1 and 2.
... Comparative peptide analysis of HSV1 and HSV-2 showed that one polypeptide NC-7, 12,000 molecular weight had an identical methionine peptide profile and a very similar arginine peptide p[r] ... See full document
11
Comparison of the virion proteins specified by herpes simplex virus types 1 and 2.
... A recent study of the structural polypeptides specified by 53 different HSV-1 strains revealed that certain polypeptide bands with characteristic electrophoretic mobilities in SDS gels w[r] ... See full document
5
Temperature-sensitive mutants of Chandipura virus. II. Phenotypic characteristics of the six complementation groups.
... Weak complementation was observed between certain mutants in group ChI, and it was possible to distinguish two subgroups ChIA and ChIB by their interaction with mutant ts Chl, an arbitra[r] ... See full document
8
INTRAGENIC COMPLEMENTATION AMONG TEMPERATURE SENSITIVE MUTANTS OF BACTERIOPHAGE T4D
... for example) which in some cases (the head protein for example) may be required in large amounts for phage assembly. Still other gene products may be required in amounts much lower th[r] ... See full document
16
Mapping of RNA- temperature-sensitive mutants of Sindbis virus: complementation group F mutants have lesions in nsP4.
... Thus, we conclude that tsll8 is a double mutant in which a mutation in the B region results in formation of minute plaques at 40°C but no change in plaque number and a second mutation in[r] ... See full document
9
Nongenetic complementation of group V temperature-sensitive mutants of vesicular stomatitis virus by UV-irradiated virus.
... 798-805 Copyright © 1975 American Society for Microbiology Nongenetic Complementation of Group V Temperature-Sensitive Mutants of Vesicular Stomatitis Virus by UV-Irradiated Virus VICTOR[r] ... See full document
8
Characterization of herpes simplex virus 2 temperature-sensitive mutants whose lesions map in or near the coding sequences for the major DNA-binding protein.
... In cells infected with certain of these mutants at the nonpermissive temperature, the association of the major DNA-binding protein with the cell nucleus was defective.. In these cells, t[r] ... See full document
11
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