Stabilizing selection
Stabilizing Selection, Purifying Selection, and Mutational Bias in Finite Populations
... to stabilizing selection rather than purifying ...of stabilizing selection on genomic traits, the effects of mutational bias on the equilibrium value of a trait under stabilizing ...
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Joint Effects of Pleiotropic Selection and Stabilizing Selection on the Maintenance of Quantitative Genetic Variation at Mutation-Selection Balance
... real stabilizing selection, selection is assumed to arise solely from the deviations of the metric traits from their optimum due to mutational effects ...phenotypic selection, selection ...
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On models of quantitative genetic variability: a stabilizing selection-balance model.
... T h e nature of the stable polymorphic states that we are able to study, under stabilizing selection, suggests that MATHER’S polygenic balance is not a tenable hypothesis[r] ...
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The Effects of Intraspecific Competition and Stabilizing Selection on a Polygenic Trait
... pure stabilizing selection and what role comes almost exclusively from variation in the ecologi- the other parameters in the model, such as number of cal ...
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Genetic Variation Maintained in Multilocus Models of Additive Quantitative Traits Under Stabilizing Selection
... Stabilizing selection for an intermediate optimum is generally considered to deplete genetic variation in quantitative ...under stabilizing selection, several analyses of two-locus models ...
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ADDITIVE VARIATION MAINTAINED UNDER STABILIZING SELECTION: A TWO-LOCUS MODEL OF PLEIOTROPY FOR TWO QUANTITATIVE CHARACTERS
... Thus, the model presented in this paper demonstrates that two additive quantitative characters, each being under direct stabilizing selection, can main- tain a high level[r] ...
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Adaptive Fixation in Two-Locus Models of Stabilizing Selection and Genetic Drift
... of stabilizing selection? In contrast to quantitative genetics, in population genetics and genomics our under- standing of the genetics of adaptation has revolved in recent years around the role of ...
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The Genetics of Adaptation: The Roles of Pleiotropy, Stabilizing Selection and Drift in Shaping the Distribution of Bidirectional Fixed Mutational Effects
... of selection and opposite to selection for the same ...directional selection is occurring, and, not surprisingly, as the degree of pleiotropy increases the frequency of fixed deleterious effects ...
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Dynamics of genetic variability in two-locus models of stabilizing selection.
... We demonstrate that under these conditions, which are plausible in nature and certainly the case in artificial stabilizing selection experi- ments, the model can have a polymorphic[r] ...
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Mutational Pleiotropy and the Strength of Stabilizing Selection Within and Between Functional Modules of Gene Expression
... A genotype–phenotype map in which pleiotropic effects are relatively restricted to groups of functionally integrated traits has been predicted to be evolutionarily beneficial (Wagner 1996). Here, we provide a test of ...
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Stability and Response of Polygenic Traits to Stabilizing Selection and Mutation
... to selection immensely intricate, even under the simplest assumptions ...of stabilizing selection, either by the direct action of selection on a trait whose extreme values are unfit or ...
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Pleiotropic Mutations Are Subject to Strong Stabilizing Selection
... strong selection acting against new mutations affecting the adult male ...stronger selection than expected under neutral evolution, and 17% had selection coefficients ...of selection commonly ...
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Pleiotropic models of polygenic variation, stabilizing selection, and epistasis.
... Stabilizing selection is also observed if the polygenic system is at an equilibrium determined by a balance between selection and mutation (or migration) when both additive an[r] ...
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THE EFFECTS OF DISRUPTIVE AND STABILIZING SELECTION ON BODY SIZE IN DROSOPHILA MELANOGASTER. I. MEAN VALUES AND VARIANCES
... Sta- bilizing selection (S) on thorax length or wing length did not decrease the phenotypic variance, but the mean value of the selected character declined.- The proport[r] ...
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Genotypic variation for a quantitative character maintained under stabilizing selection without mutations: epistasis.
... Results in Table 1 clearly demonstrate that large amounts of genotypic variation (close to the maximum possible without selection) can be maintained for a quantitative [r] ...
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Maintenance of genetic variability under strong stabilizing selection: a two-locus model.
... We show that if the double heterozygote has the optimum phenotype and the contributions of the loci to the trait are different, then any symmetric stabilizing se[r] ...
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THE EFFECT OF DISRUPTIVE AND STABILIZING SELECTION ON THE EXPRESSION OF A CUBITUS INTERRUPTUS MUTANT IN DROSOPHILA
... Although the disruptive line shows a tendency to lower values than the stabilizing line, there is no systematic change, and the difference is, of course, negligible[r] ...
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THE EFFECTS OF DISRUPTIVE AND STABILIZING SELECTION ON BODY SIZE IN DROSOPHILA MELANOGASTER. II. ANALYSIS OF RESPONSES IN THE THORAX SELECTION LINES
... of the phenotypic variance and the large increase of the mean value in the disruptive selection lines with random mating ( D E ) could be attributed to differences[r] ...
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Pleiotropic stabilizing selection limits the number of polymorphic loci to at most the number of characters.
... We also assume linkage equilibrium, and that either the number of loci is large enough that the phenotypic distribution in the population can be approximated as [r] ...
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Substitution Rates Under Stabilizing Selection
... For the values of 8 chosen here, the substitution times at both loci for neutral alleles are almost exactly 3/2 the substitution time at a single locus, as would be t[r] ...
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